• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

흰쥐에서 Aminotriazole과 Diethyldithiocarbamate가 Paraquat의 독성에 미치는 영향

Effects of 3-Amino-1,2,4 Triazole and Diethyldithiocarbamate on Paraquat Toxicity in Rats


The effects of superoxide dismutase(SOD) and catalase on the toxicity of paraquat(PQ) were studied using diethyldithiocarbamate(DDC), 3-amino-1,2,4-triazole(AT) which are inhibitors of Cu, Zn-SOD and catalase in rats. Sprague Dawley rats were divide into 6 groups: control, DDC, PQ, AT, DDC+PQ, and AT+PQ group. The PQ (50 mg/kg body weight(BW); about half dose of $LD_{50}$) was administered with orally, otherwise AT(1.0g/kg BW) and DDC(1.0g/kg BW) were administered by intrperitoneal(iP) injection. The survival rate of rats in PQ+AT group was significantly decreased compared with PQ group while the difference of survival rate between DDC group and DDC+PQ group was not significant. The SOD activity after administration of DDC was decreased in liver, lung and kidney, but catalase activity was not changed. The catalase activity in liver, lung and kidney of AT treated rats was decreased, while SOD activity was not changed in this group. The effects of DDC and AT to the PQ toxicity was also observed in primary cultured rat Skin fibroblasts. The viable cells that was measured with MTT method, was decreased in AT+PQ treated group compared to PQ treated group, but the difference of cell viability between DDC treat group and DDC+PQ treated group was not observed. This result, AT potentlate PQ toxicity while DDC were not affect, suggested that the decreased catalase activity lead to elevation of hydrogen peroxide levels and PQ toxicity may be correlate with the hydrogen peroxide rather than the superoxides.

저자의 다른 논문

참고문헌 (25)

  1. Aebi, H.;Bergmeyer, H.U.(ed.);Bergmeyer, J.(ed.);GralBl, M.(ed.) , Catalase, Methods of Enzymatic analysis / v.3,pp.273-286, 1983
  2. Superoxide and singlet oxygen-catalyed lipid peroxidation as a possible mechanism for paraquat (methy viologen) toxicity , Bus, J.S.;Aust, S.D.;Gibson, J.E. , Biochem. Biophys. Res. Comman. / v.58,pp.749-755, 1974
  3. Evaluation of a tetrazolium-based semiautomated colorimetric assay : assessment of chemosensitivity testing , Carmichael, J.W.;Degraff, W.G.;Gazdar, A.F.;Minna, J.D.;Michell, J.B. , Cancer Res. / v.47,pp.936-942, 1987
  4. Preparation and assay of superoxide dismutase , Crapo, J.D.;McCord, J.M.;Fridovich, I.;Fleischer, S.(ed.);Packer, L.(ed.) , Methods in Enzymology / v.53,pp.382-393, 1978
  5. Catalase physical and chemical properties mechanism of catalysis and physiological role , Deisseroth, A.;Dounce, A.L. , Physiol. Rev. / v.50,pp.319-375, 1970
  6. Compounds I of catalase horseradish peroxidase , Dolphin, D.;Forman, A.;Berg, D.C.;Fajce, J.;Felton, R.H. , Proc. Natl. Acad. Sci. USA / v.68,pp.614-618, 1971
  7. Disaggregation of the tissue and Primary culture , Freshney, R.I. , Culture of animal cells / v.,pp.104-118, 1983
  8. Superoxide dxmutase , Fridovich, I. , Annu. Rev. Biochem. / v.44,pp.147-159, 1975
  9. Superoxide dismutase , Fridovich, I. , J. Biol. chem. / v.264,pp.7761-7764, 1989
  10. In vivo generation of hydrogen peroxide by rat kidney cortex and glomeruli , Guidet, B.R.;Shah, S.V. , Am. J. Physiol. / v.256,pp.158-164, 1989
  11. Enhanced In vivo H₂O₂ generation by rat kidney in glycerol induced renal failure , Guidet, B.R.;Shah, S.V. , Am. Physiol. / v.257,pp.440-445, 1989
  12. Rales of free radicals and caralytic metalinos in human disease , Halliwell, B.;Gutterridge, J.M.C. , Methods in Enzymology / v.186,pp.1-85, 1990
  13. Superoxide radical and oxygen enhancemen of the toxicity of paraquat in escherica coli , Hassan, H.M.;Fridovich, I. , J. Biol. Chem. / v.253,pp.8143-8148, 1978
  14. Metabolism of hydrogen peroxide in isolated hepatocytes : relative contributions of catalase and glutathione peroxidase in decomposition of endogenously generated H₂O₂ , Jones, D.P.;Eklow, L.;Thor, H.;Orrenius, S. , Arch. Biochem. Biophys. / v.210,pp.505-516, 1981
  15. Inhibition of erythrocyte superoxide by diethyldithiocarbamate also results in oxyhemoglobin-catalyzed glutathione depletion and methemoglobin production , Kelner, M.J.;Alexander, N.M. , J. Biol. Chem. / v.261,pp.1636-1642, 1986
  16. Alteration of endogenous glutathione peroxidase, manganese superoxide dismutase expression vector. Explanation for variations in paraquat resistance , Kelner, M.J.;Bagnell, R. , J. Biol. chem. / v.265,pp.10872-10875, 1990
  17. The effect of paraquat on microsomal lipid peroxidation in vitro and in vivo , Kornbrust, D.J.;Mavis, R.D. , Toxicol. Appl. Pharmacol. / v.53,pp.323-332, 1982
  18. Protein measurement with folin phenol reagent , Lowry, C.H.;Rosebrough, N.J.;Farr, A.L.;Radall, R.J. , J. Biol. Chem. / v.193,pp.256-277, 1951
  19. Glutathione , Meister, A.;anderson, M.E. , Ann. Rev. Biochem. / v.52,pp.711-760, 1983
  20. Oberley, L.W.(ed.) , Superoxide dismutase and cancer, superoxide dismutse / v.,pp.127-165, 1982
  21. Null mutation of copper/Zinc superoxide dismutase in drosophila cofers hypersensitivity to paraquat and radical longevity , Phillips, J.P.;Campbell, S.D.;Michard, D.;Charbonneau, M.;Hilliker, A.J. , Proc. Natl. Acad. Sci. / v.86,pp.2761-2765, 1989
  22. Proctor, P.H.;Miguel, J.(ed.);Quintanilha, A.T.(ed.);Weber, H.(ed.) , Free radical and human disease, in CRC handbook of free radical and antioxidants in biomedicine / v.1,pp.209-222, 1989
  23. Overexpression of Cu-Zn superoxide dismutase in Drosophila does not affect life-span , Seto, N.O.;Hayashi, S.;Tener, G.M. , Proc. Natl. Acad. Sci. / v.87,pp.4270-4274, 1990
  24. Overproduction of human Mn-Superoxide modulates paraquat mediated toxicity in mammalian cells , StClair, D.K.;Oberley, T.D.;Ho, Y.S. , FEBS Lett. / v.293,pp.199-203, 1991
  25. 일차배양 백서 피부섬유아세포에서 paraquat독성에 미치는 SOD와 catalase의 영향 , 차종희;유의경 , 대한화학회지 / v.38,pp.74-79, 1994

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음


원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일