I-124 has a half-life of 4.2 days, which makes it suitable for imaging over several days over its uptake and washout phases. However, it has a low positron branching ratio (23%), because high-energy γ- photons (602 to 1,691 keV), which degrade image quality, are emitted in cascade with positrons.The...
I-124 has a half-life of 4.2 days, which makes it suitable for imaging over several days over its uptake and washout phases. However, it has a low positron branching ratio (23%), because high-energy γ- photons (602 to 1,691 keV), which degrade image quality, are emitted in cascade with positrons.Therefore, the purpose of this dissertation was to develop I-124 PET optimal parameters for small animal PET. First, system and physical characteristics of Inveon PET system were evaluated using F-18, gold standard. We established the evaluation method based on the NEMA (National Electrical Manufacturers Association) NU4 standards. It was demonstrated that attenuation and scatter correction are necessary components of the artifact correction process for rat brain PET.In the examination of image quality to assess the effect of normalization for I-124 PET images, there were no differences in the non-uniformity and recovery coefficient between I-124 and Ge-68 normalization. Thus, conventional Ge-68 normalization could be applied to I-124 PET.To improve of I-124 PET image quality, the single gamma photon (SGF) was measured in various energy windows and developed correction method would be effective to correction of single gamma photon of I-124 PET due to considering of SGF within corresponding energy window. NECR (Noise Equivalent Count Rate) based optimal energy window for I-124 PET was assessed to compare image based result. Our data showed that optimal energy window should be determined according to assessment of image quality from reconstructed PET data. For I-124 PET, image quality was found to be affected by SOR (spill over ratio) of various energy windows and single gamma photon correction. In terms of the image quality of I-124 PET, our findings indicate that an energy window of 350~750 keV would be optimal.The method of single gamma photon correction and the image based energy window optimization were developed for the improvement of I-124 PET image quality, which will be useful to determine I-131injection activity since those methods offer the accurate information of internal dosimetry in I-131-radioimmunotherapy.
I-124 has a half-life of 4.2 days, which makes it suitable for imaging over several days over its uptake and washout phases. However, it has a low positron branching ratio (23%), because high-energy γ- photons (602 to 1,691 keV), which degrade image quality, are emitted in cascade with positrons.Therefore, the purpose of this dissertation was to develop I-124 PET optimal parameters for small animal PET. First, system and physical characteristics of Inveon PET system were evaluated using F-18, gold standard. We established the evaluation method based on the NEMA (National Electrical Manufacturers Association) NU4 standards. It was demonstrated that attenuation and scatter correction are necessary components of the artifact correction process for rat brain PET.In the examination of image quality to assess the effect of normalization for I-124 PET images, there were no differences in the non-uniformity and recovery coefficient between I-124 and Ge-68 normalization. Thus, conventional Ge-68 normalization could be applied to I-124 PET.To improve of I-124 PET image quality, the single gamma photon (SGF) was measured in various energy windows and developed correction method would be effective to correction of single gamma photon of I-124 PET due to considering of SGF within corresponding energy window. NECR (Noise Equivalent Count Rate) based optimal energy window for I-124 PET was assessed to compare image based result. Our data showed that optimal energy window should be determined according to assessment of image quality from reconstructed PET data. For I-124 PET, image quality was found to be affected by SOR (spill over ratio) of various energy windows and single gamma photon correction. In terms of the image quality of I-124 PET, our findings indicate that an energy window of 350~750 keV would be optimal.The method of single gamma photon correction and the image based energy window optimization were developed for the improvement of I-124 PET image quality, which will be useful to determine I-131injection activity since those methods offer the accurate information of internal dosimetry in I-131-radioimmunotherapy.
주제어
#소동물전용 양전자 방출 단층촬영 국제표준 성능평가 아이오다인-124 고에너지 단일감마선 영상품질 에너지 창 최적화 흘러넘침 비율 small animal PET NEMA NU3 performance measurement 124I high energy single gamma photon image quality energy widow optimization spill over ratio
학위논문 정보
저자
유아람
학위수여기관
Graduate School, Yonsei University
학위구분
국내박사
학과
Dept. of Radiological Science
지도교수
Hee Joung Kim
발행연도
2014
총페이지
xiii, 86장
키워드
소동물전용 양전자 방출 단층촬영 국제표준 성능평가 아이오다인-124 고에너지 단일감마선 영상품질 에너지 창 최적화 흘러넘침 비율 small animal PET NEMA NU3 performance measurement 124I high energy single gamma photon image quality energy widow optimization spill over ratio
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