• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

지방산 결합단백질과 인지질막 사이의 지방산이동기전

Mechanism of Fatty Acid Transfer between Fatty Acid Binding Proteins and Phospolipid Model Membranes


Fatty acid binging proteins(FABP) are distinct but related gene productes which are found in many mamalian cell types. FABP bind long chain fatty acids in vitro. However, their functions and mechanisms of action, in vivo, remain unknown . Also not known is whether all FABP function similaryly in their respective cell types. or whether different FABP have unique functions. The puropose of the present study was to assess whether different members of the FABP family exhibit different structural and function properties. A comparison was made between heart(H-FABP) and liver (L-FABP). The results show that the binding sites of both FABP are hydrophobic in nature, although the L-FABP site is more nonpolar than the H-FABP site. Additionally, the bound ligand experiences less motional constraint within the H-FABP binding site than within the L-FABP binding site. In accordance with these differences in structural properties, it was found that anthroyloxy-fatty acid transfer from H-FABP to membranes is markedly faster than from L-FABP. moreover, the mechanism of fatty acid transfer to phospholipid membranes appears to occur via transient collisional interactions between H-FABP and membranes. In contrast , transfer of fatty acid from L-FABP occurs via an aqueous diffusion mechanism.

저자의 다른 논문

참고문헌 (30)

  1. Fatty acid binding sites of rodent adipocyte and heart fatty acid binding proteins , Wootan,M.G.;Bass,N.M.;Bernlohr,D.A.;Storch,J. , Biochem / v.29,pp.9305-9311, 1990
  2. Fatty acid binding protein from rat heart , Said,B.;Schulz,H. , J Biol Chem / v.259,pp.1155-1159, 1984
  3. Preparation of homogenous, singl-walled phosphatidylcholine vesicles , Huang,C.;Thompson,T.E. , Methods Engymol / v.32,pp.212-235, 1974
  4. The cellular fatty acid binding proteins : Aspects of structure, regulation and function , Bass,N.M. , Int Rev Cytol / v.111,pp.143-184, 1988
  5. Transfer of long chain fluorescent free fatty acids between unilamellar vesicles , Storch,J.;Kleinfeld,A.M. , Biochem / v.25,pp.1717-1726, 1986
  6. Cleavage of structural proteins during the assembly of the head of Bacteriophage T4 , Laemmli,U.K. , Nature / v.227,pp.680-685, 1970
  7. A binding protein for fatty acids in cytosel of intestinal mucosa , Ockner,R.K.;Manning,J.A.;Poppen hausen,R.D.;Ho,W.K.L. , Science / v.177,pp.56-58, 1972
  8. Cellular lipid binding proteins : expression, function, and nutritional regulation , Scott,T.G.;Spencer,R.D.;Leonard,N.J.;Weber,G. , J Am Chem Soc / v.92,pp.687-695, 1970
  9. Tissue expression of three structurally different fatty acid binding proteins from rat heart muscle, liver and intestine , Bass,N.M.;Manning,J.A. , Biochem Biophys Res Commun / v.137,pp.929-935, 1986
  10. Campbell,I.D.;Dwek,R.A. , Biological Spectroscopy / v.,pp.91-121, 1984
  11. Fatty acid binding protein, isolation from rat liver, characterization, and immunochemical quantification , Ockner,R.K.;Manning,J.A.;Kane,J.P. , J Biol Chem / v.257,pp.7872-7878, 1982
  12. Lipid exchange, Transmembrane movement, spantaneous movement, and protein-mediated transfer of lipids and cholesterol , Dawidowicz,E.A. , Curr Topics Membr Transp / v.29,pp.175-202, 1987
  13. Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions , Levi,A.J.;Gatmaitan,Z.;Arias,I.M. , J Clin Invest / v.48,pp.2156-2167, 1969
  14. Characterization of a fatty acid binding protein from rat heart , Offner,G.D.;Troxler,R.F.;Brecher,P. , J Biol Chem / v.261,pp.5584-5589, 1986
  15. Modification of the colorimetric phosphorous determination for use with the photo-electric colorimeter , Gomori,G.A. , J Lab Clin Med / v.27,pp.955-960, 1942
  16. Isolation and characterization of the fractions(DE-Ⅰ, DE-Ⅱ and DE-Ⅲ) of rat liver Z protein and the complete primary structure of DE-Ⅱ , Takahash,K.;Odani,S.;Ono,T. , Eur J Biochem / v.136,pp.589-601, 1983
  17. Glatz,J.F.C.;van Bilsen,M.;Paulussen,R.J.A.;Veerkamp,J.H.;vander Vusse,G.J.;Reneman,R.S. , Biochim Biophys Acta / v.961,pp.148-152, 1988
  18. Fatty acid binding protein in small intestine, identification, isolation, and evidence for its role in cellular fatty acid transport , Ockner,P.K.;Manning,J.A. , J Clin Invest / v.54,pp.326-338, 1974
  19. Rat heart fatty acid binding protein is highly homologous to the murine adipocyte 422 protein and the P2 protein of peripheral nerve myelin , Sacchettini,J.C.;Said,B.;Schulz,H.;Gordon,J.I. , J Biol Chem / v.261,pp.8218-8223, 1986
  20. Transfer of fluorescent fatty acids from liver and heart fatty acid binding proteins to model membranes , Storch,J.;Bass,N.M. , J Bio Chem / v.265,pp.2827-2831, 1990
  21. Expression cloning and characterization of a adipocyte long chain fatty acid transport protein , Schaffer,J.E.;Lodish,H.F. , Cell / v.79,pp.427-436, 1994
  22. Lakowicz,J.R. , Principles of Fluorescence Spectroscopy / v.,pp.257-274, 1983
  23. The nucleotide sequence of rat liver fatty acid-binding protein mRNA , Gordon,J.I.;Alpers,D.H.;Ockner,R.K.;Strauss,A.W. , J Biol Chem / v.258,pp.3356-3363, 1983
  24. Intracellular fatty acid binding proteins , Glatz,J.F.C.;Veerkamp,J.H. , Int J Biochem / v.17,pp.13-22, 1985
  25. Spontaneous lipid transfer between organized lipid assemblies , Brown,R.E. , Biochem Biophys Acta / v.1113,pp.375-389, 1992
  26. The binding of fatty acids to cytoplasmic proteins : binding to Z-protein in liver and other tissues of the rat , Mishkin,S.;Stein,L.;Gatmaitan,Z.;Arias,I.M. , Biochem Biophys Res Commun / v.47,pp.997-1003, 1992
  27. Detection, tissue distribution and sub cellular localization of fatty acid binding protein types , Veerkamp,J.H.;Paulussen,R.J.A.;Peeters,R.A.;Maatman,R.G.H.J.;van Moerke,H.T.B.;van Kuppevelt,J.H.M.S.M. , Mol Cell Biochem / v.98,pp.11-18, 1990
  28. Effect of salts on activity coefficients , Long,F.A.;McDevit,W.F. , Chem Rev / v.51,pp.119-169, 1952
  29. Transfer of long chain fluorescent free fatty acids between small and large unilamellar vesicles , Storch,J.;Kleinfeld,A.M. , Biochem / v.32,pp.2053-2061, 1993
  30. Protein measurement with the Folin Phenol reagent , Lowry,O.H.;Rosebrough,N.J.;Farr,A.L.;Randall,R.J. , J Biol Chem / v.193,pp.265-275, 1951

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음


원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일