Objectives: This study aimed to assess the effects of oral administration of deer antler and old antler extracts on an osteoporosis-induced animal model. We analyzed the results of using deer antler and old antler single extracts on animal models with osteoporosis through a systematic review and met...
Objectives: This study aimed to assess the effects of oral administration of deer antler and old antler extracts on an osteoporosis-induced animal model. We analyzed the results of using deer antler and old antler single extracts on animal models with osteoporosis through a systematic review and meta-analysis.
Methods: We included osteoporosis studies in animal experiments that administrated deer antler and old antler extracts orally. We searched the following 13 databases without a language restriction: PubMed, Embase, Cochrane Library, CINAHL, CNKI, Wanfang, KMbase, NDSL, Koreantk, OASIS, RISS, KISTI, and KISS. We used SYRCLE's Risk of Bias (RoB) tool for assessing the methodological quality of the included studies.
Results: A total of 297 potentially relevant studies were searched and 15 were included for a systematic review. Ten studies used a single deer antler extract and three used a single old antler extract. A study compared the effects of single extracts of deer antler and antler glue, while another study compared the effects of three single extracts of deer antler, old antler, and antler glue. The studies that could synthesize quantitative data were selected, and a meta-analysis was conducted by dividing the studies into those using a single deer antler extract and those using a single old antler extract. For evaluating the intervention effect, bone mineral density (BMD) was measured as the primary outcome, while the histomorphometric indicators of the bone and serum alkaline phosphatase (ALP) and osteocalcin levels were used as the secondary outcome variables. On conducting a meta-analysis of studies on single deer antler extract, BMD was observed to be significantly increased compared to that in control group (standardized mean difference [SMD]=1.92; 95% confidence interval [CI]=1.48-2.36; Z=8.51; p<0.00001; I2=18%). In the meta-analysis, bone volume/total volume measurement value increased significantly in the single deer antler extract administration group compared to the control group (SMD=1.07; 95% CI=0.48-1.67; Z=3.54; p=0.0004; I2=0%). The trabecular number was significantly increased in the single deer antler extract administration group compared to the control group (SMD=1.36; 95% CI=0.74-1.98; Z=4.28; p<0.0001; I2=0%). In addition, the trabecular separation was significantly decreased in the single deer antler extract administration group compared to the control group (SMD=-1.63; 95% CI=-2.3 to -0.95; Z=4.69; p<0.00001; I2=0%). There was no statistically significant difference in serum ALP and osteocalcin levels between the single antler extract administration and control groups.
A meta-analysis was also conducted on the experimental study using a single old antler extract. Consequently, BMD was significantly increased compared to that in the control group (SMD=1.77; CI=0.94-2.61; Z=4.16; p<0.001; I2=0%). However, there was no statistically significant difference in serum ALP and osteocalcin levels between the single old antler extract administration and control groups.
Conclusions: The research shows that the deer antler and old antler extracts have significant anti-osteoporotic effects on the osteoporosis-induced animal model. However, according to SYRCLE's RoB tool assessment, the studies included in this research had a high methodological risk of bias. This indicates the requirement of considerable attention in the interpretation of the study results. Thus, more methodologically high-quality studies are required in the future.
Objectives: This study aimed to assess the effects of oral administration of deer antler and old antler extracts on an osteoporosis-induced animal model. We analyzed the results of using deer antler and old antler single extracts on animal models with osteoporosis through a systematic review and meta-analysis.
Methods: We included osteoporosis studies in animal experiments that administrated deer antler and old antler extracts orally. We searched the following 13 databases without a language restriction: PubMed, Embase, Cochrane Library, CINAHL, CNKI, Wanfang, KMbase, NDSL, Koreantk, OASIS, RISS, KISTI, and KISS. We used SYRCLE's Risk of Bias (RoB) tool for assessing the methodological quality of the included studies.
Results: A total of 297 potentially relevant studies were searched and 15 were included for a systematic review. Ten studies used a single deer antler extract and three used a single old antler extract. A study compared the effects of single extracts of deer antler and antler glue, while another study compared the effects of three single extracts of deer antler, old antler, and antler glue. The studies that could synthesize quantitative data were selected, and a meta-analysis was conducted by dividing the studies into those using a single deer antler extract and those using a single old antler extract. For evaluating the intervention effect, bone mineral density (BMD) was measured as the primary outcome, while the histomorphometric indicators of the bone and serum alkaline phosphatase (ALP) and osteocalcin levels were used as the secondary outcome variables. On conducting a meta-analysis of studies on single deer antler extract, BMD was observed to be significantly increased compared to that in control group (standardized mean difference [SMD]=1.92; 95% confidence interval [CI]=1.48-2.36; Z=8.51; p<0.00001; I2=18%). In the meta-analysis, bone volume/total volume measurement value increased significantly in the single deer antler extract administration group compared to the control group (SMD=1.07; 95% CI=0.48-1.67; Z=3.54; p=0.0004; I2=0%). The trabecular number was significantly increased in the single deer antler extract administration group compared to the control group (SMD=1.36; 95% CI=0.74-1.98; Z=4.28; p<0.0001; I2=0%). In addition, the trabecular separation was significantly decreased in the single deer antler extract administration group compared to the control group (SMD=-1.63; 95% CI=-2.3 to -0.95; Z=4.69; p<0.00001; I2=0%). There was no statistically significant difference in serum ALP and osteocalcin levels between the single antler extract administration and control groups.
A meta-analysis was also conducted on the experimental study using a single old antler extract. Consequently, BMD was significantly increased compared to that in the control group (SMD=1.77; CI=0.94-2.61; Z=4.16; p<0.001; I2=0%). However, there was no statistically significant difference in serum ALP and osteocalcin levels between the single old antler extract administration and control groups.
Conclusions: The research shows that the deer antler and old antler extracts have significant anti-osteoporotic effects on the osteoporosis-induced animal model. However, according to SYRCLE's RoB tool assessment, the studies included in this research had a high methodological risk of bias. This indicates the requirement of considerable attention in the interpretation of the study results. Thus, more methodologically high-quality studies are required in the future.
주제어
#Osteoporosis Animal model Deer antler Old antler Systematic review Meta-analysis
※ AI-Helper는 부적절한 답변을 할 수 있습니다.