초록

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Abstract ▼ AI-Helper

The petroleum ether fraction from Korean Ginseng roots has been proved to be cytotoxic to murine lymphocytic leukemia L5178Y cells and murine Sarcoma 180 cells. This petroleum ether fraction which was extracted from Korean ginseng roots inhibited the growth of murine leukemia L5178Y cells and murine...

The petroleum ether fraction from Korean Ginseng roots has been proved to be cytotoxic to murine lymphocytic leukemia L5178Y cells and murine Sarcoma 180 cells. This petroleum ether fraction which was extracted from Korean ginseng roots inhibited the growth of murine leukemia L5178Y cells and murine Sarcoma 180 cells in vitro. And it also inhibited DNA, RNA and protein synthesis in murine ascitic Sarcoma 180 cells in vitro. The cytotoxicity of this fraction and it's inhibitory effect on biosynthesis of macromolecules were exponential function of its concentration. The cytotoxicity correlated to the inhibitory effect on the biosynthesis of macromolecules, especially to the inhibitory action on protein synthesis. The inhibitory action of this fraction on the protein synthesis was due to the inhibition of polysome formation: at the concentration which causes 90% inhibition of protein synthesis all the polysomes were dissociated into monosomes. Since messenger RNA degradation was not occurred at this concentration, petroleum ether fraction seems to interfere specifically the initiation of polypeptide synthesis.