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1. Biochemistry M. D. Berardini 32 3306 1993 10.1021/bi00064a013 Berardini, M. D., Souhami, R. L., Lee, C.-S., Gibson, N. W., Butler, J., and Hartley, J. A. Two structually related diaziridinylbenzoquinones preferentially cross-link DNA at different sites upon reduction with DT-diaphorase.Biochemistry, 32, 3306-3312 (1993). 

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2. Anti-Cancer Drug Design Z.-M. Ding 6 427 1992 Ding, Z.-M., and Hurley, L. H. DNA interstrand cross-linking, DNA sequence specificity, and induced conformational changes produced by a dimeric analog of (+)-CC-1065.Anti-Cancer Drug Design, 6, 427-452 (1992). 

3. J. Antibiot. L. J. Hanka 31 1211 1978 10.7164/antibiotics.31.1211 Hanka, L. J., Dietz, A., Gerpheide, S. A., Kuentzel, S. L., and Martin, D. G. CC-1065 (NSC-298223), a new antitumor antibiotic, production in vitro biological activity, microbiological assay and taxonomy of the producing microorganism.J. Antibiot., 31, 1211-1217 (1978). 

   

4. Science L. H. Hurley 226 843 1984 10.1126/science.6494915 Hurley, L. H., Reynolds, V. L., Swenson, D. H., Petzold, G. L., and Scahill, T. A. Reaction of the antitumor antibiotic CC-1065 with DNA. Structure of a adduct with DNA sequence specificity.Science, 226, 843-844 (1984). 

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5. Cancer Res. C.-S. Lee 51 6586 1991 Lee, C.-S., and Gibson, N. W. DNA damage and differential cytotoxicity produced in human carcinoma cells by CC-1065 analogues, U-73,975 and U-77,779.Cancer Res., 51, 6586-6591 (1991). 

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6. Biochemistry C.-S. Lee 32 2592 1993 10.1021/bi00061a017 Lee, C.-S., and Gibson, N. W. Nucleotide preference for DNA interstrand cross-linking induced by cyclopropylpyrroloindole analogue, U-77,779.Biochemistry, 32, 2592-2600 (1993a). 

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7. Biochemistry C.-S. Lee 32 9108 1993 10.1021/bi00086a015 Lee, C.-S., and Gibson, N. W. DNA interstrand cross-links induced by the cyclopropylpyrroloindole antitumor agent U-77,779 are reversible upon exposure to alkali.Biochemistry, 32, 9108-9114 (1993b). 

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8. Biochemistry C.-S. Lee 33 6024 1994 10.1021/bi00185a043 Lee, C.-S., Pfeifer, G. P., and Gibson, N. W. Mapping of DNA alkylation sites induced by adozelesin and bizelesin in human cells by ligation-mediated polymerase chain reaction.Biochemistry, 33, 6024-6030 (1994). 

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9. Chem. Res. Toxicol. C.-S. Lee 4 203 1991 10.1021/tx00020a013 Lee, C.-S., Sun, D., Kizu, R., and Hurley, L. H. Determination of the structural feature of (+)-CC-1065 that are responsible for bending and winding of DNA.Chem. Res. Toxicol., 4, 203-213 (1991). 

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10. Nucleic Acids Res. W. B. Mattes 14 2971 1986 10.1093/nar/14.7.2971 Mattes, W. B., Hartley, J. A., and Kohn, K. W. DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.Nucleic Acids Res., 14, 2971-2987 (1986). 

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11. Methods Enzymol. A. Maxam 65 499 1980 10.1016/S0076-6879(80)65059-9 Maxam, A., and Gilbert, W. Sequencing end-labeled DNA with base-specific chemical cleavage.Methods Enzymol., 65, 499-560 (1980). 

    

12. J. Antibiot. J. P. McGovren 37 63 1984 10.7164/antibiotics.37.63 McGovren, J. P., Clarke, G. L., Pratt, E. A., & DeKoning, T. F. Preliminary toxicity studies with the DNA-binding antibiotic CC-1065.J. Antibiot., 37, 63-70 (1984). 

    

13. J. Am. Chem. Soc. M. A. Mitchell 113 8994 1991 10.1021/ja00023a085 Mitchell, M. A., Kelly, R. C., Winnienski, N. A., Hatzenbuhler, N. T., and Williams, M. G. Synthesis and DNA cross-linking by a rigid CPI dimer.J. Am. Chem. Soc., 113, 8994-8995 (1991). 

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14. Chem Res. Toxicol. M. A. Mitchell 6 421 1993 10.1021/tx00034a005 Mitchell, M. A., Weiland, K. L., Aristoff, P. A., Johnson, P. D., and Dooley, T. P. Sequence-selective guanine reactivity by duocarmycin A.Chem Res. Toxicol., 6, 421-424 (1993). 

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15. Biochemistry V. L. Reynolds 24 6228 1985 10.1021/bi00343a029 Reynolds, V. L., Molineux, I. J., Kaplan, D. H., and Hurley, L. H. Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity.Biochemistry, 24, 6228-6237 (1985). 

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16. Tetrahedron Lett. H. Sugiyama 34 2179 1993 10.1016/S0040-4039(00)60376-3 Sugiyama, H., Ohmori, K., Chan, K. L., Hosoda, M., Asai, A., Saito, H., and Saito, I. A novel guanine N 3 alkylation by antitumor antibiotic duocarmycin A.Tetrahedron Lett., 34, 2179-2182 (1993). 

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17. J. Am. Chem. Soc. D. Sun 115 5925 1993 10.1021/ja00067a005 Sun, D., and Hurley, L. H. Analysis of the monoalkylation and cross-linking sequence specificity of bizelesin, a bifunctional alkylation agent related to (+)-CC-1065.J. Am. Chem. Soc., 115, 5925-5933 (1993). 

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18. Chem. Res. Toxicol. D. Sun 6 889 1993 10.1021/tx00036a020 Sun, D., Park, H-J., and Hurley, L. H. Alkylation of guanine and cytosine in DNA by bizelesin. Evidence for a covalent immobilization leading to a proximity-driven alkylation of normally unreactive bases by a (+)-CC-1065 cross-linking compound.Chem. Res. Toxicol., 6, 889-894 (1993). 

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19. Biochemistry M. A. Warpehoski 31 2502 1992 10.1021/bi00124a009 Warpehoski, M. A., Harper, D. E., Mitchell, M. A., and Monroe, T. J. Reversibility of the covalent reaction of CC-1065 and analogs with DNA.Biochemistry, 31, 2502-2508 (1992). 

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