천연성분인 해삼은 “바다의 인삼”이라 불릴정도로 사포닌성분이 많으며, 재생능력이 강하다. 그 외에도 chondroitins, tarurine, 비타민 A, C 등이 발견됐으나 두피나 탈모에관한 연구가 없어 두피관리시 안전하게 사용할 수 있을것을 기대하며 탈모 예방효과와 두피와 모발에 어떤 영향을 주는지 검증하고, 의약품과 같은 탈모 방지 및 발모제 개발 가능성을 제시하고자 하였다. 실험에 필요한 해삼을 추출 후 DPPH법(항산화 효과측정)을 사용 하여 ...
천연성분인 해삼은 “바다의 인삼”이라 불릴정도로 사포닌성분이 많으며, 재생능력이 강하다. 그 외에도 chondroitins, tarurine, 비타민 A, C 등이 발견됐으나 두피나 탈모에관한 연구가 없어 두피관리시 안전하게 사용할 수 있을것을 기대하며 탈모 예방효과와 두피와 모발에 어떤 영향을 주는지 검증하고, 의약품과 같은 탈모 방지 및 발모제 개발 가능성을 제시하고자 하였다. 실험에 필요한 해삼을 추출 후 DPPH법(항산화 효과측정)을 사용 하여 DPPH 용액에 해삼추출물을 첨가하고 섞은 다음 실온에서 일정기간동안 방치 후 흡광도의 세기를 측정하였다. 프리라디칼 소거활성(SC50)의 크기는 프리라디칼의 50%를 소거하는데 요구되는 해삼추출물의 양(ml)으로 나타냈다. 실험 결과 해삼 추출물의 양이 ① 0.5ml 일 경우 FRS 27.2%, ② 1ml 일 경우 FRS 47.1%, ③ 3ml 일 경우 FRS 79.9%, ④ 5ml 일 경우 FRS 90.8%로 나왔고, 그 결과 FRS가 5%일 경우에 항산화 효과가 가장 높다는 것을 알게 되었다. 해삼추출물을 사용하여 두피개선제를 제조 하였으며, 추출한 해삼성분이 5% 첨가된 두피개선제를 대조군과 실험군으로 나누어 일주일에 한 번씩 해삼추출성분으로 만든 두피개선제로 관리 하였고, 실험군에는 천연성분 해면가시 스피큘을 사용한 두피스크럽을 추가 관리 하였으며, 매주 관리시마다 Dino-lite 촬영과 유분, 수분, 미생물, 모발길이, 모발두께를 12주동안 두피 탈모개선 임상실험을 하였다. 해삼추출물 두피개선제 와 스크럽제를 사용한 두피관리에서 유분의 전·후 변화는 대조군 0주-6주 16.98% 증가하였으며, 6주-12주 39.84% 증가하였고, 실험군의 경우 0주-6주 51.48% 증가하였으며, 6주-12주 37.80% 증가하였고, 통계적으로 유의하게 나타났다.(p<0.05). 수분의 전·후 변화는 대조군 0주-6주 10.94% 증가하였고, 6주-12주 14.19% 증가하였으며, 실험군의 경우 0주-6주 21.19% 증가하였고, 6주-12주 3.33% 증가 하였다. 모발길이의 전·후 변화는 대조군 0주-6주 126.38% 증가하였고, 6주-12주 41.46% 증가하였으며, 실험군 0주-6주 229.73% 증가하였고, 6추-12주 47.15% 증가로 대조군과 실험군 모두 모발길이의 성장을 확인할 수 있었으며, 모발 굵기 의 전·후 변화는 대조군 0주-6주 5.66% 증가하였고, 6주-12주 1.79% 증가하였으며, 실험군의 경우 0주-6주 7.55% 증가하였고, 6주- 12주 8.77% 증가하였다. 짧은 기간이었지만 기존의 모발성장제와 거의 유사한 모발성장 효과를 나타내고 있으며, 미생물 양의 변화는 대조군 0주-6주 14.67% 증가하였고, 6주-12주 7.10% 증가하였으며, 실험군의 경우 0주-6주 17.22% 증가하였고, 6주-12주 14.59% 증가로 (p<0.05)나타났지만, 임상자들이 홈 케어 두피개선제 사용양의 부주위로 수치가 높아진 점을 무시할 수 없고, 문제성 두피개선과 모발성장의 과정으로 볼 때 미생물 수치의 의한 큰 걱정은 없을 것으로 사료 되며, 관리 중에 두피에 문제점들은 발생하지 않는 점을 고려할 때 기존의 탈모약제와 동일한 탈모방지 및 양모효과를 기대할 수 있으며, 두피관리제로서의 개발 가능성 또한 높다고 본다. 실험결과 해삼성분 두피개선제를 이용한 대조군과 실험군의 실험을 비교해보면 스피큘을 추가 관리한 실험군이 대조군에 비해 좀더 좋은 효과를 보였으며, 탈모 예방에 도움을 주고, 특히 해삼의 주성분인 Holothurin, 비타민 A, C가 모발의 수와 모발의 길이에 도움을 준다는 사실을 알게 되었으며, 기존 탈모약품의 부작용의 피부건조나 가려움증에도 좋은 효과를 보여 모발 화장품의 자료와 제품으로써 활용 가치뿐 아니라 해삼을 이용한 더 많은 가능성이 있다는 결론을 얻었다. 추후 장기간 실험 결과를 토대로 임상실험을 실시하여 결과 사례가 유사한지 살펴본다면 확실하게 안전하면서도 효능·효과가 입증된 화장품으로서의 탈모방지제로 개발가능성이 높다고 사료된다.
천연성분인 해삼은 “바다의 인삼”이라 불릴정도로 사포닌성분이 많으며, 재생능력이 강하다. 그 외에도 chondroitins, tarurine, 비타민 A, C 등이 발견됐으나 두피나 탈모에관한 연구가 없어 두피관리시 안전하게 사용할 수 있을것을 기대하며 탈모 예방효과와 두피와 모발에 어떤 영향을 주는지 검증하고, 의약품과 같은 탈모 방지 및 발모제 개발 가능성을 제시하고자 하였다. 실험에 필요한 해삼을 추출 후 DPPH법(항산화 효과측정)을 사용 하여 DPPH 용액에 해삼추출물을 첨가하고 섞은 다음 실온에서 일정기간동안 방치 후 흡광도의 세기를 측정하였다. 프리라디칼 소거활성(SC50)의 크기는 프리라디칼의 50%를 소거하는데 요구되는 해삼추출물의 양(ml)으로 나타냈다. 실험 결과 해삼 추출물의 양이 ① 0.5ml 일 경우 FRS 27.2%, ② 1ml 일 경우 FRS 47.1%, ③ 3ml 일 경우 FRS 79.9%, ④ 5ml 일 경우 FRS 90.8%로 나왔고, 그 결과 FRS가 5%일 경우에 항산화 효과가 가장 높다는 것을 알게 되었다. 해삼추출물을 사용하여 두피개선제를 제조 하였으며, 추출한 해삼성분이 5% 첨가된 두피개선제를 대조군과 실험군으로 나누어 일주일에 한 번씩 해삼추출성분으로 만든 두피개선제로 관리 하였고, 실험군에는 천연성분 해면가시 스피큘을 사용한 두피스크럽을 추가 관리 하였으며, 매주 관리시마다 Dino-lite 촬영과 유분, 수분, 미생물, 모발길이, 모발두께를 12주동안 두피 탈모개선 임상실험을 하였다. 해삼추출물 두피개선제 와 스크럽제를 사용한 두피관리에서 유분의 전·후 변화는 대조군 0주-6주 16.98% 증가하였으며, 6주-12주 39.84% 증가하였고, 실험군의 경우 0주-6주 51.48% 증가하였으며, 6주-12주 37.80% 증가하였고, 통계적으로 유의하게 나타났다.(p<0.05). 수분의 전·후 변화는 대조군 0주-6주 10.94% 증가하였고, 6주-12주 14.19% 증가하였으며, 실험군의 경우 0주-6주 21.19% 증가하였고, 6주-12주 3.33% 증가 하였다. 모발길이의 전·후 변화는 대조군 0주-6주 126.38% 증가하였고, 6주-12주 41.46% 증가하였으며, 실험군 0주-6주 229.73% 증가하였고, 6추-12주 47.15% 증가로 대조군과 실험군 모두 모발길이의 성장을 확인할 수 있었으며, 모발 굵기 의 전·후 변화는 대조군 0주-6주 5.66% 증가하였고, 6주-12주 1.79% 증가하였으며, 실험군의 경우 0주-6주 7.55% 증가하였고, 6주- 12주 8.77% 증가하였다. 짧은 기간이었지만 기존의 모발성장제와 거의 유사한 모발성장 효과를 나타내고 있으며, 미생물 양의 변화는 대조군 0주-6주 14.67% 증가하였고, 6주-12주 7.10% 증가하였으며, 실험군의 경우 0주-6주 17.22% 증가하였고, 6주-12주 14.59% 증가로 (p<0.05)나타났지만, 임상자들이 홈 케어 두피개선제 사용양의 부주위로 수치가 높아진 점을 무시할 수 없고, 문제성 두피개선과 모발성장의 과정으로 볼 때 미생물 수치의 의한 큰 걱정은 없을 것으로 사료 되며, 관리 중에 두피에 문제점들은 발생하지 않는 점을 고려할 때 기존의 탈모약제와 동일한 탈모방지 및 양모효과를 기대할 수 있으며, 두피관리제로서의 개발 가능성 또한 높다고 본다. 실험결과 해삼성분 두피개선제를 이용한 대조군과 실험군의 실험을 비교해보면 스피큘을 추가 관리한 실험군이 대조군에 비해 좀더 좋은 효과를 보였으며, 탈모 예방에 도움을 주고, 특히 해삼의 주성분인 Holothurin, 비타민 A, C가 모발의 수와 모발의 길이에 도움을 준다는 사실을 알게 되었으며, 기존 탈모약품의 부작용의 피부건조나 가려움증에도 좋은 효과를 보여 모발 화장품의 자료와 제품으로써 활용 가치뿐 아니라 해삼을 이용한 더 많은 가능성이 있다는 결론을 얻었다. 추후 장기간 실험 결과를 토대로 임상실험을 실시하여 결과 사례가 유사한지 살펴본다면 확실하게 안전하면서도 효능·효과가 입증된 화장품으로서의 탈모방지제로 개발가능성이 높다고 사료된다.
A natural ingredient “sea cucumber” contains so much saponin that it is often called the ginseng of the sea and has strong reproductivity. Besides it has been found that it contains chondroitin, taurine, vitamin A and C. But there has been no study on the sea cucumber related to scalp and hair loss....
A natural ingredient “sea cucumber” contains so much saponin that it is often called the ginseng of the sea and has strong reproductivity. Besides it has been found that it contains chondroitin, taurine, vitamin A and C. But there has been no study on the sea cucumber related to scalp and hair loss. This study is intended to confirm the safety of the extract of sea cucumber for scalp care, verify the hair loss prevention effect and effects of the extract of sea cucumber on scalp and hair and, present the possibility of developing anti-hair loss and hair growth solution. The extract of sea cucumber was dipped and mixed with DPPH solution. After the mixture was left at room temperature for a certain period of time, its absorbance was measured according to DPPH method. Free radical scavenging activity (SC50) was determined by the amount (ml) of the extract of sea cucumber required to eliminate free radical by 50%. The results have revealed that the antioxidant activity effect is the highest when FRS is 5%: ① FRS was 27.2% when the amount (ml) of the extract of sea cucumber was 0.5ml; ② FRS was 47.1% when the amount (ml) of the extract of sea cucumber was 1ml; FRS was 79.9% when the amount (ml) of the extract of sea cucumber was 3ml; ④ FRS was 90.8% when the amount (ml) of the extract of sea cucumber was 5ml. Scalp care solutions were formulated with the extract of sea cucumber. Control group and test group received the treatment of scalp care solutions containing 5% of extracts of sea cucumber once a week. Test group received additional treatment of scalp scrubs made with natural ingredients “spicule.” Whenever they received the treatment once a week, the conditions of scalp were recorded by a Dino-lite microscopic camera to analyze the sebum, moisture, microorganisms, length of hair, and thickness of hair for twelve weeks. After twelve weeks of treatment with scalp care solutions and scalp scrub containing the extract of sea cucumber, there appeared statistically-significant changes in the amount of sebum (p<0.05): the amount of sebum increased by 16.98% on week 0 to week 6 and by 39.84% on week 6 to week 12 in the control group and it increased by 51.48% on week 0 to week 6 and by 37.80% on week 6 to week 12 in the test group. There were changes in the amount of moisture: the amount of moisture increased by 10.94% on week 0 to week 6 and by 14.19% on week 6 to week 12 in the control group and it increased by 21.19% on week 0 to week 6 and by 3.33% on week 6 to week 12 in the test group. There were changes in the length of hair in both control group and test group: the length of hair increased by 126.38% on week 0 to week 6 and by 41.46% on week 6 to week 12 in the control group and it increased by 229.73% on week 0 to week 6 and by 47.15% on week 6 to week 12 in the test group. There were changes in the thickness of hair: the thickness of hair increased by 5.66% on week 0 to week 6 and by 1.79% on week 6 to week 12 in the control group and it increased by 7.55% on week 0 to week 6 and by 8.77% on week 6 to week 12 in the test group. Though it was a short period of time, the scalp care solutions and scalp scrub showed nearly similar effects to existing hair growth solutions. There were changes in the amount of microorganisms in both groups: the amount of microorganisms increased by 14.67% on week 0 to week 6 and by 7.10% on week 6 to week 12 in the control group and it increased by 17.22% on week 0 to week 6 and by 14.59% (p<0.05) on week 6 to week 12 in the test group. However, it is not negligible that the values increased owing to the mistake made by clinical investigators in determining the amount of scalp care solutions and scalp scrub. Judged from the process of scalp improvement and hair growth, it is believed that the increase in the amount of microorganisms doesn’t cause any significant problem. Given that any trouble didn’t appear on scalp during the treatment, it is expected that they will have the same hair-loss prevention and hair growth effect as existing hair solutions and have the high possibility for development of scalp care solutions. By analyzing the results from control group and test group, it is concluded that test group with the additional treatment of spicule shows a little better effects than control group on hair-loss prevention; Holothurin, vitamin A and C of main ingredients of sea cucumber have a significant influence on the amount and length of hair; as the extract of sea cucumber is helpful to mitigating skin dryness and itching, side effects of existing epilatioriums, they have a high possibility of utilization into ingredients of hair cosmetics and hair products. Therefore, it is thought that they have a great potential to be developed into safe and efficacy-and effect-proven hair-loss prevention solutions after clinical tests based upon the results of long-term experiments.
A natural ingredient “sea cucumber” contains so much saponin that it is often called the ginseng of the sea and has strong reproductivity. Besides it has been found that it contains chondroitin, taurine, vitamin A and C. But there has been no study on the sea cucumber related to scalp and hair loss. This study is intended to confirm the safety of the extract of sea cucumber for scalp care, verify the hair loss prevention effect and effects of the extract of sea cucumber on scalp and hair and, present the possibility of developing anti-hair loss and hair growth solution. The extract of sea cucumber was dipped and mixed with DPPH solution. After the mixture was left at room temperature for a certain period of time, its absorbance was measured according to DPPH method. Free radical scavenging activity (SC50) was determined by the amount (ml) of the extract of sea cucumber required to eliminate free radical by 50%. The results have revealed that the antioxidant activity effect is the highest when FRS is 5%: ① FRS was 27.2% when the amount (ml) of the extract of sea cucumber was 0.5ml; ② FRS was 47.1% when the amount (ml) of the extract of sea cucumber was 1ml; FRS was 79.9% when the amount (ml) of the extract of sea cucumber was 3ml; ④ FRS was 90.8% when the amount (ml) of the extract of sea cucumber was 5ml. Scalp care solutions were formulated with the extract of sea cucumber. Control group and test group received the treatment of scalp care solutions containing 5% of extracts of sea cucumber once a week. Test group received additional treatment of scalp scrubs made with natural ingredients “spicule.” Whenever they received the treatment once a week, the conditions of scalp were recorded by a Dino-lite microscopic camera to analyze the sebum, moisture, microorganisms, length of hair, and thickness of hair for twelve weeks. After twelve weeks of treatment with scalp care solutions and scalp scrub containing the extract of sea cucumber, there appeared statistically-significant changes in the amount of sebum (p<0.05): the amount of sebum increased by 16.98% on week 0 to week 6 and by 39.84% on week 6 to week 12 in the control group and it increased by 51.48% on week 0 to week 6 and by 37.80% on week 6 to week 12 in the test group. There were changes in the amount of moisture: the amount of moisture increased by 10.94% on week 0 to week 6 and by 14.19% on week 6 to week 12 in the control group and it increased by 21.19% on week 0 to week 6 and by 3.33% on week 6 to week 12 in the test group. There were changes in the length of hair in both control group and test group: the length of hair increased by 126.38% on week 0 to week 6 and by 41.46% on week 6 to week 12 in the control group and it increased by 229.73% on week 0 to week 6 and by 47.15% on week 6 to week 12 in the test group. There were changes in the thickness of hair: the thickness of hair increased by 5.66% on week 0 to week 6 and by 1.79% on week 6 to week 12 in the control group and it increased by 7.55% on week 0 to week 6 and by 8.77% on week 6 to week 12 in the test group. Though it was a short period of time, the scalp care solutions and scalp scrub showed nearly similar effects to existing hair growth solutions. There were changes in the amount of microorganisms in both groups: the amount of microorganisms increased by 14.67% on week 0 to week 6 and by 7.10% on week 6 to week 12 in the control group and it increased by 17.22% on week 0 to week 6 and by 14.59% (p<0.05) on week 6 to week 12 in the test group. However, it is not negligible that the values increased owing to the mistake made by clinical investigators in determining the amount of scalp care solutions and scalp scrub. Judged from the process of scalp improvement and hair growth, it is believed that the increase in the amount of microorganisms doesn’t cause any significant problem. Given that any trouble didn’t appear on scalp during the treatment, it is expected that they will have the same hair-loss prevention and hair growth effect as existing hair solutions and have the high possibility for development of scalp care solutions. By analyzing the results from control group and test group, it is concluded that test group with the additional treatment of spicule shows a little better effects than control group on hair-loss prevention; Holothurin, vitamin A and C of main ingredients of sea cucumber have a significant influence on the amount and length of hair; as the extract of sea cucumber is helpful to mitigating skin dryness and itching, side effects of existing epilatioriums, they have a high possibility of utilization into ingredients of hair cosmetics and hair products. Therefore, it is thought that they have a great potential to be developed into safe and efficacy-and effect-proven hair-loss prevention solutions after clinical tests based upon the results of long-term experiments.
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