Purpose : To understand MR imaging characteristics, of abscesses by correlation with pathologic findings, withemphasis on the hypointense rim of the abscess wall on T2-weighted images. Materials and Methods : Weexperimentally induced twenty abscesses on both thighs of ten New Zealand white rabbits by innoculation of E.coli. Spin-echo axial T1-weighted images(T1WI), proton density weighted images(PDWI), T2-weighted images(T2WI) andgadolinium enhanced T1WI of two rabbits were each obtained at 1 and 3 days, and at 1, 2 and 4 weeks followinginnoculation of pathogens. Rabbits were sacrificed after MR imaging, and freezing, sectioning along MR imagingplanes and histopathologic examination were subsequently carried out. MR-pathologic correlation was performed,with emphasis on the MR signal characteristics of the abscess wall. Results : In 19 abscesses, necrotic portionsexcept gas showed hypointensity or hyperintensity on T1WI and hyperintensity on T2WI. Peripheral inflammatoryreaction showed hypointensity on T1WI, hyperintensity on PDWI and T2WI, and contrast enhancement. Abscess wallshowed slightly increased signal intensity on T1WI. A hypointense rim on PDWI and T2WI appeared from 3 days afterpathogen innoculation. The rim was thickest at 1 week, and showed multilayers at 2 weeks and double layers at 4weeks after pathogen innoculation. Cellular and necrotic debris was accumulated at the inner portion of theabscess wall. Inflammatory cells were mainly polymorphonuclear leukocytes and lymphocytes. Macrophages, whichappeared at 3 days, suggested active phagocytosis at 1 week after innoculation. Thereafter, inflammatory reactionsdecreased and fibrosis progressed. Conclusion : The hypointense rim of the abscess wall on T2WI reflects theaccumulation of cellular debris, the paramagnetic effect of free radicals due to active phagocytosing macrophagesduring the abscess forming stage, and fibrosis during the maturation stage.
원문 PDF 다운로드
원문 URL 링크
원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)
DOI 인용 스타일