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Cotinine Inhibits Catecholamine Release Evoked by Cholinergic Stimulation from the Rat Adrenal Medulla 원문보기

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.26 no.9, 2003년, pp.747 - 755  

Koh, Young-Yeop (Department of Internal Medicine (Cardiology), College of Medicine, Chosun University) ,  Jang, Seok-Jeong (Department of Neurosurgery (Cerebrovascular Surgery), College of Medicine, Chosun University) ,  Lim, Dong-Yoon (Department of Pharmacology, College of Medicine, Chosun University)

Abstract AI-Helper 아이콘AI-Helper

The aim of the present study was to clarify whether cotinine affects the release of catecholamines (CA) from the isolated perfused rat adrenal gland, and to establish the mechanism of its action, in comparison with the response of nicotine. Cotinine (0.3∼3 mM), when perfused into an adrenal vein for...

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제안 방법

  • There is a big controversy in the pharmacological actions of cotinine so far. Therefore, the present study was designed to clarify whether cotinine affects the release of catecholamines (CA) evoked by cholinergic stimulation and the membranedepolarization 1rom the perfused rat adrenal gland and to elucidate the mechanism of action, in comparison with the response of nicotine.

이론/모형

  • CA content of perf니sate was measured directly by the fluorcimetric method of Anton and Sayre (1962) without the intennediate purification alumina for the reasons described earlier ;Wakade, 1981) using fluorospectrophotometer (Koniron Co. Italy).
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