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Stringent Factor Regulates Antibiotics Production and Morphological Differentiation of Streptomyces clavuligerus 원문보기

Journal of microbiology and biotechnology, v.14 no.6, 2004년, pp.1170 - 1175  

RYU , YONG-GU (School of Biological Sciences, Seoul National University) ,  JIN, WOOK (School of Biological Sciences, Seoul National University) ,  KIM, JIN-YOUNG (School of Biological Sciences, Seoul National University) ,  KIM, JAE-YOUNG (School of Biological Sciences, Seoul National University) ,  LEE, SANG-HEE (Department of Biological Science, Myongji University) ,  LEE, KYE-JOON (School of Biological Sciences, Seoul National University)

Abstract ▼ AI-Helper 아이콘AI-Helper

The involvement of the relA and rsh genes in the morphological and physiological differentiation of Streptomyces clavuligerus was evaluated with the relA and rsh genes mutants. The morphological differentiation of S. clavuligerus was greatly affected by the disruption of the relA gene, but not very ...

주제어

#Clavulanic acid   #relA   #rsh   #ppGpp   #chemostat  

참고문헌 (23)

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  11. Kang, S. G., W. Jin, M. J. Bibb, and K. J. Lee. 1998. Actinorhodin and undecylprodigiosin production in wild type and relA mutant strains of Streptomyces coelicolor A3(2) grown in continuous culture. FEMS Microbiol. Lett. 168: 221-226 

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    상세보기 crossref

  19. Pirt, S. J. 1975. Parameters of growth and analysis of growth data, pp. 4-14 In: Principles of Microbe and Cell Cultivation. Blackwell, Oxford, U.K 

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  21. Sohng, J. K., H. C. Lee, K. Liou, E. B. Lee, S.-Y. Kang, and J.-S. Woo. 2003. Cystocin, a novel antibiotic, produced by Streptomyces sp. GCA0001: production and characterization of cystocin. J. Microbiol. Biotechnol. 13: 483-486 

  22. Strauch, E., E. Takano, H. A. Baylis, and M. J. Bibb. 1991. The stringent response in Streptomyces coelicolor A3(2). Mol. Microbiol. 5: 289-298 

  23. Sun, J., A. Hesketh, and M. J. Bibb. 2001. Functional analysis of relA and rshA, two relA/spoT homologues of Streptomyces coelicolor A3(2). J Bacteriol 183: 3488-3498 

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