Background: Mudan (Paeonia Suffruticosa Andr.) was the national flower of China in Qing dynasty. Although mudan has been used as medicine for a long history, there are only a few publications about its antioxidant and anti-inflammation, activities, and no studies reported the preventive effect of mu...
Background: Mudan (Paeonia Suffruticosa Andr.) was the national flower of China in Qing dynasty. Although mudan has been used as medicine for a long history, there are only a few publications about its antioxidant and anti-inflammation, activities, and no studies reported the preventive effect of mudan on UV-induced photoaging. This study was to investigate the preventive effects of mudan on UVB-induced skin photoaging for the purpose of developing novel applications in functional foods and cosmetics industry. Results: Results showed that mudan prevented UVB-induced photoaging in HaCaT cells, evidenced by decreased matrix metalloproteinases (MMPs) and increased collagen production. Gallic acid and paeonol were detected in mudan. Mudan significantly reduced UVB-induced phosphorylation of MAPK, which consequently decreased the activation of c-fos and c-jun. DLD was found to regulate the endogenous antioxidant system Nrf2/ARE. Mudan promoted the production of DLD, Nrf2, and ARE. In addition, the synergic effect of gallic acid and paeonol was studied. Among the GA/PA ratio (1:1, 5:1, 10:1, 1:5, and 1:10), the GA/PA (1:1) showed the best effects both in inhibiting MMP-1 production and promoting type I procollagen expression. Conclusion: The present study demonstrated that mudan prevented UVB-induced photoaging via inhibiting MAPK/AP-1 and activating DLD/Nrf2/ARE pathways. Gallic acid and paeonol were detected in both mudan flowers and roots. Specifically, mudan flower, rich in gallic acid, preferentially worked via decreasing the phosphorylation of MAPK/AP-1. Mudan root, rich in paeonol, was inclined to stimulate the activation of DLD/Nrf2/ARE. Gallic acid and paeonol mixture (1:1) showed the best preventive effect of photoaging due to their synergistic effects on MAPK/AP-1 and DLD/Nrf2/ARE pathways. Based on the present results, it showed that mudan was very effective in preventing skin photoaging. Therefore, mudan would be potential to develop new applications in cosmetics and functional foods industry.
Background: Mudan (Paeonia Suffruticosa Andr.) was the national flower of China in Qing dynasty. Although mudan has been used as medicine for a long history, there are only a few publications about its antioxidant and anti-inflammation, activities, and no studies reported the preventive effect of mudan on UV-induced photoaging. This study was to investigate the preventive effects of mudan on UVB-induced skin photoaging for the purpose of developing novel applications in functional foods and cosmetics industry. Results: Results showed that mudan prevented UVB-induced photoaging in HaCaT cells, evidenced by decreased matrix metalloproteinases (MMPs) and increased collagen production. Gallic acid and paeonol were detected in mudan. Mudan significantly reduced UVB-induced phosphorylation of MAPK, which consequently decreased the activation of c-fos and c-jun. DLD was found to regulate the endogenous antioxidant system Nrf2/ARE. Mudan promoted the production of DLD, Nrf2, and ARE. In addition, the synergic effect of gallic acid and paeonol was studied. Among the GA/PA ratio (1:1, 5:1, 10:1, 1:5, and 1:10), the GA/PA (1:1) showed the best effects both in inhibiting MMP-1 production and promoting type I procollagen expression. Conclusion: The present study demonstrated that mudan prevented UVB-induced photoaging via inhibiting MAPK/AP-1 and activating DLD/Nrf2/ARE pathways. Gallic acid and paeonol were detected in both mudan flowers and roots. Specifically, mudan flower, rich in gallic acid, preferentially worked via decreasing the phosphorylation of MAPK/AP-1. Mudan root, rich in paeonol, was inclined to stimulate the activation of DLD/Nrf2/ARE. Gallic acid and paeonol mixture (1:1) showed the best preventive effect of photoaging due to their synergistic effects on MAPK/AP-1 and DLD/Nrf2/ARE pathways. Based on the present results, it showed that mudan was very effective in preventing skin photoaging. Therefore, mudan would be potential to develop new applications in cosmetics and functional foods industry.
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