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Effects of Adenylate Cyclase, Guanylate Cyclase and KATP Channel Blockade on the Cerebral Blood Flow Response Induced by Adenosine A2B Receptor Agonist in the Rats 원문보기

The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology, v.13 no.1, 2005년, pp.35 - 40  

Youn, Doo-Sang (Department of Pharmacology, College of Medicine, Hanyang University) ,  Shin, In-Chul (Department of Pharmacology, College of Medicine, Hanyang University)

Abstract AI-Helper 아이콘AI-Helper

This study was performed to investigate the regulatory mechanism of cerebral blood flow of adenosine A$_{2B}$ receptor agonist in the rats, and to define whether its mechanism is mediated by adenylate cyclase, guanylate cyclase and potassium channel. In pentobarbital-anesthetized, pancuro...

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제안 방법

  • However, little is known about the regulatory mechanism of cerebral blood flow of adenosine A2B receptor agonist in the rats. This study was performed to examine the regulatory mechanism of cerebral blood flow of adenosine A2B receptor agonist in the rats, and to define whether its mechanism is mediated by adenylate cyclase, guanylate cyclase and potas­ sium channel.

대상 데이터

  • The experimental animals, male Sprague-Dawley rats (250- 300 gm), were categorized into five groups. The first group of the these groups was treated only with 5'-?/-ethylcarboxami- doadenosine (NECA; 4 umol/1), an adenosine A2B receptor agonist, topically to the cerebral cortex.

데이터처리

  • The statistical analysis of mean values was performed by analysis of variance (ANOVA). Student's r-test for paired data was also used for statistical evaluation of the results.
  • 01 considered as the level of significance. The statistical analysis of mean values was performed by analysis of variance (ANOVA). Student's r-test for paired data was also used for statistical evaluation of the results.
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