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Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.25 no.2, 2002년, pp.111 - 136
Lee, Henry-J. (College of Pharmacy and Pharmaceutical Science, Florida A＆M University. Tallahassee, 32307, Florida, USA) , Cooperwood, John-S. (College of Pharmacy and Pharmaceutical Science, Florida A＆M University. Tallahassee, 32307, Florida, USA) , You, Zhengqing (College of Pharmacy and Pharmaceutical Science, Florida A＆M University. Tallahassee, 32307, Florida, USA) , Ko, Dong-Hoon (College of Pharmacy and Pharmaceutical Science, Florida A＆M University. Tallahassee, 32307, Florida, USA)
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The prodrug and antedrug concepts, which were developed to overcome the physical and pharmacological shortcomings of various therapeutic classes of agents, employ diametrically different metabolic transformations. The prodrug undergoes a predictable metabolic activation prior to exhibiting its pharm...
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