[학위논문]건강한 성인에서 폐기능 감소와 인슐린 저항성의 관련성: 단면조사연구 Decreased pulmonary function associated with insulin resistance in health adults : a cross-sectional study원문보기
Aim: Metabolic syndrome is generally considered as a pro-thrombotic and pro-inflammatory state. Recently, it have been reported that lung function impairment is associated with metabolic, cardiovascular diseases and other extra pulmonary diseases. But, the mechanism between lung function and metabol...
Aim: Metabolic syndrome is generally considered as a pro-thrombotic and pro-inflammatory state. Recently, it have been reported that lung function impairment is associated with metabolic, cardiovascular diseases and other extra pulmonary diseases. But, the mechanism between lung function and metabolic syndromes is not clear. So, we had investigated the association between pulmonary function and risk factors for metabolic syndrome, especially insulin resistance.
Methods: A cross-sectional study was carried out in a Korean population of 340 adults. But we excluded 54 subjects who had insufficient blood samples, history of chronic obstructive disease, asthma and cardiovascular disease. Finally total 286 subjects were available for analysis (mean age of 60.2 years). As an index of lung function, we had measured spirometry and estimated the prediction percent of forced vital capacity (FVC) and forced expiratory at 1 second (FEV1). The fasting glucose and insulin levels of all subjects were measured and homeostasis model assessment index for insulin resistance (HOMA-IR) were calculated.
Results: The smoking pack year was inversely correlated with FVC (r=-0.230, p=0.001) and FEV1 (r=-0.231, p=0.003), but not correlated with insulin resistance in ex-smoker and current smoker. However the HOMA-IR was inversely correlated with FVC (r=-6.236, p=0.001) and FEV1 (r=-7.251, p=0.005) in non-smoking subjects. Furthermore, a stepwise multivariate regression analysis revealed that HOMA-IR was only associated with pulmonary function in non-smokers.
Conclusion: We conclude that insulin resistance is associated with pulmonary function in non-smoking healthy populations. Contrarily, increased insulin resistance is associated with decreased pulmonary function, independently of age, gender, height and weight and other possible confounding variables. So, we have suggested that the insulin resistance could be the one cause of decreased pulmonary function in extra pulmonary diseases.
Aim: Metabolic syndrome is generally considered as a pro-thrombotic and pro-inflammatory state. Recently, it have been reported that lung function impairment is associated with metabolic, cardiovascular diseases and other extra pulmonary diseases. But, the mechanism between lung function and metabolic syndromes is not clear. So, we had investigated the association between pulmonary function and risk factors for metabolic syndrome, especially insulin resistance.
Methods: A cross-sectional study was carried out in a Korean population of 340 adults. But we excluded 54 subjects who had insufficient blood samples, history of chronic obstructive disease, asthma and cardiovascular disease. Finally total 286 subjects were available for analysis (mean age of 60.2 years). As an index of lung function, we had measured spirometry and estimated the prediction percent of forced vital capacity (FVC) and forced expiratory at 1 second (FEV1). The fasting glucose and insulin levels of all subjects were measured and homeostasis model assessment index for insulin resistance (HOMA-IR) were calculated.
Results: The smoking pack year was inversely correlated with FVC (r=-0.230, p=0.001) and FEV1 (r=-0.231, p=0.003), but not correlated with insulin resistance in ex-smoker and current smoker. However the HOMA-IR was inversely correlated with FVC (r=-6.236, p=0.001) and FEV1 (r=-7.251, p=0.005) in non-smoking subjects. Furthermore, a stepwise multivariate regression analysis revealed that HOMA-IR was only associated with pulmonary function in non-smokers.
Conclusion: We conclude that insulin resistance is associated with pulmonary function in non-smoking healthy populations. Contrarily, increased insulin resistance is associated with decreased pulmonary function, independently of age, gender, height and weight and other possible confounding variables. So, we have suggested that the insulin resistance could be the one cause of decreased pulmonary function in extra pulmonary diseases.
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