[학위논문]헤마토크릿과 혈액점도의 수치가 높은 개에서 방혈에 따른 혈액점도 변화에 관한 연구 A Study on the Change of Blood Viscosity with Phlebotomy in Dogs with High Value of Hematocrit and Blood Viscosity원문보기
Hematologic tests and serum biochemical tests that we usually perform are limited in the initial diagnosis of diseases such as vascular diseases and require an alternative method in itself by obtaining the rules by repeated experiments. On the other hand, whole blood viscosity(WBV) is determined...
Hematologic tests and serum biochemical tests that we usually perform are limited in the initial diagnosis of diseases such as vascular diseases and require an alternative method in itself by obtaining the rules by repeated experiments. On the other hand, whole blood viscosity(WBV) is determined by the interactions of blood cells such as erythrocytes and various plasma proteins, and it has characteristics of blood, which is a non-Newtonian liquid. Therefore, this is the main measure of hemodynamics in anlyzing blood flow. In this study, we have purpose to determine the significance of changes in WBV and related values by measuring WBV before and after phlebotomy in dogs with high WBV and hematocrit(HCT) value. A total of 10 neutralized beagle dogs were used, all of which were raised in the same environment and confirmed that low levels of CRP before and after phlebotomy did not lead to inflammation due to phlebotomy. Considering the mean and standard deviation of hematocrit in beagle dogs, groups with values greater than 50 were classified into the first group and those with lower values were into the second group, there were 5 dogs in each groups. In dogs with high blood viscosity (cP) and hematocrit values, all values except hemoglobin level (P = 0.048) were significant. Conversely, in dogs with hematocrit within normal range, most of the values including whole blood viscosity were significant. Therefore, this experiment shows that phlebotomy affects only dogs with hematocrit and whole blood viscosity of high level. After a large amount of blood loss, a voluntary compensatory reaction occurs. The initial reaction is splenic contraction, and the continuous reaction is the erythropoiesis reaction in the bone marrow. In the present experiment, hematocrit decreased significantly after 24 hours compared with immediately after hemorrhage and 24 hours after phlebotomy. On the contrary, fibrinogen showed more change after 24 hours than immediately after phlebotomy. therefore we were able to conform that there is splenic contraction. In addition, unlike the slight changes in hematocrit after 7 days, the blood viscosity returned to almost the original value, and the recovery of fibrinogen to a value similar to that of the previous one. It showed that Serum protein, such as fibrinogen, may contribute to the recovery of initial whole blood viscosity.
Hematologic tests and serum biochemical tests that we usually perform are limited in the initial diagnosis of diseases such as vascular diseases and require an alternative method in itself by obtaining the rules by repeated experiments. On the other hand, whole blood viscosity(WBV) is determined by the interactions of blood cells such as erythrocytes and various plasma proteins, and it has characteristics of blood, which is a non-Newtonian liquid. Therefore, this is the main measure of hemodynamics in anlyzing blood flow. In this study, we have purpose to determine the significance of changes in WBV and related values by measuring WBV before and after phlebotomy in dogs with high WBV and hematocrit(HCT) value. A total of 10 neutralized beagle dogs were used, all of which were raised in the same environment and confirmed that low levels of CRP before and after phlebotomy did not lead to inflammation due to phlebotomy. Considering the mean and standard deviation of hematocrit in beagle dogs, groups with values greater than 50 were classified into the first group and those with lower values were into the second group, there were 5 dogs in each groups. In dogs with high blood viscosity (cP) and hematocrit values, all values except hemoglobin level (P = 0.048) were significant. Conversely, in dogs with hematocrit within normal range, most of the values including whole blood viscosity were significant. Therefore, this experiment shows that phlebotomy affects only dogs with hematocrit and whole blood viscosity of high level. After a large amount of blood loss, a voluntary compensatory reaction occurs. The initial reaction is splenic contraction, and the continuous reaction is the erythropoiesis reaction in the bone marrow. In the present experiment, hematocrit decreased significantly after 24 hours compared with immediately after hemorrhage and 24 hours after phlebotomy. On the contrary, fibrinogen showed more change after 24 hours than immediately after phlebotomy. therefore we were able to conform that there is splenic contraction. In addition, unlike the slight changes in hematocrit after 7 days, the blood viscosity returned to almost the original value, and the recovery of fibrinogen to a value similar to that of the previous one. It showed that Serum protein, such as fibrinogen, may contribute to the recovery of initial whole blood viscosity.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.