[논문]Effects of NMDA, AMPA and Kainate on the Release of Acetylcholine in Rat Hippocampal and Striatal Slices

Kim, Do Kyung; Lee, Se-Oul; Jung, Kyu-Yong; Kim, Jong-Keun; Choi, Bong-Kyu

Effects of NMDA, AMPA and Kainate on the Release of Acetylcholine in Rat Hippocampal and Striatal Slices 원문보기

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, v.8 no.6, 2004년, pp.301 - 305

Kim, Do Kyung (Department of Oral Physiology, Chosun University College of Dentistry) , Lee, Se-Oul (Department of Pharmacology, Wonkwang University School of Medicine) , Jung, Kyu-Yong (Department of Pharmacology, Wonkwang University School of Medicine) , Kim, Jong-Keun (Deportment of Pharmacology, Chonnam National University Medical School, Chonnum National University Research Institute of Medical Sciences) , Choi, Bong-Kyu (Department of Pharmacology, Wonkwang University School of Medicine)

Abstract ▼ AI-Helper

This study examined the effects of N-methyl-D-aspartate (NMDA), ${\alpha}-amino$-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate on basal and electrically-evoked release of acetylcholine (ACh) from the rat hippocampal and striatal slices which were preincubated with $[^3H]choline$. Unexpectedly, the basal and evoked ACh release were not affected at all by the treatment with NMDA $(3{\sim}100{\mu}M)$, AMPA $(1{\sim}100{\mu}M)$ or kainate $(1{\sim}100{\mu}M)$ in hippocampal slices. However, in striatal slices, under the $Mg^{2+}-free$ medium, $30{\mu}M$ NMDA increased the basal ACh release with significant decrease of the electrically-evoked releases. The treatment with $1{\mu}M MK-801 not only reversed the $30{\mu}M$ NMDA-induced decrease of the evoked ACh release, but also attenuated the facilitatory effect of $30\;{\mu}M$ NMDA on the basal ACh release. The treatment with either $30\;{\mu}M$ AMPA or $100\;{\mu}M$ kainate increased the basal ACh release without any effects on the evoked release. The treatment with $10{\mu}M$ NBQX abolished the AMPA- or kainate-induced increase of the basal ACh release. Interestingly, NBQX significantly attenuated the evoked release when it was treated with AMPA, although it did not affect the evoked release alone without AMPA. These observations demonstrate that in hippocampal slices, ionotropic glutamate receptors do not modulate the ACh release in cholinergic terminals, whereas in striatal slices, activations of ionotropic glutamate receptors increase the basal ACh release though NMDA may decrease the electrically-evoked ACh release.

주제어

참고문헌 (25)

Arruda Paes PC, de Magalhaes L, Camillo MA, Rogero JR, Troncone LR. Ionotropic glutamate receptors regulating labeled acetylcholine release from rat striatal tissue in vitro: possible involvement of receptor modulation in magnesium sensitivity. Neurosci Res 49: 289－295, 2004

상세보기
Badini I, Beani L, Bianchi C, Marzola G, Siniscalchi A. Postischemic recovery of acetylcholine release in vitro: influence of different excitatory amino acid receptor subtype antagonists. Neurochem Int 31: 817－824, 1997

상세보기
Cotman CW, Foster A, Lanthorn T. An overview of glutamate as a neurotransmitter. Adv Biochem Psychopharmacol 27: 1－27, 1981
Gasic GP, Hollmann M. Molecular neurobiology of glutamate receptors. Annu Rev Physiol 54: 507－536, 1992

상세보기
Giovannini MG, Rakovska A, Della Corte L, Bianchi L, Pepeu G. Activation of non-NMDA receptors stimulates acetylcholine and GABA release from dorsal hippocampus: a microdialysis study in the rat. Neurosci Lett 243: 152－156, 1998

상세보기
Hadjiivanova C, Petkov VD, Maslarov D, Totev A, Panova Y, Belcheva I. Effect of dotarizine on K(+)-stimulated $[^3H]$ - serotonin and $[^3H]$ -acetylcholine release from rat. hippocampus. Gen Pharmacol 28: 129－132, 1997
Hertting G, Zumstein A, Jackisch R, Hoffmamn I, Starke K. Modulation of endogeneous release of dopamine and acetylcholine in the caudate neucleus of the rabbit. Naunyn-Schmiedeberg's Arch Pharmacol 315: 111－117, 1980

상세보기
Hortnagl H, Berger ML, Sperk G, Pifl C. Regional heterogeneity in the distribution of neurotransmitter markers in the rat hippocampus. Neuroscience 45: 261－272, 1991

상세보기
Jin S, Fredholm BB. Electrically-evoked dopamine and acetylcholine release from rat striatal slices perfused without magnesium: regulation by glutamate acting on NMDA receptors. Br J Pharmacol 121: 1269－1276, 1997

상세보기
Jin S, Fredholm BB. Role of NMDA, AMPA and kainate receptors in mediating glutamate- and 4-AP-induced dopamine and acetylcholine release from rat striatal slices. Neuropharmacology 33: 1039－1048, 1994

상세보기
Lehmann J, Scatton B. Characterization of the excitatory amino acid receptor-mediated release of $[^3H]$ acetylcholine from rat striatal slices. Brain Res 252: 77－89, 1982

상세보기
Leslie FM, Gallardo KA, Park MK. Nicotinic acetylcholine receptormediated release of [(3)H]norepinephrine from developing and adult rat hippocampus: direct and indirect mechanisms. Neuropharmacology 42: 653－661, 2002

상세보기
Lewis PR, Shute CC, Silver A. Confirmation from choline acetylase analyses of a massive cholinergic innervation to the rat hippocampus. J Physiol 19: 215－224, 1967
Marti M, Sbrenna S, Fuxe K, Bianchi C, Beani L, Morari M. In vitro evidence for increased facilitation of striatal acetylcholine release via pre- and postsynaptic nmda receptotors in hemiparkinsonian rats. J Neurochem 72: 875－878, 1999

상세보기
Milusheva E, Baranyi M, Zelles T, Mike A, Vizi ES. Release of acetylcholine and noradrenaline from the cholinergic and adrenergic afferents in rat hippocampal CA1, CA3 and dentate gyrus regions. Eur J Neurosci 6: 187－192, 1994

상세보기
Monnet FP, Mahe V, Robel P, Baulieu EE. Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus. Proc Natl Acad Sci U S A 92: 3774－3778, 1995.

상세보기
Morari M, Sbrenna S, Marti M, Caliari F, Bianchi C, Beani L. NMDA and non-NMDA ionotropic glutamate receptors modulate striatal acetylcholine release via pre- and postsynaptic me chanisms. J Neurochem 71: 2006－2017, 1998

상세보기
Nankai M, Fage D, Carter C. Striatal NMDA receptor subtypes: the pharmacology ofN-methyl-D-aspartate-evoked dopamine, gamma-aminobutyric acid, acetylcholine and spermidine release. Eur J Pharmacol 286: 61－70, 1995

상세보기
Pittaluga A, Raiteri M. N-Methyl-D-aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. I. Location on axon terminals and pharmacological characterization. J Pharmacol Exp Ther 260: 232－237, 1992a

상세보기
Pittaluga A, Raiteri M. N-Methyl-D-Aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. Ⅲ. changes in the NMDA receptor complex induced by their functional cooperation. J Pharmacol Exp Ther 263: 327－ 333, 1992b

상세보기
Reiteri M, Garrone B, Pittaluga A. N-Methyl-D-Aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. II. Evidence for functional cooperation and for coexistence on the same axon terminal. J Pharmacol Exp Ther 260: 238－242, 1992

상세보기
Rosi S, Giovannini MG, Lestage PJ, Munoz C, Corte LD, Pepeu G. S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat. Neurosci Lett 361: 120－123, 2004

상세보기
Ruzicka BB, Jhamandas KH. Excitatory amino acid action on the release of brain neurotransmitters and neuromodulators: biochemical studies. Prog Neurobiol 40: 223－247, 1993

상세보기
Ulus IH, Buyukuysal RL, Wurtman RJ. N-methyl-D-aspartate increases acetylcholine release from rat striatum and cortex: Effect is augmented by choline. J Pharmacol Exp Ther 261: 1122－ 1128, 1992
Zorumski CF, Thio LL. Properties of vertebrate glutamate receptors: calcium mobilization and desensitization. Prog Neurobiol 39: 295－336, 1992

상세보기

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Effects of NMDA, AMPA and Kainate on the Release of Acetylcholine in Rat Hippocampal and Striatal Slices 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (25)

이 논문을 인용한 문헌

저자의 다른 논문 :

관련 콘텐츠

원문 보기

원문 URL 링크

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

Effects of NMDA, AMPA and Kainate on the Release of Acetylcholine in Rat Hippocampal and Striatal Slices 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (25)

이 논문을 인용한 문헌

저자의 다른 논문 :

김도경 (39) Lee, Seoul (10) 정규용 (25) 김종근 (14) 최봉규 (25)

관련 콘텐츠

원문 보기

원문 URL 링크

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트