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Abstract ▼ AI-Helper

The toxic lectin, ricin, present in the seeds of Korean castor bean, Ricinus communis, have been isolated and the biochemical properties were studied. The isolation procedure involves ion exchange chromatography on DEAE-cellulose, affinity chromatography on Sepharose 4B column. The multiplication ra...

The toxic lectin, ricin, present in the seeds of Korean castor bean, Ricinus communis, have been isolated and the biochemical properties were studied. The isolation procedure involves ion exchange chromatography on DEAE-cellulose, affinity chromatography on Sepharose 4B column. The multiplication rate of $K_{562}$ cell decreased and the death rate increased proportionally by the addition of the isolated ricin. It has hemagglutination activity but only 0.3% of the activity of the other lectin, ricinus agglutinin. The activity was inhibited by lactose, melibiose, galactose as well as ${\alpha}-L-rhamnose$ and L-arabinose. A dose of 60 ng of ricin caused death in 50% after 4 days in ICR mice.