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논문 상세정보

Synthesis and Biological Activity of Benzoxazole Containing Thiazolidinedione Derivatives

Abstract

The peroxisome proliferator-activated receptors (PPARs) are a primary regulator of lipid metabolism. Potency for activation of PPAR$\gamma$, one of a subfamily of PPARs, particularly mirrors glucose lowering activity. We prepared thiazolidinediones featuring benzoxazole moiety for subtype selective PPAR$\gamma$ activators. 5-[4-[2-(Benzoxazol-2-yl-alkylamino)ethoxy]benzyl]thiazolidine-2,4-diones have been prepared by Mitsunobu reaction of benzoxazolylalkylaminoethanol 8 and hydroxybenzylthiazolidinedione 6 and their activities were evaluated. Most compounds tested were identified as potent PPAR$\gamma$ agonists.

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이 논문을 인용한 문헌 (1)

  1. Kang, Young-Soon ; Han, Min Ho ; Lee, Moon Hee ; Hong, Su Hyun ; Park, Heungsik ; Jung, Jae-Chul ; Lee, Jeongrai ; Lee, Eun-Woo ; Kang, Kyung Hwa ; Kim, Cheol Min ; Kim, Byung-Woo ; Choi, Yung Hyun 2013. "Fructus Sophorae Enhances the Production of Prostaglandin E2 and Tumor Necrosis Factor-α through Activation of MAPKs and PI3K/AKT Signaling Pathways in Murine Macrophages" 생명과학회지 = Journal of life science, 23(11): 1397~1403 

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