• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보


The effects of four tanshinones isolated from Tanshen (the root of Salvia miltiorrhiza Bunge, Labiatae) were tested for their inhibition of nitric oxide production in macrophage cells, and the underlying molecular mechanisms studied. Of the four tanshinones used, 15, 16-dihydrotanshinone- I, tanshinone-IIA and cryptotanshinone, but not tanshinone I, demonstrated significant inhibition of the LPS-induced nitric oxide production in RAW 264.7 cells, with calculated $IC_{50}$ values of 5, 8, and 1.5 ${\mu}M$ , respectively. Tanshinones exerted inhibitory activities on the LPS-induced nitric oxide production only when applied concurrently with LPS, and tanshinone- IIA and cryptotanshinone were found to inhibit LPS-induced NF-$_KB$ mobilization and extracellular- regulated kinase (ERK) activation, respectively. These results suggest that tanshinones inhibit LPS-induced nitric oxide generation by interfering with the initial stage of LPS-induced expression of certain genes. NF-$_KB$ and ERK could be the molecular targets for tanshinones for the inhibition of LPS-induced nitric oxide production in macrophage cells.

참고문헌 (21)

  1. Chen, C., Chen, Y. H., and Lin, W. W., Involvement of p38 mitogen-activated protein kinase in Iipopolysaccharide- induced iNOS and COX-2 expression in J774 macrophages. Immunology, 97, 124-129 (1999) 
  2. Chen, C. C. and Wang, J. K., p38 but not p44/42 mitogenactivated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages. Mol. Pharmacal., 55, 481-488 (1999) 
  3. Cho, D. I., Koo, N. Y., Chung, W J., Kim, T. S., Ryu, S. Y., 1m, S. Y., and Kim, K. M., Effects of resveratrol-related hydroxystilbenes on the nitric oxide production in macrophage cells: structural requirements and mechanism of action. Life Sci., 71, 2071-2082 (2002) 
  4. Choi, H. S. and Kim, K. M., Tanshinones inhibit mast cell degranulation by interfering with IgE receptor-mediated tyrosine phosphorylation of PLCgamma2 and MAPK. Planta Med., 70, 178-180 (2004) 
  5. Furchgott, R. F. and Zawadzki, J. V., The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288, 373-376 (1980) 
  6. Jaramillo, M., Gowda, D. C., Radzioch, D., and Olivier, M., Hemozoin increases IFN-gamma-inducible macrophage nitric oxide generation through extracellular signal-regulated kinase- and NF-kappa B-dependent pathways. J. Immunol., 171, 4243-4253 (2003) 
  7. Kang, B. Y., Chung, S. W., Kim, S. H., Ryu, S. Y., and Kim, T. S., Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza. Immunopharmacology 49, 355-361 (2000) 
  8. Kim, J. Y., Kim, K. M., Nan, J. X., Zhao, Y. Z.. Park, P. H., Lee, S. J., and Sohn, D. H., Induction of apoptosis by tanshinone I via cytochrome c release in activated hepatic stellate cells. Pharmacol. Toxicol., 92, 195-200 (2003) 
  9. Wei, X. Q., Charles, I. G., Smith, A., Ure, J., Feng, G. J., Huang, F. P., Xu, D., Muller, W, Moncada, S., and Liew, F. Y, Altered immune responses in mice lacking inducible nitric oxide synthase. Nature, 375, 408-411 (1995) 
  10. Bethea, J. R., Ohmori, Y., and Hamilton, T. A., A tandem GC box motif is necessary for lipopolysaccharide-induced transcription of the type II TNF receptor gene. J. Immunol., 158, 5815-5823 (1997) 
  11. Kim, H. H., Kim, J. H., Kwak, H. B., Huang, H., Han, S. H., Ha, H., Lee, S. W, Woo, E. R., and Lee, Z. H., Inhibition of osteoclast differentiation and bone resorption by tanshinone IIA isolated from Salvia miltiorrhiza Bunge. Biochem. Pharmacol., 67, 1647-1656 (2004) 
  12. Ryu, S. Y., Lee, C. O., and Choi, S. U., In vitro cytotoxicity of tanshinones from Salvia miltiorrhiza. Planta Med., 63, 339-342 (1997) 
  13. Seol, I. W., Kuo, N. Y., and Kim, K. M., Effects of dopaminergic drugs on the mast cell degranulation and nitric oxide generation in RAW 264.7 cells. Arch. Pharm. Res., 27, 94-98 (2004) 
  14. Walker, G., Pfeilschifter, J., and Kunz, D., Mechanisms of suppression of inducible nitric-oxide synthase (iNOS) expression in interferon (IFN)-gamma-stimulated RAW 264.7 cells by dexamethasone. Evidence for glucocorticoidinduced degradation of iNOS protein by calpain as a key step in post-transcriptional regulation. J. BioI. Chem., 272, 16679-16687 (1997) 
  15. Ryu, S. Y., Kou, N. Y., Choi, H. S., Ryu, H., Kim, T. S., and Kim, K. M., Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells. Planta Med., 67, 172-174 (2001) 
  16. Kim, S. Y., Moon, T. C., Chang, H. W., Son, K. H., Kang, S. S., and Kim, H. P., Effects of tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses. Phytother. Res., 16, 616-620 (2002) 
  17. Jang, S. I., Jeong, S. I., Kim, K. J., Kim, H. J., Yu, H. H., Park, R., Kim, H. M., and You, YO., Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-alpha, IL-1beta and IL-6 in activated RAW 264.7 cells. Planta Med., 69, 1057-1059 (2003) 
  18. lm, S. Y., Han, S. J., Ko, H. M., Choi, J. H., Chun, S. B., Lee, D. G., Ha, T. Y., and Lee, H. K., Involvement of nuclear factorkappa B in platelet-activating factor- mediated tumor necrosis factor-alpha expression. Eur. J. Immunol., 27, 2800-2804 (1997) 
  19. Aga, M., Watters, J. J., Pfeiffer, Z. A., Wiepz, G. J., Sommer, J. A., and Berlics, P. J., Evidence for nucleotide receptor modulation of cross talkbetween MAP kinase and NF-kappa B signaling pathways in murine RAW 264.7 macrophages. Am. J. Physiol. Cell Physiol., 286, C923-C930 (2004) 
  20. Baeuerle, P. A. and Henkel, T., Function and activation of NF-kappa B in the immune system. Annu. Rev. Immunol., 12, 141-179 (1994) 
  21. Ryu, S. Y., Oak, M. H., and Kim, K. M., Inhibition of mast cell degranulation by tanshinones from the roots of Salvia miltiorrhiza. Planta. Med., 65, 654-655 (1999) 

이 논문을 인용한 문헌 (3)

  1. 2008. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 31(12): 1597~1603 
  2. 2008. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 31(6): 758~763 
  3. 2010. "" Natural product sciences, 16(4): 251~258 


원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일