Abstract ▼ AI-Helper

Delivery of macromolecules into tissues and cells such as skin is the most important in the study of drug delivery systems. Also, Excavating the material to study ligand and site of action is similar biological origin that specifically targets the receptor expressed on the surface of certain cells a...

Delivery of macromolecules into tissues and cells such as skin is the most important in the study of drug delivery systems. Also, Excavating the material to study ligand and site of action is similar biological origin that specifically targets the receptor expressed on the surface of certain cells a basis of in the development of treatments for cancer and specific diseases. The most basic and become, The easiest method for delivering a substance into cells would to utilize the same liposome with the cell membrane, in fact, the biological tissue has shown the limits that do not penetrate the epithelial layer. To overcome these limitations, have been accomplished many attempts to utilize the PTD protein. Especially, Hph-1 and PTD showed a highly effective skin penetration and intracellular movement peptide composed of short amino acid. Based on this, PTD hybrids were produced by combining a PTD peptide and the reporter gene GFP. Further, by producing a hybrid comprising a transmembrane protein region and Hph-1 of completing the efficacy evaluation and want to want to create a liposome complexes. In this study, in fact want to build a system to carry an effective drug target in the subcutaneous tissue through the PTD-TM-liposome complex. PTD hybrid showed the effect of moving into the cells through the cell membrane. Moreover, the pig skin tissue was confirmed that penetrated the epidermis and dermis layer through the stratum corneum. These results, PTD hybrid will be able to deliver effective substance that Wrinkles, blemishes, and whitening skin, such as skin beauty and being a direct target of atopic dermatitis, melanoma, skin cancer treatment.