Abstract ▼ AI-Helper

Suspension between dextrin and octacosanol in aqueous system was adopted to increase water dispersing of octacosanol. For preparing of octacosanol-dextrin dispersed formation, the octacosanol (100 mg) was mixed in 1% dextrin solution at 90 ℃ for 150 min and then cooling slowly for 12 hr at 25 ℃. Con...

Suspension between dextrin and octacosanol in aqueous system was adopted to increase water dispersing of octacosanol. For preparing of octacosanol-dextrin dispersed formation, the octacosanol (100 mg) was mixed in 1% dextrin solution at 90 ℃ for 150 min and then cooling slowly for 12 hr at 25 ℃. Contents of octacosanol were meagured using a gas chromatograph and characteristics of crystallinity was evaluated by XRD. In the complex was isolated by centrifugation, little V-crystalline structure was observed. For reducing loss and improving solubility of octacosanol, various treatments were performed such as stepwise addition, homogenizing, stirring and ethanol dissolution. When the octacosanol (20 mg) was added in dextrin solution by 5 times for 30 min intervals, reduction of loss was observed (76.2% → 17.6%). While the loss was increased to 30.7% by homogenizing, 12.1% and 13.4% for yields could be obtained by additional stirring (for 6 hr) and EtOH (2 ml) dissolution, respectively. After dissolving the octacosanol in EtOH (2 ml), the loss contents was reduced by additional stirring for 12 hr. The contents of octacosanol in supernatant by mild sonication (30 sec) from 24% to 47%. Therefore, it could be suggested that stepwise addition, dissolving octacosanol in EtOH additional stirring (12 hr) and mild sonication is good for improving the dispersibility of octacosanol in aqueous system.

주제어