Abstract ▼ AI-Helper

This study was conducted to evaluate risk and residual characteristics of Fluoroquinolones veterinary drugs on the Zebrafish (Danio rerio). The LC50 value of enrofloxacin in acute toxicity test for 48 hr was 70.90 ㎎ L-1(range: 66.75∼76.50 ㎎ L-1) and LC50 for 96 hr was 54.74 ㎎ L-1(51.95∼57.61). The L...

This study was conducted to evaluate risk and residual characteristics of Fluoroquinolones veterinary drugs on the Zebrafish (Danio rerio). The LC50 value of enrofloxacin in acute toxicity test for 48 hr was 70.90 ㎎ L-1(range: 66.75∼76.50 ㎎ L-1) and LC50 for 96 hr was 54.74 ㎎ L-1(51.95∼57.61). The LC50 of flumequine for 48 hr was 36.33 ㎎ L-1(28.85∼67.99 ㎎ L-1) and LC50 for 96 hr was 18.73 ㎎ L-1(17.43∼36.33).
Residual evaluation of both veterinary drugs in Zebrafish was studied after median lethal concentration(LC50) exposure for 96 hours. The maximal concentration of enrofloxacin in head, body, and viscera of Zebrafish were 46.69 ㎎ ㎏-1, 61.56 ㎎ ㎏-1, and 146.38 ㎎ ㎏-1, respectively. The maximal concentration of flumequine in head, body, and viscera of Zebrafish were 10.04 ㎎ ㎏-1, 8.61 ㎎ ㎏-1, and 62.03 ㎎ ㎏-1, respectively.
Residues of enrofloxacin showed tendency to increase with over time in viscera of Zebrafish, whereas flumequine showed tendency to decrease with over time. Residues of both veterinary drugs showed most accumulation in the viscera, also it resulted in more dead Zebrafish than alive ones.

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