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논문 상세정보

Abstract

The methanolic extract from the seeds of Arctium lappa was found to inhibit the LPS-induced nitric oxide (NO) production in murine macrophage RAW264.7 cells. Bioassay-guided fractionation of a methylene chloride soluble fraction led to the isolation of three lignan compounds, arctiin (1), arctigenin (2), and lappaol B (3). Their structures were elucidated by UV, IR, MS, and NMR data, as well as by comparison with those of the literatures. Arctigenin (2) and lappaol B (3) had an iNOS inhibitory activity with $IC_{50}$ values of 12.5 and $25.9\;{\mu}M$, respectively.

참고문헌 (18)

  1. Cho, M.K., Jang, Y.P., Kim, Y.C., and Kim, S.G. Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-${\alpha}$ inhibition. Int. Immunopharmacol. 4, 1419-1429 (2004) 
  2. Ichihara, A, Numata, Y., Kanai, S., and Sakamura, S., New sesquilignans from Arctium lappa L. The structure of lappaol C, D and E. Agric. Biol. Chem. 41, 1813-1814 (1977) 
  3. Ichihara, A., ada, K., Numata, Y., and Sakamura, S., Lappaol A and B, novel lignans from Arctium lappa. Tetrahedron Lett. 17,3961-3964 (1976) 
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  13. Cho J.Y., Kim, A.R., Yoo, E.S., Baik, K.U., and Park, M.H., Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-a and nitric oxide production, and lymphocyte proliferation. J. Pharm. Pharmacol. 51, 1267-1273 (1999) 
  14. Scudiero, D.A., Shoemaker, R.H., Paull, K.D., Monks, A., Tierney, S., Nofziger, T.H., Currens, M.J., Seniff, D., and Boyd, M.R. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res. 48, 4827-4833 (1988) 
  15. Jung, B.S. and Shin, M.K., Encyclopedia of illustrated Korean natural drugs. Young Lim Sa, Seoul, 1989, pp.1010-1012 
  16. Ichihara, A., Kanai, S., Nakamura, Y., and Sakamura, S., Structures of lappaol F and H, dilignans from Arctium lappa. Tetrahedron Lett. 19, 3035-3038 (1978) 
  17. Han, B.H., Kang, Y.H., Yang, H.O., and Park, M.K., A butyrolactone lignan dimer from Arctium lappa. Phytochemistry 37, 1161-1163 (1994) 
  18. Anggard, E. Nitric oxide: mediator, murderer, and medicine. Lancet 343, 1199-1206 (1994) 

이 논문을 인용한 문헌 (3)

  1. 2006. "" Natural product sciences, 12(4): 221~225 
  2. 2011. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 34(9): 1459~1466 
  3. Kim, Mi-Sun ; Lee, Ye-Seul ; Sohn, Ho-Yong 2014. "Anti-thrombosis and anti-oxidative activity of the root of Arctium lappa L." 한국식품저장유통학회지 = Korean journal of food preservation, 21(5): 727~734 

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