[논문]Chronic Alcohol Consumption Induced Tibial Bone Loss and Resulted in Osteopenia in Growing Young Male Rats

Kwak Chung Shil; Song Kye Yong; Park Sang Chul

Chronic Alcohol Consumption Induced Tibial Bone Loss and Resulted in Osteopenia in Growing Young Male Rats 원문보기

Nutritional sciences, v.8 no.2, 2005년, pp.89 - 96

Kwak Chung Shil (Aging and Physical Culture Research Institute, Seoul National University) , Song Kye Yong (Department of Pathology, Chung-Ang University College of Medicine) , Park Sang Chul (Department of Biochemistry, Seoul National University College of Medicine)

Abstract ▼ AI-Helper

To determine the deleterious effects of chronic alcohol consumption on bone especially in adolescents or young adults, 8 week-old Sprague Dawley male rats were fed with Lieber-Decarli ethanol liquid diet, containing $36\%$ of energy as ethanol, ad libitum (ethanol group) or isocaloric normal liquid diet (control group) for 7 weeks. Body weight was significantly lower in ethanol group than that in control group after 1 week of feeding to the end. liver weight and the ratio of liver or kidney weight to body weight in ethanol group were significantly increased when compared to those in control group. Ethanol group showed significantly lower serum protein and albumin levels (p<0.05), higher total cholesterol and HDL-cholesterol levels (p<0.05), and AST, ALT and BUN activities than control group, but serum triglyceride, Ca and phosphate levels were not different. Ethanol group had significantly lower tibial trabecular bone area and serum osteocalcin level than control group (p<0.05), but urinary Ca and NTx (cross-linked N-telopeptide of type I collagen) concentrations and serum testosterone and parathyroid hormone levels were not different. In conclusion, chronic alcohol consumption in growing young male rats may result in osteopenia through the reduction of bone formation as well as liver malfunction.

주제어

AI 본문요약
AI-Helper

* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.

제안 방법

Sixteen male Sprague-Dawley rats, 8 weeks of age, were maintained under standard conditions (22-25 ℃, 12 hrs light/dark cycle). All animals were acclimatized to standard rat chow (Samyang, Korea) and water ad libitum for 1 week and then randomly allocated to control or ethanol group, 8 rats per each. Lieber-Decarli ethanol diet mixture and control diet mixture for rats were purchased from Dyets Inc.
The chronic consumption of alcohol in adolescence and young adulthood has significant negative effects on bone growth that remains partially uncompensated in adulthood, 21) results in serious multiple health problems as well as early-onset of osteoporosis. O니!' purpose in this study was to determine the deleterious effects of chronic alcohol consumption on bone especially in adolescents or young adults, using a rat model fed with Lieber-Decarli ethanol liquid diet or isocaloric control liquid diet.

데이터처리

Data were expressed as means ± SD. Statistical significance of difference between the means of two groups was determined by student's t-test using SAS program.

이론/모형

, Korea). Cross-linked N-telopeptide of type I collagen (NTx) in urine was determined by ELISA method using a commercial kit (Brahams, Germany).

참고문헌 (47)

Orwoll ES. Osteoporotisis in men. In: Primer on the metabolic bone diseases and disorders of mineral metabolism. Fifth ed. Am Soc Bone Miner Res, pp360-364, Washington DC, 2003
Amin S, Felson DT. Osteoporosis in men. Rheum Dis Clin North Am 27:19-47, 2001

상세보기
Sampson HW, Hebert VA, Booe HL, Champney TH. Effect of alcohol consumption on adult and aged bone: composition, morphology, and hormone levels of a rat animal model. Alcohol Clin Exp Res 22:1746-1753, 1998
Turner RT. Skeletal response to alcohol. Alcohol Clin Exp Res 24:1693-1701, 2000

상세보기
Hogan HA, Argueta F, Moe L, Nguyen LP, Sampson HW. Adult-onset alcohol consumption induces osteopenia in female rats. Alcohol Clin Exp Res 25:746-754, 2001

상세보기
Santolaria F, Gonzalez-Reimers E, Perez-Manzano JL, Milena A, Gomez-Rodriguez MA, Gonzalez-Diaz A, de la Vega MJ, Martinez-Riera A. Osteopenia assessed by body composition analysis is related to malnutrition in alcoholic patients. Alcohol 22(3):147-157, 2000

상세보기
Bikle DD, Stesin A, Halloran B, Steinbach L, Recker R. Alcohol-induced bone desease: Relationship to age and parathyroid hormone levels. Alcohol Clin Exp Res 17:690-695, 1993

상세보기
Nielsen HK, Lundby L, Rasmussen K, Charles P, Hansen C. Alcohol decreases serum osteocalcin in a dose-dependent way in normal subjects. Calcif Tissue Int 46:173-178, 1990

상세보기
Dyer SA, Buckendahl P, Sampson HW. Alcohol consumption inhibits osteoblastc cell proliferation and activity in vivo. Alcohol 16:337-341, 1998

상세보기
Laitinen K, Valimaki M. Alcohol and bone. Calcif Tissue Int 49:S70-73, 1997

상세보기
Latinen K, Tahtela R, Luomanmaki K, Valimaki MJ. Mechanisms of hypocalcemia and markers of bone turnover in alcohol-intoxicated drinkers. Bone Miner 24:171-179, 1994

상세보기
Dai J, Lin D, Zhang J, Habib P, Smith P, Murtha J, Fu Z, Uao Z, Qi Y, Keller ET. Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice. J Clin Invest 106:887-895, 2000

상세보기
Zhang J, Dai J, Lin D, Habib P, Smith P, Murtha J, Fu Z, Yao Z, Qi Y, Keller ET. Osteoprotegerin abrogated chronic alcohol ingestion-induced bone loss in mice. J Bone Mine Res 17(7):1256-1263, 2002

상세보기
Diez A, Puig J, Serrano S, Marinoso ML, Bosch J, Marrugat J, Mellibovsky L, Nogues X, Knobel H, Aubia J. Alcohol-induced bone disease in the absence of severe chronic liver damage. J Bone Miner Res 9:825-831, 1994

상세보기
Nam J, Kim H, Choi E. Report on 1998 National health and nutritional survey: Health. Kor J Community Nutr 5(3):537-548, 2000
Report on the social statistics survey. Korea National Statistical Office, 2003
Lee MS, Woo MK. Differences in the dietary and health-related habits and quality of diet in university students living in Daejon. Kor J Community Nutr 8(1):33-40, 2003
Kim KH. A study of the dietary habits, the nutritional knowledge and the consumption patterns of convenience foods of university students in the Gwangju area. Kor J Community Nutr 8(2):181-191, 2003
Kim IS, Yu HH, Han HS. Effects of nutrition knowledge, dietary attitude, dietary habits and life style on the health of college students in Chungnam area. Kor J Community Nutr 7(1):45-57, 2002
Report on 2001 National health and nutritional survey. Ministry of Health and Welfare, 2002
Sampson HW, Spears H. Osteopenia due to chronic alcohol consumption by young actively growing rats is not completely reversible. Alcohol Clin Exp Res 23(2):324-327, 1999

상세보기
Arlet J. Nontraumatic avascular necrosis of the femoral head: Past, present, and future. Clin Orthop 277:12-21, 1992
Mont MA, Hungerford DS. Nontraumatic avascular necrosis of the femoral head. J Bone Joint Surg 77A:457-474, 1995
Elmani N, Ertem K, Ozen S, Inan M, Baysal T, Guner G, Bora A. Fracture healing and bone mass in rats fed on liquid diet containing ethanol. Alcohol Clin Exp Res 26(4):509-513, 2002

상세보기
Srivastava AK, Bhattacharyya S, Castillo G, Wergedal J, Mohan S, Baylink DJ. Development and application of serum C-telopeptide and osteocalcin assay to measure bone turnover in an ovariectomized rat model. Calcif Tissue Int 66:435-442, 2000

상세보기
Gorski JP, Apone S, Shaffer KA, Batchelder A, Jean W, Williams JA, Shacter E, Eyre DR. Hypercalcemia during the osteogenic phase after rat marrow ablation coincides with increased bone resorption assessed by the NTx marker. Bone 27:103-110, 2000

상세보기
Wezeman FH, Emanuele MA, Emanule NV, Moskal SF, Woods M, Suri M, Steiner J, LaPaglia N. Chronic alcohol consumption during male rat adolescence impairs skeletal development through effects on osteoblast gene expression, bone mineral density and bone strength. Alcohol Clin Exp Res 23:1534-1542, 1999

상세보기
Wezeman FH, Emanuele MA, Moskal SF, Steiner J, LaPaglia N. Alendronate administration and skeletal response during chronic alcohol intake in the adolescent male rat. J Bone Mine Res 15(10):2033-2041, 2000

상세보기
Brown EC, Perrin DS, Fletcher TW, Irby DJ, Aronson J, Gao GG, Hogue WJ, Skinner RA, Suva LJ, Ronis MJJ, Hakkak R, Badger TM, Lumpkin CK. Skeletal toxicity associated with chronic ethanol exposure in a rat model using total enteral nutrition. J Pharm Exp Ther 301:1132-1138, 2002

상세보기
Cheung RCY, Gray C, Boyde A, Jones SJ. Effects of ethanol on bone cells in vitro resulting in increased resorption. Bone 16:143-147, 1995

상세보기
Friday KE, Howard GA. Ethanol inhibits human bone cell proliferation and function in vitro. Metabolism 40(6):562-565, 1991

상세보기
Klein RF, Carlos AS. Inhibition of osteoblastic cell proliferation and ornithine decarboxylase activity by ethanol. Endocrinology 136:3406-3411, 1995

상세보기
Klein RF, Fausti KA, Carlos AS. Ethanol inhibits human osteoblastic cell proliferation. Alcohol Clin Exp Res 20:572-578, 1996

상세보기
Latinen K, Lamberg-Allardt C, Tunninen R, Karonen SL, Tahtela R, Ylikahri R, Latinen K, Lamberg-Allardt C, Tunninen R, Karonen SL, Ylikahri R, Valimaki M. Effects of 3 weeks' moderate alcohol intake on bone and mineral metabolism in normal men. Bone Miner 13:139-151, 1991

상세보기
Peng TC, Gitelman HJ. Ethanol-induced hypocalcemia, hypomagnesemic in rats and dogs. Endocrinology 91:586-593, 1974

상세보기
Rico H, Cabranes JA, Cabello J, Gomez-Castresana F, Hernandez ER. Low serum osteocalcin in acute alcohol intoxication: A direct toxic effect of alcohol on osteoblasts. Bone Miner 2:221-225, 1987
Ilich JZ, Brownbill RA, Tanborini L, Crncevic-Orlic. To drink or not to drink: How are alcohol, caffeine and past smoking related to bone mineral density in elderly women? J Am College Nutr 21(6):536-544, 2002

상세보기
Yamamoto A, Sekino A, Tajima M, Nguyen VC, Ezawa I. Effect of long-term alcohol administration on born metabolism in rats. J Nutr Sci Vitam (Tokyo) 43(3):369-375, 1997

상세보기
Perry HM III, Horowitz M, Fleming S, Kaiser FE, Patrick P, Morley JE, Cushman W, Binghm S, Perry HM. The effects of season and alcohol intake on mineral metabolism in men. Alcohol Clin Exp Res 23(2):214-219, 1999

상세보기
Bikle DD, Genant HK, Cann CH, Recker RR, Halloran BP, Strewlwe GJ. Bone disease in alcohol abuse. Ann Int Med 103:42-48, 1985

상세보기
Diamond TH, Stiel D, Lunzer M, Wilkinson M, Posen S. Ethanol reduces bone formation and may cause osteoporosis. Am J Med 86:282-288, 1989

상세보기
Valimaki M. Transient hypoparathyroidism during acute alcohol intoxication. New Engl Med 324:721-727, 1991

상세보기
Diez A, Serrano S, Cucurull J, Marinoso L, Bosch J, Puig J, Nogues X, Aubia J. Acute effects of ethanol on mineral metabolism and trabecular bone in Sprague-Dawley rats. Calcif Tissue Int 61(2):168-171, 1997

상세보기
Steiner J, Halloran M, LaPaglia N, Emanuele NV, Emanuele MA. Effect of chronic ethanol on reproductive and growth hormone in peripubertal rat. J Endocrinol 154:363-370, 1997

상세보기
Emanuele MA, LaPaglla N, Steiner J, Jabamoni K, Hansen M, Kirsteins L. Emanuele NV. Reversal of ethanol-induced testosterone suppression in peripubertal male rats by opiate blockade. Alcohol Clin Exp Res 22(6):1199-1204, 1998

상세보기
Little PJ, Adams ML, Cicero TJ. Effects of alcohol on the hypothalamic pituitary-gonadal axis in the developing males. J Phamacol Exp Ther 263:1056-1061, 1992
Adams ML, Cicero TJ. Effects of alcohol on beta-endorphin and reproductive hormones in the male rat. Alcohol Clin Exp Res 15:685-692, 1991

상세보기

저자의 다른 논문 :

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증