CoQ10 have high molecular weight and poor water solubility. And the oral bioavailability of CoQ10 is very low. Our objective of this study was to improve the oral bioavailability of CoQ10 by microemulsion formulations and to investigate it's characteristics. The solubility of CoQ10 in oil and surfac...
CoQ10 have high molecular weight and poor water solubility. And the oral bioavailability of CoQ10 is very low. Our objective of this study was to improve the oral bioavailability of CoQ10 by microemulsion formulations and to investigate it's characteristics. The solubility of CoQ10 in oil and surfactant were evaluated to identify the components of the microemulsion. The ternary phase diagram were developed for various microemulsion formulations composed of oleic acid, Cremorphor EL and propylene glycol. CoQ10 microemulsions characteristics were evaluated in terms of particle size and stability(light, temperature, pH). Pharmacokinetic study were done after oral administration of each formulation to Sprague-Dawey rats, and the analysis of CoQ10 was performed by HPLC. The results showed that the microemulsion formulationⅠ composed of oleic acid(3.8% w/w), Cremorphor EL(19.2% w/w), propylene glycol(19.2% w/w), water(57.4% w/w). And microemulsion formulationⅠwas stable in condition of pH 2.6, pH 8.0 and 4℃, 20℃, 40℃. Light, affected the CoQ10 stability significantly Stability of CoQ10 at formulation Ⅰ, Ⅱ were significantly decresed in condition light unprotect. CoQ10 microemulsion formulation composed of oleic acid(3.8% w/w), Cremorphor EL(19.2% w/w), propylene glycol(19.2% w/w), water(57.4% w/w) was stable in condition of pH 2.6, pH 8.0 and 4℃, 20℃, 40℃, but the light(20,000Lux) affected significantly the CoQ10 microemulsion stability. And microemulsion formulation Ⅰ, Ⅱ of CoQ10 improved oral bioavailability three times better than control.
CoQ10 have high molecular weight and poor water solubility. And the oral bioavailability of CoQ10 is very low. Our objective of this study was to improve the oral bioavailability of CoQ10 by microemulsion formulations and to investigate it's characteristics. The solubility of CoQ10 in oil and surfactant were evaluated to identify the components of the microemulsion. The ternary phase diagram were developed for various microemulsion formulations composed of oleic acid, Cremorphor EL and propylene glycol. CoQ10 microemulsions characteristics were evaluated in terms of particle size and stability(light, temperature, pH). Pharmacokinetic study were done after oral administration of each formulation to Sprague-Dawey rats, and the analysis of CoQ10 was performed by HPLC. The results showed that the microemulsion formulationⅠ composed of oleic acid(3.8% w/w), Cremorphor EL(19.2% w/w), propylene glycol(19.2% w/w), water(57.4% w/w). And microemulsion formulationⅠwas stable in condition of pH 2.6, pH 8.0 and 4℃, 20℃, 40℃. Light, affected the CoQ10 stability significantly Stability of CoQ10 at formulation Ⅰ, Ⅱ were significantly decresed in condition light unprotect. CoQ10 microemulsion formulation composed of oleic acid(3.8% w/w), Cremorphor EL(19.2% w/w), propylene glycol(19.2% w/w), water(57.4% w/w) was stable in condition of pH 2.6, pH 8.0 and 4℃, 20℃, 40℃, but the light(20,000Lux) affected significantly the CoQ10 microemulsion stability. And microemulsion formulation Ⅰ, Ⅱ of CoQ10 improved oral bioavailability three times better than control.
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