$A_{23187}$과 2가 이온에 의해 일어나는 $K^{+}$ 이온과 $H^{-}$ 이온의 흐름에 미치는 Triterpenoidal Dammarane Serids의 Glycosides와 그 Aglycones의 영향 The Action of Triterpenoidal Glycosides of Dammarane Series and Their Aglycones on $K^{+}$ and $H^{-}$ Fluxes in Erythrocytes, Induced by lonophore $A_{23187}$ and Divalent ions원문보기
Kim, Yu.A.
(Institute of Cell Biophysics, Russian Acadeny of Science)
,
Park, Kyeong-Mee
(Korea Ginseng & Tobacco Research Institute,Department of Biochemical Pharmacology)
,
Kyung, Jong-Su
(Korea Ginseng & Tobacco Research Institute,Department of Biochemical Pharmacology)
,
Hyun, Hak-Chul
(Korea Ginseng & Tobacco Research Institute,Department of Biochemical Pharmacology)
,
Song, Yong-Bum
(Korea Ginseng & Tobacco Research Institute,Department of Biochemical Pharmacology)
,
Shin, Han-Jae
(Korea Ginseng & Tobacco Research Institute,Department of Biochemical Pharmacology)
,
Park, Hwa-Jin
(Department of Medical Laboratory Science, College of Health Science, Inje University)
Ginsenoside Rb,, at a concentration of 10 $\mu\textrm{g}$/ml and over, initiated the cycle of oscillation of ion flux in erythrocytes after the cells had been treated with a protonophore, carbonyl cyanide p-trifluoro-methoxyphenyl hydrazone (FCCP) and then with a $Ca^{2+}$ iono...
Ginsenoside Rb,, at a concentration of 10 $\mu\textrm{g}$/ml and over, initiated the cycle of oscillation of ion flux in erythrocytes after the cells had been treated with a protonophore, carbonyl cyanide p-trifluoro-methoxyphenyl hydrazone (FCCP) and then with a $Ca^{2+}$ ionophore, A23,3,. Its action was similar to the additional portion of $Ca^{2+}$-ionophore or $Ca^{2+}$ ion to the erythrocytes. Effects of $Rg_1$ and Rf were different from that of Rb,. They did not induce the oscillation. They, however, increased the extracellular $K^{+}$ concentration and pH without returning to the initial state in the erythrocytes processed with FCCP and $A_{23187}$. We established that ginsenosides from 20-(5)-panaxatriol family induced the membrane hyperpolarization in erythrocytes, which was attenuated by the pretreatment of $Rb_1$, a major component of 20-(5)-panaxadiol.
Ginsenoside Rb,, at a concentration of 10 $\mu\textrm{g}$/ml and over, initiated the cycle of oscillation of ion flux in erythrocytes after the cells had been treated with a protonophore, carbonyl cyanide p-trifluoro-methoxyphenyl hydrazone (FCCP) and then with a $Ca^{2+}$ ionophore, A23,3,. Its action was similar to the additional portion of $Ca^{2+}$-ionophore or $Ca^{2+}$ ion to the erythrocytes. Effects of $Rg_1$ and Rf were different from that of Rb,. They did not induce the oscillation. They, however, increased the extracellular $K^{+}$ concentration and pH without returning to the initial state in the erythrocytes processed with FCCP and $A_{23187}$. We established that ginsenosides from 20-(5)-panaxatriol family induced the membrane hyperpolarization in erythrocytes, which was attenuated by the pretreatment of $Rb_1$, a major component of 20-(5)-panaxadiol.
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