$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Evaluation of clinical usefulness of reference interval of some selected hematological parameters in canine blood 원문보기

大韓獸醫學會誌 = Korean journal of veterinary research, v.44 no.4 = no.117, 2004년, pp.649 - 653  

Pak, Son-Il (paksi@kangwon.ac.kr) ,  Han, Ho-Jae

Abstract ▼ AI-Helper 아이콘AI-Helper

To estimate the source of variance components for some hematological parameters and assess the utility of the conventional population-based reference interval, this study computed index of individuality for blood samples, which were from 13 dogs drawn once weekly for 4 consecutive weeks. Results wer...

주제어

#index of individuality   #reference interval   #hematology   #variability   #dog  

AI 본문요약
AI-Helper 아이콘 AI-Helper

* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.

제안 방법

  • In this study, for the parameters Hb, RDW, manual HCT and MPV with relatively intermediate coefficient (range 0.63-0.69), a single measurement will moderately classify the participants with respect to his or her short-term average analyte concentration. Except for MCV (R=0.
  • The indexes of individuality are also included as percentages of total variances, along with the CVs. The analytes in order of the increasing reliability coefficient and the decreasing index of individuality were as follows: MCHC, RBC, monocyte count, WBC, neutrophil count, lymphocyte count, platelet count, HCT, Hb, MPV, manual HCT, RDW, and MCV. Weekly differences for all analytes in the same dogs were not statistically significant although some variation between dogs was noted.

대상 데이터

  • Thirteen adult mixed-breed dogs, 4 males and 9 females, with an age range of 2 to 5 years, weighing 4-15 kg were included in the study. The dogs were housed at the animal hospital and used for student training and blood donors.

데이터처리

  • comparison. The variance component analysis was performed using PROC NESTED procedure of the Statistical Analysis System Version 8.1 (SAS, Cary, NC), and if negative variance components resulted, values of zero were used. A value of P<0.
  • Weekly differences in the same dog were assessed using the nonparametric Friedman ANOVA test, with dogs serving as blocking factors, followed by Duncan’s multiple comparison. The variance component analysis was performed using PROC NESTED procedure of the Statistical Analysis System Version 8.

이론/모형

  • For a statistical analysis, a nested random effects analysis of variance model (ANOVA) was used, assuming a standard constant variance; i.e., both within-person and analytical variances were constant at any level of the parameter [6]. With this model, the total variance (S2total) can be break down into three components - between-dog variance (S2inter), within-dog variance (S2intra), and analytical variance (S2analy) - and calculate as follows: S2total = S2inter +, S2intra + Sealy [1, 13-15].
본문요약 정보가 도움이 되었나요?

참고문헌 (16)

  1. Chambless, L. E., McMahon, R., Wu, K., Folsom, A., Finch, A. and Shen, Y. L. Short-term intraindividual variability in hemostasis factors: the ARIC study. Ann.Epidemiol. 1992, 2, 723-733 

  2. Eckfeldt, J. H., Chambless, L. E. and Shen, Y. Shortterm, within-person variability in clinical chemistry results: experience from the atherosclerosis risk in communities study. Arch. Pathol. Lab. Med. 1994, 118, 496-500 

  3. Fraser, C. G. and Harris, E. K. Generation and application of data on biological variation in clinical chemistry. Crit. Rev. Clin. Lab. Sci. 1989, 27, 409-437 

  4. Fraser, C. G. and Hearne, C. R. Components of variance of some plasma constituents in patients with myocardial infarction. Ann. Clin. Biochem. 1982, 19,431-434 

  5. Garg, U. C., Zheng, Z. J., Folsom, A. R., Moyer, Y. S., Tsai, M. Y., McGovern, P. and Eckfeldt, J. H. Short-term and long-term variability of plasma homocysteine measurement. Clin. Chem. 1997, 43, 141-145 

  6. Graybill, F. A. and Wang, C. M. Confidence intervals for proportions of variability in two-factor nested variance component models. J.Am. Stat. Assoc. 1979, 74, 368-374 

  7. Harris, E. K. Effects of intra- and interindividual variation on the appropriate use of normal ranges. Clin. Chem. 1974, 20, 1535-1542 

  8. H $\"{o}$ lzel, W. G. E. Intra-individual variation of some analytes in serum from patients with insulin-dependent diabetes mellitus. Clin. Chem. 1987, 33, 57-61 

  9. Jensen, A. L., Houe, H. and Nielsen, C. G. Critical differences of clinical-chemical parameters in blood from Red Danish dairy cows. Res. Vet. Sci. 1992, 52, 86-89 

  10. Jensen, A. L. Critical differences of clinical chemical parameters in blood from dogs. Res. Vet. Sci. 1993, 54, 10-14 

  11. Jensen, A. L., Koch, J. and Wenck, A. Estimates of components of variance of the rectal temperature in clinically healthy dogs in a hospital environment. J. Vet.Med. A. 1994, 41, 717-721 

  12. Marca, M. C. and Loste, A. Glycosylated haemoglobin in dogs: study of critical difference value. Res. Vet. Sci. 2001, 71, 115-117 

  13. Queralto, J. M., Boyd, J. C. and Harris, E. K. On the calculation of reference change values, with examples from a long-term study. Clin. Chem. 1993, 39, 1398-1403 

  14. Pascoe, P. J., Gallagher, C. S. and Fraser, C. G. Components of biological variation of some serum analytes in hospitalized pregnant women. Clin. Chem.1984, 30, 583-584 

  15. Ross, J. W. Evaluation of precision. In: Werner M, ed. Handbook of clinical chemistry. pp. 391-422. CRC Press, Boca Raton, 1982 

  16. Snedecor, G. W. and Cochrane, W. G. Statistical methods. pp. 379-384. 7th ed. Iowa State University Press, Ames, 1980 

저자의 다른 논문 :

관련 콘텐츠

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로