SLN(Solid LipidNanoparticles)에 활성성분을 봉입하여 화장품 분야의 피부 전달체로서 응용하기 위한 기초자료를 제공하였다. 제조한 지질과 계면활성제의 종류 그리고 지질과 계면활성제의 혼합비(2/1, 1/1, 1/2)가 SLN의 입자크기, 안정성, 결정모양, 결정성 및 결정화도와 봉입된 ...
SLN(Solid LipidNanoparticles)에 활성성분을 봉입하여 화장품 분야의 피부 전달체로서 응용하기 위한 기초자료를 제공하였다. 제조한 지질과 계면활성제의 종류 그리고 지질과 계면활성제의 혼합비(2/1, 1/1, 1/2)가 SLN의 입자크기, 안정성, 결정모양, 결정성 및 결정화도와 봉입된 활성물질의 봉입률 및 방출량에 미치는 영향을 연구하였다. 지질은 고급지방산(C12~C18 : lauric acid, myristic acid, palmitic acid, and stearic acid)과 고급알코올(C12~C18 : lauryl alcohol, myristyl alcohol, cetyl alcohol and stearyl alcohol) 그리고 탄화수소 오일(C12~C18 : dodecane, tetradecane, hexadecae and octadecane)을 사용하였다. 계면활성제는 Tween20, Tween40, Tween60 and Tween80을 사용하였고 지질과 계면활성제 혼합비는 2/1, 1/1, 1/2로 하였다. 활성성분으로는 비타민 A, C 및 E를 사용하였다. SLN의 입자크기는 지질의 탄화수소 길이가 증가할수록(C12, C14, C16, C18), 계면활성제의 소수기 길이가 증가할수록(C14, C16, C18, C18-1) 그리고 지질과 계면활성제의 혼합비가 2/1, 1/1, 1/2 순으로 감소하였다. SLN의 제타전위 값은 지질의 탄화수소 길이와 계면활성제의 종류 및 혼합비에 관계없이 고급지방산으로 제조한 경우 -30.0mV~-50.0mV, 고급알코올로 제조한 경우 -20.0mV~-40.0mV 그리고 탄화수소 오일로 제조한 경우 -10.0mV~-30.0mV로 나타났다. Stearic acid와 stearyl alcohol, TW80으로 제조한 SLN에 대하여 비타민 A, C 및 E를 봉입한 결과 봉입한 SLN의 입자크기는 봉입하지 않은 SLN보다 22.3% 크게 나타났다. 결정성은 stearic acid의 SLN이 stearyl alcohol의 SLN보다 높았으며 비타민 A, C, E 순으로 감소하였다. 비타민 A, C 및 E에 대한 stearic acid의 SLN이 봉입률은 88.4%, 70.8%, 93.5%, 방출량은 23.9%, 32.3% 및 48.1%이었으며, stearyl alcohol의 SLN 봉입률은 69.4, 44.5%, 92.4%, 방출량은 53.9%, 60.9% 및 88.9%이었다.
SLN(Solid Lipid Nanoparticles)에 활성성분을 봉입하여 화장품 분야의 피부 전달체로서 응용하기 위한 기초자료를 제공하였다. 제조한 지질과 계면활성제의 종류 그리고 지질과 계면활성제의 혼합비(2/1, 1/1, 1/2)가 SLN의 입자크기, 안정성, 결정모양, 결정성 및 결정화도와 봉입된 활성물질의 봉입률 및 방출량에 미치는 영향을 연구하였다. 지질은 고급지방산(C12~C18 : lauric acid, myristic acid, palmitic acid, and stearic acid)과 고급알코올(C12~C18 : lauryl alcohol, myristyl alcohol, cetyl alcohol and stearyl alcohol) 그리고 탄화수소 오일(C12~C18 : dodecane, tetradecane, hexadecae and octadecane)을 사용하였다. 계면활성제는 Tween20, Tween40, Tween60 and Tween80을 사용하였고 지질과 계면활성제 혼합비는 2/1, 1/1, 1/2로 하였다. 활성성분으로는 비타민 A, C 및 E를 사용하였다. SLN의 입자크기는 지질의 탄화수소 길이가 증가할수록(C12, C14, C16, C18), 계면활성제의 소수기 길이가 증가할수록(C14, C16, C18, C18-1) 그리고 지질과 계면활성제의 혼합비가 2/1, 1/1, 1/2 순으로 감소하였다. SLN의 제타전위 값은 지질의 탄화수소 길이와 계면활성제의 종류 및 혼합비에 관계없이 고급지방산으로 제조한 경우 -30.0mV~-50.0mV, 고급알코올로 제조한 경우 -20.0mV~-40.0mV 그리고 탄화수소 오일로 제조한 경우 -10.0mV~-30.0mV로 나타났다. Stearic acid와 stearyl alcohol, TW80으로 제조한 SLN에 대하여 비타민 A, C 및 E를 봉입한 결과 봉입한 SLN의 입자크기는 봉입하지 않은 SLN보다 22.3% 크게 나타났다. 결정성은 stearic acid의 SLN이 stearyl alcohol의 SLN보다 높았으며 비타민 A, C, E 순으로 감소하였다. 비타민 A, C 및 E에 대한 stearic acid의 SLN이 봉입률은 88.4%, 70.8%, 93.5%, 방출량은 23.9%, 32.3% 및 48.1%이었으며, stearyl alcohol의 SLN 봉입률은 69.4, 44.5%, 92.4%, 방출량은 53.9%, 60.9% 및 88.9%이었다.
The purpose of this study is to apply SLNs (solid lipid nanoparticles) loaded with active ingredients as epidermal carriers to the cosmetics. The particle size, stability, crystalline shape, crystallinity, encapsulation efficiency, and releasing amount of the prepared SLN were investigated according...
The purpose of this study is to apply SLNs (solid lipid nanoparticles) loaded with active ingredients as epidermal carriers to the cosmetics. The particle size, stability, crystalline shape, crystallinity, encapsulation efficiency, and releasing amount of the prepared SLN were investigated according to the various type of lipids, surfactants, its mixing ratio, and active ingredients. The components of SLN were as follows ; the fatty acid were lauric acid, myristic acid, palmitic acid, and stearic acid, the long chain alcohols were lauryl alcohol, myristyl alcohol, cetyl alcohol, and stearyl alcohol, the hydrocarbon oils were dodecane, tetradecane, hexadecae and octadecane, the nonionic surfactants were TW20, TW40, TW60, and TW80. And the active ingredients were vitamin A, C, and E. The particle size of the SLN decreased according to the increase of the alkyl chain length of the lipids(C12, C14, C16, C18), the hydrophobic chain length of the surfactants (C14, C16, C18, C18-1), and in the sequence of 2/1, 1/1, 1/2 for mixing ratio of lipid and surfactant. Regardless of the chain length of the lipids, the surfactants, and its mixing ratio, the zeta potential values of the SLN for the fatty acids, the long chain alcohols, and the hydrocarbon oils were -30.0mV∼-50.0mV, -20.0mV∼ -40.0mV and -10.0mV∼-30.0mV, respectively. The particle size of the SLN, which was prepared with stearic acid, stearyl alcohol, and TW80, loaded with the active ingredients (vitamin A, C, and E) increased by 22.3% more than that of the unloaded SLN. The crystalliity of the stearic acid-SLN was higher than that of the stearyl alcohol-SLN, and its crystalinity increased in the sequence of vitamin A, C, and E. For the SLNs with stearic acid - TW80 at the mixing ratio of 1/2, the encapsulation of vitamin A, C, and E were 88.4%, 70.8%, and 93.5%, and the its releasing amount were 23.9%, 32.3%, and 48.1%, respectively. And for the SLNs with stearyl alcohol - TW80 at the mixing ratio of 1/2, the encapsulation of vitamin A, C, and E were 69.4%, 44.5%, and 92.4%, and the its releasing amount were 53.9%, 60.9%, and 88.9%, respectively.
The purpose of this study is to apply SLNs (solid lipid nanoparticles) loaded with active ingredients as epidermal carriers to the cosmetics. The particle size, stability, crystalline shape, crystallinity, encapsulation efficiency, and releasing amount of the prepared SLN were investigated according to the various type of lipids, surfactants, its mixing ratio, and active ingredients. The components of SLN were as follows ; the fatty acid were lauric acid, myristic acid, palmitic acid, and stearic acid, the long chain alcohols were lauryl alcohol, myristyl alcohol, cetyl alcohol, and stearyl alcohol, the hydrocarbon oils were dodecane, tetradecane, hexadecae and octadecane, the nonionic surfactants were TW20, TW40, TW60, and TW80. And the active ingredients were vitamin A, C, and E. The particle size of the SLN decreased according to the increase of the alkyl chain length of the lipids(C12, C14, C16, C18), the hydrophobic chain length of the surfactants (C14, C16, C18, C18-1), and in the sequence of 2/1, 1/1, 1/2 for mixing ratio of lipid and surfactant. Regardless of the chain length of the lipids, the surfactants, and its mixing ratio, the zeta potential values of the SLN for the fatty acids, the long chain alcohols, and the hydrocarbon oils were -30.0mV∼-50.0mV, -20.0mV∼ -40.0mV and -10.0mV∼-30.0mV, respectively. The particle size of the SLN, which was prepared with stearic acid, stearyl alcohol, and TW80, loaded with the active ingredients (vitamin A, C, and E) increased by 22.3% more than that of the unloaded SLN. The crystalliity of the stearic acid-SLN was higher than that of the stearyl alcohol-SLN, and its crystalinity increased in the sequence of vitamin A, C, and E. For the SLNs with stearic acid - TW80 at the mixing ratio of 1/2, the encapsulation of vitamin A, C, and E were 88.4%, 70.8%, and 93.5%, and the its releasing amount were 23.9%, 32.3%, and 48.1%, respectively. And for the SLNs with stearyl alcohol - TW80 at the mixing ratio of 1/2, the encapsulation of vitamin A, C, and E were 69.4%, 44.5%, and 92.4%, and the its releasing amount were 53.9%, 60.9%, and 88.9%, respectively.
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