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Abstract ▼ AI-Helper

Labelling auflatoxines, the potential carcinogenic compounds, by radioactive iodine has been studied. The auflatoxine-$B_1$, which is known to be the most abundant components of auflatoxines in the nature, was labelled by radioactive iodine-125 through an acid catalyst chloroamine-T proce...

Labelling auflatoxines, the potential carcinogenic compounds, by radioactive iodine has been studied. The auflatoxine-$B_1$, which is known to be the most abundant components of auflatoxines in the nature, was labelled by radioactive iodine-125 through an acid catalyst chloroamine-T procedure. The radiochemical yield was amounted to 63.6%. The chemical structure of the labelled product was proved to be 6-iodo 5-methoxy coumarine structure of auflatoxine-$B_1$ molecule by means of I.R. and N.M.R. spectroscopy. The labelled product was orally administered in a test animal (Rat) and examined the accumnulation of radioactivity in the body at the definite time interval. The accumnulation of the radioactivity was pronounced at the blood and the liver. There was no indication of the decomposition of auflatoxine-$B_1-^{125}I$ in the organs of the test animal.