$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

환경호르몬 비스페놀 A가 Xiphophorus maculatus의 생식에 미치는 영향

Effects of Environmental Endocrine Disruptor Bisphenol A on the Reproduction of Xiphophorus maculatus

초록

환경호르몬 비스페놀 A가 Xiphophorus maculatus의 생식에 미치는 영향을 알아보기 위하여 수컷을 100 ppb, 200 ppb, 400 ppb, 800 ppb의 농도에 3개월간 노출시킨 후 정상의 암컷과 교배시켜 치어수를 계수하여 수컷의 수정능력을 확인하였고, 치어를 6개월 동안 비스페놀 A에 노출시켜 치어의 암수비율, 기형율, 사망률 및 형태학적으로 정자형성과정을 조사하였다. 3개월간 비스페놀 A에 노출시킨 수컷과 정상인 암컷을 교배시켜 얻은 치어수는 정상대조군에서 평균 $19.00{\pm}3.02$마리였으나 비스페놀 A의 농도가 증가함에 따라서 치어수는 100 ppb에서 $11.50{\pm}2.22$마리, 200 ppb에서 $6.40{\pm}2.76$마리, 400 ppb에서 $5.70{\pm}1.34$마리 및 800 ppb에서 $3.70{\pm}2.11$마리로 감소하는 경향을 보였다. 치어의 암수비율은 비스페놀 A의 농도와 전혀 상관이 없었고 기형과 사망률은 0%였다. 노출시킨 지 6개월 후 정자형성과정은 800 ppb에서도 정상적으로 일어나고 있었다. 이상과 같이 비스페놀 A는 성전환, 수컷의 비율감소, 기형 및 사망에는 전혀 영향을 주지 않았고 단지 출생 개체수에만 영향을 주었다.

Abstract

In this study, we examined effects of environmental endocrine disruptor bisphenol A on the reproduction of Xiphophorus maculatus. We exposed the males of X. maculatus to the bisphenol A adjusted to the various concentrations such as 100 ppb, 200 ppb, 400 ppb and 800 ppb for 3 months for the experimental groups and then inbreeded with normal females that was not any treated. We counted the number of second generation for confirmation of fertilizing ability of first generation. Also, we observed the ratios of female and male, the abnormality and mortality, and spermatogenesis of the second generation was exposed to bisphenol A for 6 months. As the result, the number of fry in the second generation was $11.50{\pm}2.22$ in 100 ppb, $6.40{\pm}2.76$ in 200 ppb, $5.70{\pm}1.34$ in 400 ppb and $3.70{\pm}2.11$ in 800 ppb at the experimental groups while it was $19.00{\pm}3.02$ at the control group which was not treated with bisphenol A. This result showed that the experimental groups exhibited a decreasing tendency according to the increase of bisphenol A concentration comparing with the control group. The ratio of female and male of the second generation had no relations with the concentration of bisphenol A, and the ratios of abnormality and mortality were 0%. The spermatogenesis of experimental groups was normal in 800 ppb as well as 100 ppb, 200 ppb, 400 ppb after even 6 months.

저자의 다른 논문

참고문헌 (21)

  1. Barthold JS, Kryger JV, Derusha AM, Duel BP, Jednak R, Skafar DF: Effects of an environmental endocrine disruptor on fetal development, estrogen receptor$\alpha$ and epidermal growth factor receptor expression in the porcine male genital track. J Urol 162 : 864 871, 1999 
  2. Bergeron JM, Willingham E, Osborn T, Rhen T, Crews D: Developmental synergism of steroidal estrogens in sex determination. Environ Health Perspect 107(2): 93 97, 1999 
  3. Boockfor FR, Blake CA: Chronic administration of 4 tert octylphenol to adult male rats causes shrinkage of the testes and male accessory sex organs, disrupts spermatogenesis, and increases the incidence of sperm deformities. BioI Reprod 57 : 267 277, 1997 
  4. Brotons JA, Olea Serrano MF, Villalobos M, Pedraza V, Olea N: Xenoestrogens released from lacquer coating in food cans. Environ Health Perspect 103 : 608 612, 1995 
  5. Chikae M, Ikeda R, Hasan Q, Morita Y, Yamiya E: Effect of alkylphenols on adult male medaka: plasma vitellogenin goes up to the level of estrous female. Environ Toxicol Pharm 15 : 33 36, 2003 
  6. Estlander T, Jolanki R, Henriks Eckerman ML, Kanerva L: Occupational contact allergy to bisphenol A. Contact Dermatitis 40 : 52 53, 1999 
  7. Fossi MC, Casini S, Ancora S, Moscatelli A, Ausili A, Notarbartolo di Sciara G: Do endocrine disrupting chemicals threaten Mediterranean swordfish?Preliminary results of vitellogenin and zona radiata proteins in Xiphias gladius. Mar Environ Res 525 : 477 483, 2001 
  8. Gray MA, Metcalfe CD: Induction of testis ova in japanese medaka(Oryzias latipes) exposed to p nonylphenol. Environ Toxicol Chem 16(5) : 1082 1086, 1997 
  9. Gronen S, Denslow N, Manning S, Barnes S, Barnes D, Brouwer M: Serum vitellogenin levels and reproductive impairment of male japanese medaka (Oryzias latipes) exposed to 4 tert octylphenol, Environ Health Perspect 107(5) : 385 390, 1999 
  10. Honma S, Suzuki A, Buchanan DL, Katsu Y, Watanabe H, Iguchi T: Low dose effect of in vitero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction. Reprod Toxicol 16(2) : 117 122, 2002 
  11. Jobling S, Sheahan D, Osborne JA, Matthiessen P, Sumpter JP: Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals. Environ Toxicol Chem 15(2) : 194 202, 1996 
  12. Kang IJ, Yokota H, Oshima Y, Tsuruda Y, Yamaguchi T, Maeda M, Imada N., Tadokoro H, Honjo T: Effect of 17 beta estradiol on the reproduction of Japanese medaka (Oryzias latipes), Chemosphere 47(1) : 71 80, 2002 
  13. Kelce WR, Monosson E, Gamcsik MP, Laws SC, Gray LE Jr: Environmental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites. Toxicol Appl Pharmacol 126 : 276 285, 1994 
  14. Kim DH, Reu DS, Deung YK: An ultrastructural study on the spermatogenesis of Xiphophorus maculatus. Korean J Electron Microscopy 33(4) : 267 274, 2003.(Korean) 
  15. Lehtinen KJ, Mattsson K, Tana J, Engstrom C, Lerche O, Hemming J: Effect of wood related sterols on the reproduction, egg survival, and offspring of brown trout (Salmo trutta lacustris L.). Ecotoxicol Environ Safety 42 : 40 49, 1999 
  16. Nagao T, Saito Y, Usumi K, Yoshimura S, Ono H: Low dose bisphenol A does not affect reproductive organs in estrogen sensitive C57BL/6N mice exposed at the sexually mature, juvenile, or embryonic stage. Reprod Toxicol 16(2) : 123 130, 2002 
  17. Nikula H, Talonpoika T, Kaleva M, Toppari J: Inhibition of hCG stimulated steroidogenesis in cultured mouse Leydig tumor cells by bisphenol A and octylphenols. Toxicol Appl Pharmacol 157 : 166 173, 1999 
  18. Olea N, Pulgar R, Perez P, Olea Serrano F, Rivas A, Novillo Fertrell A, Pedraza V, Soto AM, Sonnenschein C: Estrogenicity of Resin based composites and sealants used in dentistry. Environ Health Perspect 104(3) : 298 305, 1996 
  19. Pait AS, Nelson JO: Vitellogenesis in male Fundulus heteroclitus (killifish)induced by selected estrogenic compounds. Aquatic Toxicology 64 : 331 342, 2003 
  20. Pickford DB, Morris ID: Effects of endocrine disrupting contaminants on amphibian oogenesis: Methoxychlor inhibits progesterone induced maturation of Xenopus laevis oocytes in Vitro. Environ Health Perspect 107(4) : 285 292, 1999 
  21. Steinmetz R, Brown NG, Allen DL Bigsby RM, Ben Jonathan N: The environmental estrogen bisphenol A stimulates prolactin release in Vitro and in Vivo. Endocrinology 138(5) : 1780 1786, 1997 

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

  • Korea Open Access Journals : 저널

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

이 논문 조회수 및 차트

  • 상단의 제목을 클릭 시 조회수 및 차트가 조회됩니다.

DOI 인용 스타일

"" 핵심어 질의응답