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Abstract

In the course of screening for selective growth inhibitors against the mycelial form of Candida albicans, we isolated a Streptomyces sp. A6792 from soils. The inhibitor was isolated from the above bacterium and identified through several spectral analyses with UV and mass spectrophotometries, and various NMR. The compound was determined to be a macrocyclic dilactone antibiotic, IKD-8344 (molecular weight: 844, molecular formula: $C_{48}H_{76}O_{12}$). The compound selectively inhibited the growth of mycelial form of C. albicans with an MIC of 6.25 ${\mu}g/ml$. It also exhibited strong inhibitory effect preferentially on the mycelial form of various Candida spp. including C. krusei, C. tropicalis, and C. lusitaniae, with MICs ranging from 1.56 to 25 ${\mu}g$/ml. Furthermore, the compound showed no significant toxicity against SPF ICR mice up to 60 mg/kg. These results suggest that IKD-8344 is a useful lead compound for the development of novel antifungal agents, based on the preferential growth inhibition against Candida spp.

참고문헌 (17)

  1. Sudberg, P., N. Gow, and J. Berman. 2004. The distinct morphogenic states of Candida albicans. Trends Microbiol. 12: 317-324 
  2. Calderone, R. A. and W. A. Fonzi. 2001 Virulence factors of Candida albicans. Trends Microbiol. 9: 327-335 
  3. Haynes, K. 2001. Virulence in Candida species. Trends Microbiol. 9: 591-596 
  4. Edmond, M. B., S. E. Wallace, D. K. Mcclish, M. A. Pfaller, R. N. Jones, and R. P. Wenzel. 1999. Nosocomial bloodstream infections in the United States hospitals: A three-year analysis. Clin. Infect. Dis. 29: 239-244 
  5. Lo, H. T., J. R. Kohler, B. DiDomenico, D. Loebenberg, A. Cacciapuoti, and G. R. Fink. 1997. Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939-949 
  6. Gale, C. A., C. M. Bendel, M. McClellan, M. Hauser, J. M. Becker, J. Berman, and M. K. Hostetter. 1998. Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INTI. Science 279: 1355-1358 
  7. Mcginnis, M. R. and M. G. Rinaldi. 1986. Antifungal drugs: Mechanisms of action, drug resistance, susceptibility testing, and assays of activity in biological fluids, pp. 243-260. In V. Lorian (ed.), Antibiotics in Laboratory Medicine. Williams & Wilkins, Baltimore 
  8. Locci, R. 1989. Streptomycetes and related genera, pp. 2451-2492. In S. T. Williams, M. E. Sharpe, and J. G. Holt (eds.), Bergey's Manual of Systematic Bacteriology, Vol. 4. Williams and Wilkins, Baltimore 
  9. Brown, A. J. P. and N. A. R. Gow. 1999. Regulatory networks controlling Candida albicans morphogenesis. Trends Microbiol. 7: 333-338 
  10. Cutler, J. E. 1991. Putative virulence factors of Candida albicans. Annu. Rev. Microbiol. 45: 187-218 
  11. Wenzet, R. P. 1995. Nosocomial candidiasis: Risk factors and attributable mortality. Clin. Infect. Dis. 20: 1531-1534 
  12. Sudoh, M., T. Yamazaki, K. Masucuchi, M. Taniguchi, N. Shimma, M. Arisawa, and H. Yamada-Okabe. 2000. Identification of a novel inhibitor specific to the fungal chitin synthase. J. Biol. Chem. 276: 32901-32906 
  13. Minami, Y., K. I. Yoshida, R. Azuma, M. Nishii, J. I. Inagaki, and F. Nohara. 1992. Structure of a novel macrodiolide antibiotic IKD-8344. Tetrahedron Lett. 33: 7373-7376 
  14. Pfaller, M. A., D. J. Diekema, R. N. Jones, H. S. Sader, A. C. Fluit, R. J. Hollis, and S. A. Messer. 2001. International surveillance of bloodstream infections due to Candida species; frequency of occurance and in vitro susceptibilities to fluconazole, ravuconazole, and voriconazole of isolates collected from 1997 through 1999 in the SENTRY antimicrobial surveillance program. J. Clin. Microbiol. 39: 3254-3259 
  15. Hwang, E. I., B. S. 'Vun, S. H. Lee, S. K. Kim, S. J. Lim, and S. U. Kim. 2004. 7-Oxostaurosporine selectively inhibit the mycelial form of Candida albicans. J. Microbiol. Biotechnol. 14: 1067-1070 
  16. Gow, N. A. R., A. J. P. Brown, and F. C. Odds. 2002. Fungal morphogenesis and host invasion. Curr. Opin. Microbiol. 5: 366-371 
  17. Leberer, E., D. Harcus, J. D. Broadbent, K. L. Clark, D. Dignard, K. Ziegelbauer, A. Schmidt, N. A. R. Gow, A. J. P. Brown, and D. Y. Thomas. 1996. Signal transduction through homo logs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proc. Natl. Acad. Sci. USA 93: 13217-13222 

이 논문을 인용한 문헌 (3)

  1. 2006. "" Journal of microbiology and biotechnology, 16(10): 1597~1604 
  2. 2007. "" Journal of microbiology and biotechnology, 17(3): 403~407 
  3. 2007. "" Journal of microbiology and biotechnology, 17(3): 534~538 

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