Abstract ▼ AI-Helper

Schisandra chinensis Baill.is traditional oriental medicine. It commonly used for the treatment of insommia, noctyrnal enuresis, dysentery, cough, asthma, and jaundice. Repeated chromatography of n-hexane, EtOAc soluble fraction of the fruits of S.chinensis led to the isolation and chararacterizatio...

Schisandra chinensis Baill.is traditional oriental medicine. It commonly used for the treatment of insommia, noctyrnal enuresis, dysentery, cough, asthma, and jaundice. Repeated chromatography of n-hexane, EtOAc soluble fraction of the fruits of S.chinensis led to the isolation and chararacterization of ten lignans (1-10), four sesquiterpenes (11-14), three phenols (17-19), one alkaloid (16), one triterpenoid (15) known compounds. The structures were determined by spectroscopic data interpretation particularly by extensive 1D and 2D NMR studies. Among these isolated compounds, ρ-methoxycavacroland indole-3-acetic acid were isolated from the fruits of S. chinensis for the first time. This is the first time to report that β-chamigrenal, a sesquiterpenes, isolated from S. chinensis effectively inhibited the LPS-induced production of NO and PGE2 in RAW 264.7 macrophages.

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