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논문 상세정보


The methanolic extract from the seeds of Arctium lappa was found to inhibit the LPS-induced nitric oxide (NO) production in murine macrophage RAW264.7 cells. Bioassay-guided fractionation of a methylene chloride soluble fraction led to the isolation of three lignan compounds, arctiin (1), arctigenin (2), and lappaol B (3). Their structures were elucidated by UV, IR, MS, and NMR data, as well as by comparison with those of the literatures. Arctigenin (2) and lappaol B (3) had an iNOS inhibitory activity with $IC_{50}$ values of 12.5 and $25.9\;{\mu}M$, respectively.

참고문헌 (18)

  1. Cho, M.K., Jang, Y.P., Kim, Y.C., and Kim, S.G. Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-${\alpha}$ inhibition. Int. Immunopharmacol. 4, 1419-1429 (2004) 
  2. Ichihara, A, Numata, Y., Kanai, S., and Sakamura, S., New sesquilignans from Arctium lappa L. The structure of lappaol C, D and E. Agric. Biol. Chem. 41, 1813-1814 (1977) 
  3. Ichihara, A., ada, K., Numata, Y., and Sakamura, S., Lappaol A and B, novel lignans from Arctium lappa. Tetrahedron Lett. 17,3961-3964 (1976) 
  4. Iwakami, S., Wu, J.B., Ebizuka, Y., and Sankawa, U., Platelet activating factor (PAP) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem. Pharm. Bull. 40, 1196-1198 (1992) 
  5. Moncada, S., Palmer, R.M., and Higgs, E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43, 109-142 (1991) 
  6. Tundis, R., Statti, G., Menichini, F., and Delle Monache, F. Arctiin and onopordopicrin from Carduus micropterus ssp. perspinosus. Fitoterapia 71, 600-601 (2000) 
  7. Schmidt, H. H. H. W., and Kelm, M. Determination of nitrite and nitrate by the Griess reaction. In: Methods in Nitric Oxide Research. John Wiley & Sons Ltd., London, 1996, pp. 491-497 
  8. Ichihara, A, Nakamura, Y., Kawagishi, H., and Sakamura, S., Stereochemistry of lappaol A and F. Tetrahedron Lett. 20, 3735-3738 (1979) 
  9. Umehara, K., Sugawa, A., Kuroyanagi, M., Ueno, A., and Taki, T. Studies on differentiation-inducers from Arctium fructus. Chem. Pharm. Bull. 41, 1774-1779 (1993) 
  10. Cho, M.K., Park, J.W., Jang, Y.P., Kim, Y.C., and Kim, S.G. Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-${\kappa}B{\alpha}$ phosphorylation and of p65 nuclear translocation in macrophages. Int. Immunopharmacol. 2, 105-116 (2002) 
  11. Koubaa, I., Damak, M., McKillop, A., and Simmonds, M. Constituents of Cynara cardunculus. Fitoterapia 70, 212-213 (1999) 
  12. Umehara, K., Nakamura, M., Miyase, T., Kuroyanagi, M., and Ueno, A Studies on differentiation inducers. VI. Lignan derivatives from Arctium fructus. (2). Chem. Pharm. Bull. 44, 2300-2304 (1996) 
  13. Cho J.Y., Kim, A.R., Yoo, E.S., Baik, K.U., and Park, M.H., Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-a and nitric oxide production, and lymphocyte proliferation. J. Pharm. Pharmacol. 51, 1267-1273 (1999) 
  14. Scudiero, D.A., Shoemaker, R.H., Paull, K.D., Monks, A., Tierney, S., Nofziger, T.H., Currens, M.J., Seniff, D., and Boyd, M.R. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res. 48, 4827-4833 (1988) 
  15. Jung, B.S. and Shin, M.K., Encyclopedia of illustrated Korean natural drugs. Young Lim Sa, Seoul, 1989, pp.1010-1012 
  16. Ichihara, A., Kanai, S., Nakamura, Y., and Sakamura, S., Structures of lappaol F and H, dilignans from Arctium lappa. Tetrahedron Lett. 19, 3035-3038 (1978) 
  17. Han, B.H., Kang, Y.H., Yang, H.O., and Park, M.K., A butyrolactone lignan dimer from Arctium lappa. Phytochemistry 37, 1161-1163 (1994) 
  18. Anggard, E. Nitric oxide: mediator, murderer, and medicine. Lancet 343, 1199-1206 (1994) 

이 논문을 인용한 문헌 (3)

  1. 2006. "" Natural product sciences, 12(4): 221~225 
  2. 2011. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 34(9): 1459~1466 
  3. Kim, Mi-Sun ; Lee, Ye-Seul ; Sohn, Ho-Yong 2014. "Anti-thrombosis and anti-oxidative activity of the root of Arctium lappa L." 한국식품저장유통학회지 = Korean journal of food preservation, 21(5): 727~734 


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