[논문]Antiplatelet Activity of Thujopsis dolabrata var. hondai-Derived Component Against Platelet Aggregation

SON DONG JU; PARK YOUNG HYUN; KIM YOUNG MI; CHUNG NAM HYUN; LEE HOI SEON

Antiplatelet Activity of Thujopsis dolabrata var. hondai-Derived Component Against Platelet Aggregation 원문보기

Journal of microbiology and biotechnology, v.15 no.2, 2005년, pp.425 - 427

SON DONG JU (College of Natural Sciences, Soonchunhyang University) , PARK YOUNG HYUN (College of Natural Sciences, Soonchunhyang University) , KIM YOUNG MI (Research Center for Industrial Development of Biofood Materials and Faculty of Biotechnology, College of Agriculture, Chonbuk National University) , CHUNG NAM HYUN (College of Life and Environmental Sciences, Korea University) , LEE HOI SEON (Research Center for Industrial Development of Biofood Materials and Faculty of Biotechnology, College of Agriculture, Chonbuk National University)

Abstract ▼ AI-Helper

The steam distillate obtained from Thujopsis dolabrata var. hondai sawdust was fractionated by centrifugal thin-film evaporation, and the fractions were then investigated for antiplatelet activity using washed rabbit platelets. The biologically active constituent of T. dolabrata var. hondai sawdust was isolated by silica gel column and HPLC chromatographies and characterized as carvacrol by various spectral analyses. Carvacrol inhibited platelet aggregation induced by collagen, arachidonic acid, and platelet activating factor with IC$_{50}$ values of 12.6, 2.5, and 385.3 $\mu$M, respectively. However, carvacrol had no effect on thrombin, calcium ionophore A23l87, or phorbol l2-myristate l3-acetate induced platelet aggregation. Carvacrol was a much more potent inhibitor, as antiplatelet agents, compared with aspirin. These results suggest that carvacrol isolated from T. dolabrata var. hondai sawdust may be useful as a lead compound for inhibiting arachidonic acid-induced platelet aggregation.

참고문헌 (22)

Ahn, Y. J., S. B. Lee, T. Okubo, and M. Kim. 1995. Antignawing factor of crude oil derived from Thujopsis dolabrata S. et. Z. var. hondai sawdust against mice. J. Chemical Ecology 21: 263- 271

상세보기
Ahn, Y. J., S. B. Lee, H. S. Lee, and G. H. Kim. 1998. Insecticidal and acaricidal activity of carvacrol and $\beta-thujaplicine$ derived from Thujopsis dolabrata var, hondai sawdust. J. Chemical Ecology 24: 81- 90

상세보기
Balandrin, M., J. Klocke, E. S. Wurtele, and W. H. Bollinger. 1985. Natural plant chemicals: Sources of industrial and medicinal materials. Science 228: 1154- 1160

상세보기
Chang, F. R., J. L. Wei, C. M. Teng, and Y. C. Wu. 1998. Antiplatelet aggregation constituents from Annona purpurea. J. Nat. Prod. 61: 1457-1461

상세보기
Dinerman, J. L. and J. L. Mehta. 1990. Endothelial, platelet and leukocyte interactions in ischemic heart disease: Insights into potential mechanisms and their clinical relevance. J. Am. Cardiol. 16: 207- 222

상세보기
Enomoto, H., Y. Yoshikuni, Y. Yasutomi, K. Ohata, K. Sempuku, K. Kitaguchi, Y. Fujita, and T. Mori. 1997. Hypocholesterolemic action of tricyclic diterpenoids in rats. Chem. Pharm. Bull. 25: 507 - 510
Hasegawa. S. and Y. Hirose. 1982. Terpenoids from the seed of Thujopsis dolabrata var. dolabrata. Phytochemisty 21: 643- 646

상세보기
Hirsh. J. 1987. Hyperactive platelets and complications of coronary artery disease. N. Engl. J. Med. 316: 1543- 1544

상세보기
Hwang. Y. H. and H. S. Lee. 2002. Antibacterial activity of Pinus densijlora leaf-derived components toward human intestinal bacteria. J. Microbiol. Biotechnol. 12: 610- 616

원문보기 상세보기
Ito. M., M. Hamada. M. Arakawa, and F. Abe. 1980. Antimicrobiol activities of Hiba oil, Thujopsene and its various derivatives. Bokin Bobai 8: 3- 6
Kim. M. K. and H. S. Lee. 2002. Growth responses of various flower extracts toward human intestinal microflora. Food Sci. Biotechnol. 11: 444-447

상세보기
Lin. C. N. and C. M. Lu. 1996. Novel antiplatelet constituents from Formosan Moraceous plants. J. Nat. Prod. 59: 834- 838

상세보기
Packham, M. A. 1994. Role of platelets in thrombosis and hemostasis. Can. J. Physiol. Pharm. 72: 278- 284

상세보기
Rho. M. C., Y. H. Park. S. Sasaki. M. Ishibashi. K. Kondo. J. Kobayashi. and Y. Ohizumi. 1996. The mode of rabbit platelet shape change and aggregation induced by theonezolide-A. a novel polyketidc macrolide, isolated from the Okinawan marine sponge Theonella sp. Can. J. Physiol. Pharm. 74: 193- 199

상세보기
Ross. R. 1986. The pathogenesis of atherosclerosis: An update. N. Engl. J. Med. 314: 488- 500

상세보기
Samuelsson, B., M. Goldyne, E. Granstrom, M. Hamberg. S. Hammarstrom, and C. Malmsten. 1978. Prostaglandins and thromboxanes, Annu. Rev. Biochem. 47: 997- 1029

상세보기
Siess, W. 1989. Molecular mechanisms of platelet activation. Physiol. Rev. 69: 58- 178

상세보기
Singh. D. P., A. Kumar. and M. B. Tyagi. 2003. Biotoxic cyanobacterial metabolites exhibiting pesticidal and mosquito larvicidal activities, J. Microbiol. Biotechnol. 13: 50- 56

원문보기 상세보기
Son. D. J., S. E. Lee. and B. S. Park. 2003. Inhibitory effects of naturally occurring flavonoids on human intestinal bacterium. Clostridium perfringens. Food Sci. Biotechnol. 12: 180- 182

상세보기
Song, M. H., K. Sclvam, H. Y. Jeong. and K. S. Chae. 2003. Inhibition of asexual sporulation and growth of Aspergillus niger and Aspergillus oryzae by propylamine. J. Microbiol. Biotechnol. 13: 146- 148

상세보기
Tsai, W. J., W. C. Hsin, and C. C. Chen. 1996. Antiplatelet flavonoids from seeds of Psoralea corylifolia. J. Nat. Prod. 59: 671-672

상세보기
Tsai. I. L., W. Y. Lin, C. M. Teng, T. Ishikawa. S. L. Doong, M. W. Huang, Y. C. Chen, and I. S. Chen. 2000. Coumarins and antiplatelet constituents from the root bark of Zanthoxylum schinifolium. Planta Medica 66: 618- 723

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