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Abstract ▼ AI-Helper

(1). When experimental rats were fed with fats either with ginseng saponin (0.05 mg/rat) or without the saponin, the blood serum lipids of both groups were found increased gradually on time course and no appreciable difference in the absorption patten between the two groups could be observed. Howeve...

(1). When experimental rats were fed with fats either with ginseng saponin (0.05 mg/rat) or without the saponin, the blood serum lipids of both groups were found increased gradually on time course and no appreciable difference in the absorption patten between the two groups could be observed. However, in cannulated rats, in which the secretion of bile and pancreatic juice into small intestine was impaired, the absorption of fats was greatly stimulated in the saponin fed (0.05 mg/rat) group suggesting that even the small amount of ginseng saponin greatly favoured for the lipid absorption in the absence or at the shortage of bile and pancreatic juice. (2). It was demonstrated that the highest radioactivity of blood lipid of ginseng administered rats appeared ealier (at 3 hrs.) than control (at 5 hrs.) after radioactive glycerol-tri (1-$^{14}C$)-palmitate feeding. The value of radioactivity was also much higher it test group on time course after the radioactive fat feeding and the highest peak appeared earlier than that of control rats. In the 4-$^{14}C$-cholesterol fed animals, the highest activity of both blood serum and liver lipids of ginseng administered rats appeared 6 hr. after the feeding but no significantly high radioactivity in control was observed during the experimental period. This results suggest that ginseng saponin stimulated fats and cholesterol absorption and transport. (3). The radioactivity-time course data of hepatic fatty acids of ginseng treated rats for two weeks-prior to glycerol-tri (1-$^{14}C$)-palmitate administration showed that the highest peak of the radio-activity appeared faster (3 hr. after the feeding) than that (5 hr. after) of control group. Furthermore the radioactivity of non-lipid fraction of the liver of test group was much higher than that of control group. In the liver of ginseng treated rats prior to 4-$^{14}C$-cholesterol administration, the highest was observed at 4 hr. after the isotope feeding while no appeciable radioactivity peak can be observed in control group during the experimental period. This suggests that the saponin stimulates fatty acid and cholesterol metabolism.