[논문]Inhibitory Constituents of LPS-induced Nitric Oxide Production from Arctium lappa

Park, So-Young; Hong, Seong-Su; Han, Xiang-Hua; Ro, Jai-Seup; Hwang, Bang-Yeon

Inhibitory Constituents of LPS-induced Nitric Oxide Production from Arctium lappa 원문보기

Natural product sciences, v.11 no.2, 2005년, pp.85 - 88

Park, So-Young (College of Pharmacy, Chungbuk National University) , Hong, Seong-Su (College of Pharmacy, Chungbuk National University) , Han, Xiang-Hua (College of Pharmacy, Chungbuk National University) , Ro, Jai-Seup (College of Pharmacy, Chungbuk National University) , Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University)

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The methanolic extract from the seeds of Arctium lappa was found to inhibit the LPS-induced nitric oxide (NO) production in murine macrophage RAW264.7 cells. Bioassay-guided fractionation of a methylene chloride soluble fraction led to the isolation of three lignan compounds, arctiin (1), arctigenin (2), and lappaol B (3). Their structures were elucidated by UV, IR, MS, and NMR data, as well as by comparison with those of the literatures. Arctigenin (2) and lappaol B (3) had an iNOS inhibitory activity with $IC_{50}$ values of 12.5 and $25.9\;{\mu}M$, respectively.

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Plant material - The dried seeds of A. lappa were purchased from herbal drug store at Cheongju, Korea, in April, 2003 and identified by emeritus professor Kyong Soon Lee, a plant taxonomist at Chungbuk National University. The voucher specimens (CBNU 03021) were deposited at the Herbarium of College of Pharmacy, Chungbuk National University.
lappa were purchased from herbal drug store at Cheongju, Korea, in April, 2003 and identified by emeritus professor Kyong Soon Lee, a plant taxonomist at Chungbuk National University. The voucher specimens (CBNU 03021) were deposited at the Herbarium of College of Pharmacy, Chungbuk National University.

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