The prevalence of childhood obesity has been rapidly increasing. In recent years, Evidences suggesting a role of polycyclic aromatic hydrocarbons (PAHs) in obesity has increased. And, environmental tobacco smoke (ETS) is another known risk factor of obesity. However, there were no studies that inves...
The prevalence of childhood obesity has been rapidly increasing. In recent years, Evidences suggesting a role of polycyclic aromatic hydrocarbons (PAHs) in obesity has increased. And, environmental tobacco smoke (ETS) is another known risk factor of obesity. However, there were no studies that investigated the interaction between the two on obesity. Therefore, we aimed to confirm the association between PAHs exposure and childhood obesity and to evaluate whether there are different effects of PAHs by severity of ETS exposure. We performed cross-sectional analyses of urinary PAH metabolites, anthropometric outcomes (body mass index percentile, waist circumference, waist to height ratio), body fat measures (android percent fat, gynoid percent fat, and android to gynoid fat ratio) by dual energy X-ray absorptiometry and obesity in 2152 children and adolescents, using the 2003-2008 National Health and Nutrition Examination Survey. In addition, the analyses were stratified by ETS exposure level (No ETS, mild ETS, medium, ETS, high ETS), measured by serum cotinine. After adjustment for ETS exposure and other confounding factors, most of association between PAH metabolites and adiposity measures had linear dose-response relationships. And the same, clear relationships were found for total PAH metabolites (all P values<0.01), which is summed concentration of all urinary PAH metabolites. In stratified analyses by presence of ETS exposure, means of adiposity measures were significantly increased with increasing quartiles of total PAH metabolites in both ETS exposed group and un-exposed group. If subgroup analyses were performed within ETS exposed group, the association between PAH and obesity strengthened with increasing severity of ETS exposure (all P for interactions<0.05). PAHs exposure was found to be positively associated with adiposity measures and obesity, and there was synergic interaction between PAHs and ETS. Our findings corroborate the hypothesis that PAHs might act as obesogens and further studies are required to evaluate the complicated interaction between PAHs and ETS.
The prevalence of childhood obesity has been rapidly increasing. In recent years, Evidences suggesting a role of polycyclic aromatic hydrocarbons (PAHs) in obesity has increased. And, environmental tobacco smoke (ETS) is another known risk factor of obesity. However, there were no studies that investigated the interaction between the two on obesity. Therefore, we aimed to confirm the association between PAHs exposure and childhood obesity and to evaluate whether there are different effects of PAHs by severity of ETS exposure. We performed cross-sectional analyses of urinary PAH metabolites, anthropometric outcomes (body mass index percentile, waist circumference, waist to height ratio), body fat measures (android percent fat, gynoid percent fat, and android to gynoid fat ratio) by dual energy X-ray absorptiometry and obesity in 2152 children and adolescents, using the 2003-2008 National Health and Nutrition Examination Survey. In addition, the analyses were stratified by ETS exposure level (No ETS, mild ETS, medium, ETS, high ETS), measured by serum cotinine. After adjustment for ETS exposure and other confounding factors, most of association between PAH metabolites and adiposity measures had linear dose-response relationships. And the same, clear relationships were found for total PAH metabolites (all P values<0.01), which is summed concentration of all urinary PAH metabolites. In stratified analyses by presence of ETS exposure, means of adiposity measures were significantly increased with increasing quartiles of total PAH metabolites in both ETS exposed group and un-exposed group. If subgroup analyses were performed within ETS exposed group, the association between PAH and obesity strengthened with increasing severity of ETS exposure (all P for interactions<0.05). PAHs exposure was found to be positively associated with adiposity measures and obesity, and there was synergic interaction between PAHs and ETS. Our findings corroborate the hypothesis that PAHs might act as obesogens and further studies are required to evaluate the complicated interaction between PAHs and ETS.
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#Polycyclic aromatic hydrocarbon 간접흡연 비만
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