[논문]Effects of Ethanol Extract of Potato (Solanum tuberlosum) on Freund's Complete Adjuvant-induced Model of Chronic Arthritis in Mice

Choi, Eun-Mi; Lee, Kyung-Hee; Koo, Sung-Ja

Effects of Ethanol Extract of Potato (Solanum tuberlosum) on Freund's Complete Adjuvant-induced Model of Chronic Arthritis in Mice 원문보기

Choi, Eun-Mi (Department of Food & Nutrition, Kyung-Hee University) , Lee, Kyung-Hee (Department of Food Service Management, Kyung-Hee University) , Koo, Sung-Ja (Department of Food & Nutrition, Kyung-Hee University)

The effect of a potato ethanol extract was investigated on Freund's complete adjuvant (FCA)-induced arthritis. The oral administration of the potato extract, at doses of 100 and 200 mg/kg once a day for 21 days, significantly reduced hindpaw swelling and the production of inflammatory cytokines (TNF-${\alpha}$, IL-$1{\beta}$ and IL-6). Treatment with the potato extract also decreased the plasma levels of creatinine, triglyceride and LDL-cholesterol, and the activities of AST and ALT compared with those of a control group. These results suggest that the potato extract might be beneficial in the treatment of chronic inflammatory disorders.

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가설 설정

A number of studies have confirmed that HDL attenuates the cytokine-induced expression of the adhesion molecules in cultured endothelial cells (23). Because TNF-a and IL-ip increase the expression of endothelial leukocyte adhesion molecules, due to activation of the transcription factor NF-kB, it is hypothesized that HDL inhibits the activation of NF-kB. HDL also suppresses the caspases required for apoptosis, which are activated by TNF-oc, and appears to modulate the permeability of the endotheli_나m to LDL.

제안 방법

For the assessment of chronic inflammation, arthritis was induced by a FCA injection, with the potato extract administered orally at doses of either 100 or 200 ㎎/㎏ daily for 21 days. The body weight gains of the mice are given in Table 1.
Mice were randomly divided into five groups (n =7), these bein_응a normal untreated control group, control group injected with FCA and an orally administered vehicle, and treated groups injected with FCA and orally administered indomethacin (10 ㎎/㎏) and potato extract (100 and 200 ㎎/㎏) daily for 21 days. The body weights were measured before injection of the adjuvant (day 0).
These results indicated no liver and kidney failure in the potato extract treated mice. To corroborate the apparent lack of toxicity in both the kidney and liver, as suggested above, by an analysis of blood parameters, a histopathological study of these organs was also carried out. Histological examinations of the liver and kidney, used as target organs, showed no marked differences between the normal control and potato extract treated groups, and no evident alterations were detected (results not shown).

대상 데이터

Potatoes were obtained from a market in Seoul, Korea, and were peeled to a depth of ~1 mm with a vegetable peeler. The fresh blended potatoes were immediately extracted three times in EtOH, the extract filtered and concentrated with a rotary evaporator at temperature below 50℃ and then freeze dried (yield: 2.

데이터처리

The results are expressed as the means ± SEM (n=5). Statistical significance was determined by an analysis of variance and subseq_나ent Duncan's multiple range test (P<0.05). The analysis was performed using the SAS statistical software.

성능/효과

In conclusion, the results of the present study clearly demonstrate that potato extract exerts potent anti-inflammatory actions in the FCA-induced chronic arthritis model; and thus, was found to be effective under chronic inflammatory conditions. Also, the above results indicated that the administration of 100 and 200 ㎎/㎏ of body weight/day of potato extract over 21 days showed no sign of toxicity, with most of the serum biochemical and hematological parameters remaining normal. In concl_나sion, potato extract might be proposed as a candidate for a novel treatment of chronic joint inflammation.
In conclusion, the results of the present study clearly demonstrate that potato extract exerts potent anti-inflammatory actions in the FCA-induced chronic arthritis model; and thus, was found to be effective under chronic inflammatory conditions. Also, the above results indicated that the administration of 100 and 200 ㎎/㎏ of body weight/day of potato extract over 21 days showed no sign of toxicity, with most of the serum biochemical and hematological parameters remaining normal.

후속연구

In concl_나sion, potato extract might be proposed as a candidate for a novel treatment of chronic joint inflammation. Further detailed investigations are underway to determine the exact phytoconstituents responsible for the anti-inflammatory activity.

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연합인증

Effects of Ethanol Extract of Potato (Solanum tuberlosum) on Freund's Complete Adjuvant-induced Model of Chronic Arthritis in Mice 원문보기

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