[논문]Complexation of Amphotericin B With Egg Phosphatidylcholine Liposomes

Kim, Jin-Chul; Lee, Eun-Ok; Yang, Ji-Won; Choe, Tae-Boo; Kim, Jong-Duk

doi:10.1007/bf02979139

Complexation of Amphotericin B With Egg Phosphatidylcholine Liposomes 원문보기

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.18 no.2, 1995년, pp.84 - 89

Kim, Jin-Chul (Department of Chemical Engineering and Bioprocess Engineering Research Center, Korea Advanced Institute of Science and Technology) , Lee, Eun-Ok (Department of Chemical Engineering and Bioprocess Engineering Research Center, Korea Advanced Institute of Science and Technology) , Yang, Ji-Won (Department of Chemical Engineering and Bioprocess Engineering Research Center, Korea Advanced Institute of Science and Technology) , Choe, Tae-Boo (Department of Microbial Engineering, University of Konkuk) , Kim, Jong-Duk (Department of Chemical Engineering and Bioprocess Engineering Research Center, Korea Advanced Institute of Science and Technology)

Abstract ▼ AI-Helper

The complexation and physical characteristics of egg phosphatidylcholine (PC) liposome containing amphotericin B(AmB) were investigated through circular dichrosim(CD) spectra, the size distribution, the turbidity change, and the calcein release. CD spectra of AmB-containing egg PC mxture exhibited a positive peak around 330 nm indicative of complexation of AmB and four negative peaks. The positive peak increased up to $2.2{\;}millidegree/{\mu}g$ AmB as AmB contents increased up to 12% (w/w), suggesting that AmB-phospholipid complexation was promoted by the antibiotics. The effective diameter of liposomesa by dynamic light scattering decreased from 450 nm to 220 nm as the amount of AmB in liposomes increased from o to 30% (w/w). The complexation may be responsible for the reduction in size. On the other hand, at around 1 mN deoxycholate (DOC), the reltive turbidities of 5 and 10% (w/w) AmB-containing liposome suspension were less than 1 probably due to the soblubilization of the complex, while those of pure PC liposome suspension were larger than 1 at the same concentration. Deoxycholate-induced release of liposomes, indicating the intercalation of the drug into the bilayers. Therefore, it is concluded that in AmB/eggPC/water system, AmB-phospholipid complexcoexists with AmB-containing liposomes.

주제어

참고문헌 (23)

Ann. Intern. Med. J. E. Edwards 89 91 1978 10.7326/0003-4819-89-1-91 Edwards, J. E., Lehrer, R. I., Stiehm, E. R., Fischer, T. J. and Young, L. S., Severe candidal infections: Clinical perspective, immune defense mechanisms, and current concepts of therapy.Ann. Intern. Med., 89, 91-106 (1978).

상세보기
Rev. Infect. Dis. R. Horn 7 646 1985 10.1093/clinids/7.5.646 Horn, R., Wong, B., Kiehn, T. E. and Amstrong, D., Fungemia in scancer hospital: Changing frequency, earlier onset, and results of therapy.Rev. Infect. Dis., 7, 646-655 (1985).
Biochim. Biophys. Acta. R. Metha 770 230 1984 10.1016/0005-2736(84)90135-4 Metha, R., Lopez-Berestein, G., Hopfer, R., Mills, K. and Juliano, R.L., Liposomal amphotericin B is toxic to fungal cells but not to mammalian cells.Biochim. Biophys. Acta., 770, 230-243 (1984).

상세보기
Biochim. Biophys. Acta. D. B. Archer 436 68 1976 10.1016/0005-2736(76)90220-0 Archer, D. B., Effect of the lipid composition ofmycoplasma mycoides subspecies capri and phosphatidylcholine vesicles upon the action of polyene antibiotics.Biochim. Biophys. Acta., 436, 68-76 (1976).

상세보기
Biochemistry W. C. Chen 16 4145 1977 10.1021/bi00638a002 Chen, W. C. and Bittman, R., Kinetics of association of amphotericin B with vesicle.Biochemistry, 16, 4145-4149 (1977).

상세보기
Biochem. Biophys. Res. Commun. A. Vertut-Croquin 125 360 1984 10.1016/S0006-291X(84)80376-9 Vertut-Croquin, A., Bolard, J. and Gary-Bobo, C. M., Enhancement of amphotericin B selectivity by antibiotic incorporation into gel state vesicles: A circular dichroism and permeability study.Biochem. Biophys. Res. Commun., 125, 360-366 (1984).

상세보기
Biochim. Biophys. Acta. V. E. Khutorsky 1108 123 1992 10.1016/0005-2736(92)90015-E Khutorsky, V. E., Structure of amphotericin B-cholesterol complex.Biochim. Biophys. Acta., 1108, 123-127 (1992).

상세보기
Biochim. Biophys. Acta. P. V. Hoogevest 511 397 1978 10.1016/0005-2736(78)90276-6 Hoogevest, P. V. and Kruijff, B. D., Effect of amphotericin B on cholesterol-containing liposomes of egg phosphatidylcholine and didocosenoyl phosphatidylcholine.Biochim. Biophys. Acta., 511, 397-407 (1978).

상세보기
Biochim. Biophys. Acta. B. De Kruijff 339 44 1974 10.1016/0005-2736(74)90331-9 De Kruijff, B. and Demel, R. A., Polyene antibioticssterol interaction of acholeplasma laidlawii cells and lecithin liposomes.Biochim. Biophys. Acta., 339, 44-56 (1974).

상세보기
Biochemistry R. Bittman 13 1364 1974 10.1021/bi00704a009 Bittman, R., Chen, W. C. and Anderson, O. R., Interaction of filipin III and amphotericin B with lecithin-sterol vesicle and cellular membrane: Spectral and electron microscope studies.Biochemistry, 13, 1364-1373 (1974).

상세보기
J. Infect. Dis. V. Joly 165 337 1992 10.1093/infdis/165.2.337 Joly, V., Saint-Pierre-Chazalet, M., Saint-Julien, L., Bolard, J., Carbon, C. and Yeni, P., Inhibiting cholesterol synthesis reduces the binding and toxicity of amphotericin B against renal tubular cells in primary culture.J. Infect. Dis., 165, 337-343 (1992).

상세보기
G. Lopez-Berestein 253 1987 Liposomes: From Biophysics to Therapeutics Lopez-Berestein, G. and Juliano, R. L., Application of liposomes to the delivery of antifungal agents, in Ostro, M. J. (Ed),Liposomes: From Biophysics to Therapeutics, Marcel Dekker, New York, 1987, pp. 253-276.
J. Infect. Dis. G. Lopez-Berestein 147 939 1983 10.1093/infdis/147.5.939 Lopez-Berestein, G., Mehta, R., Hopfer, R. L., Mills, K., Kasi, L., Mehta, K., Fainstein, V., Luna, M., Hersh, E. M. and Juliano, R., Treatment and prophylaxis of disseminated infection due to candida albicans in mice with liposome-encapsulated amphotericin B.J. Infect. Dis., 147, 939-944 (1983).

상세보기
Antimicrob. Agents Chemother C. Tremblay 26 170 1984 10.1128/AAC.26.2.170 Tremblay, C., Barza, M., Fiore, C. and Szoka, F., Efficacy of liposome-encapsulated amphotericin B in the treatment of systemic candidiasis in mice.Antimicrob. Agents Chemother, 26, 170-173 (1984).

상세보기
J. Infect. Dis. G. Lopez-Berestein 151 704 1985 10.1093/infdis/151.4.704 Lopez-Berestein, G., Fainstein, V. and Hopfer, RM., Liposomal amphotericin B for the treatment of systemic fungal infections in patient with cancer: A preliminary study.J. Infect. Dis., 151, 704-710 (1985).

상세보기
Biochim. Biophys. Acta. W. R. Perkins 1107 271 1992 10.1016/0005-2736(92)90414-H Perkins, W. R., Minchey, S. R., Boni, L. T., Swenson, C. E., Popescu, M. C., Pasternack, R. F. and Janoff, A. S., Amphotericin B-phospholipid interactions responsible for reduced mammalian cell toxicity.Biochim. Biophys. Acta., 1107, 271-282 (1992).

상세보기
J. Biochemistry (Japan) J. G. Kim 110 436 1991 10.1093/oxfordjournals.jbchem.a123599 Kim, J. G. and Kim, J.-D., Vesicle to micelle transitions of phosphatidylcholine liposome induced by nonionic surfactant, poly(oxyethylene) cetyl ether.J. Biochemistry (Japan), 110, 436-442 (1991).

상세보기
J. Biochemistry (Japan) E. O. Lee 112 671 1992 10.1093/oxfordjournals.jbchem.a123957 Lee, E. O., Kim, J. G. and Kim, J.-D., Induction of vesicle-to-micelle transition by bile salts for DOPE vesicle incorporating immunoglobulin G.J. Biochemistry (Japan), 112, 671-676 (1992).

상세보기
Biochim. Biophys. Acta. J. Borlard 599 280 1980 10.1016/0005-2736(80)90074-7 Borlard, J., Seigneret, M. and Boudet, G., Interaction between phospholipid bilayer membranes and the polyene antibiotic amphotericin B: Lipid state and cholesterol content dependence.Biochim. Biophys. Acta., 599, 280-293 (1980).

상세보기
Biochemistry R. Schubert 25 5263 1986 10.1021/bi00366a042 Schubert, R., Beyer, K., Hartwig and Schmidt, K., Structural change in membrane of large unilamellar vesicles after binding of sodium cholate.Biochemistry, 25, 5263-5269 (1986).

상세보기
Biochemistry R. Schubert 27 8787 1988 10.1021/bi00424a015 Schubert, R. and Schmidt, K., Structural change in vesicle membrane and mixed micelles of various lipid compositions after binding of different bile salts.Biochemistry, 27, 8787-8794 (1988).

상세보기
Proc. Natl. Acad. Sci. A. S. Janoff 85 6122 1986 10.1073/pnas.85.16.6122 Janoff, A. S., Boni, L. T., Popescu, M. C., Minchey, S. R., Cullis, P. R., Madden, T. D., Taraschi, T., Gruner, S. M., Shyamsunder, E., Tate, M. W., Mendelsohn, R. and Bonner, D., Unusual lipid structures selectively reduce the toxicity of amphotericin B.Proc. Natl. Acad. Sci., 85, 6122-6126 (1986)

상세보기
Cancer Drug Delivery G. Lopez-Berestein 1 37 1983 10.1089/cdd.1983.1.37 Lopez-Berestein, G., Mehta, R., Hopfer, R., Mehta, K., Hersh, E. M. and Juliano, R., Effect of sterols on the therapeutic efficacy of liposomal amphotericin B in murine candidiasis.Cancer Drug Delivery, 1, 37-42 (1983).

상세보기

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Complexation of Amphotericin B With Egg Phosphatidylcholine Liposomes 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (23)

이 논문을 인용한 문헌

저자의 다른 논문 :

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

Complexation of Amphotericin B With Egg Phosphatidylcholine Liposomes 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (23)

이 논문을 인용한 문헌

저자의 다른 논문 :

양지원 (40) 김종득 (13)

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트