[논문]Cell Cycle Regulation and Antioxidant Activity of Psammaplin A, A Natural Phenolic Compound from Marine Sponge

Jiang, Ya-Hong; Ryu, Seung-Hee; Ahn, Eun-Young; You, Song; Lee, Burm-Jong; Jung, Jee-H; Kim, Dong-Kyoo

Cell Cycle Regulation and Antioxidant Activity of Psammaplin A, A Natural Phenolic Compound from Marine Sponge 원문보기

Natural product sciences, v.10 no.6, 2004년, pp.277 - 283

Jiang, Ya-Hong (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University) , Ryu, Seung-Hee (Department of Chemistry and Biohealth Products Research Center, Inje University) , Ahn, Eun-Young (Department of Chemistry and Biohealth Products Research Center, Inje University) , You, Song (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University) , Lee, Burm-Jong (Department of Chemistry and Biohealth Products Research Center, Inje University) , Jung, Jee-H (College of Pharmacy, Pusan National University) , Kim, Dong-Kyoo (Department of Chemistry and Biohealth Products Research Center, Inje University)

Abstract ▼ AI-Helper

Psammaplin A (PSA), a naturally occurring biophenolic compound has been demonstrated to deliver significant cytotoxicity to many cancer cell lines. In this article, we investigated the effect of PSA on cell cycle progression of lung cancer cells (A549). It was found that PSA could slightly perturb the cell cycle progression of A549 cells and lead to the cell cycle arrest at G2/M phase, indicating PSA might disturb the mitosis process of A549 cells. In addition, inspired by the two phenolic groups in the structure of PSA, the antioxidant activity of it has been evaluated. Although PSA was weak in scavenging the stable free radical 1,1-diphenyl-2-picrylhyrazyl (DPPH), it showed stronger ABTS radical scavenging activity than ascorbic acid in TEAC assay. Furthermore, it was found that PSA could effectively prevent DNA strand scission induced by oxidative stress. These results suggest that PSA have both cell cycle regulation and antioxidant activities. Herein, we suggest that PSA would be a very interesting and promising candidate to be developed as a multi-function drug.

주제어

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가설 설정

Therefore, there is an urgent need for more potent drugs and new strategies aimed to improve lung cancer management. In this article, we invested whether PSA affected the cell cycle distribution of human lung cancer A549 cells. When A549 cells were treated with various concentrations of PSA for 48 hr, PSA inhibited the cell viability dose dependently (Fig.

이론/모형

Measurement of Trolox equivalent antioxidant capacity (TEAC) - The Trolox equivalent antioxidant capacity of the PSA was determined by the method of Re et al. (1999). Ascorbic acid was used as an antioxidant reference.

후속연구

It is not clear now whether the antioxidant activity contributes to its anticancer effect because of lacking definite evidence. In order to clarify this question, further studies should be carried out. However, this is first report about the antioxidant activity of PSA, which gives some new information about this unique compound.

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