$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

Activity-guided fractionation of the CH$_2Cl_2$-soluble fraction of the roots of Sophora flavescens furnished five 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scaveng ers: trans-hexadecyl ferulic acid (1) cis-octadecyl ferulic acid (2), trans-hexadecyl sinapic acid (3), (-)-4-hydroxy-3-methoxy-(6aR,11aR)-8, 9-methylenedioxypterocarpan (4) and desmethylanhydroicaritin (8), along with nine known inactive compounds: (-)-maackiain (5), xanthohumol (6), formononetin (7), (2S)-2'-methoxykurarinone (9), (2S)-3${\beta}$,7,4'-trihydroxy-5-methoxy-8-(${\gamma},{\gamma}$- imethylallyl )-flavanone (10), (2S)-7,4'-dihydroxy-5-methoxy-8- (${\gamma},{\gamma}$-dimethylallyl ) -flavanone (11), umbelliferone (12), kuraridin (13), and trifolirhizin (14). Compounds 1-4 and 8 exhibited DPPH free radical scavenging effects at IC$_{50}$ values of 33.01 ${\pm}$ 0.20, 57.06 ${\pm}$ 0.16, 39.84 ${\pm}$ 0.36, 35.83 ${\pm}$ 0.47, and 18.11 ${\pm}$ 0.04${\mu}$M, respectively. L-Ascorbic acid, when used as a positive control, exhibited an IC$_{50}$ value of 7.39 ${\pm}$ 0.01 ${\mu}$M. Compounds 1-4 and 8 also appeared to exert significant scavenging effects on authentic ONOO-, with IC$_{50}$ values of 5.76 ${\pm}$ 1.19, 15.06 ${\pm}$ 1.64, 8.17 ${\pm}$ 4.97, 1.95 ${\pm}$ 0.29 and 4.06 ${\pm}$ 2.41 ${\mu}$M, respectively. Penicillamine (IC$_{50}$= 2.36 ${\pm}$ 0.79${\mu}$M) was used as a positive control. In addition, compounds 2,4,6,8, and 10 were isolated from this plant for the first time.

참고문헌 (31)

  1. Beckman, J. S., Beckman, T. W., Chen, J., Marshell, P. A., and Freeman, B. A., Apparent hydroxy radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. U.S.A., 87, 1620-1624 (1990) 
  2. Hatano, T., Edamatsu, R., Hiramatsu, M., Mori, A., Fujita, Y., Yasuhara, T., Yoshida, T., and Okuda, T., Effects of the interaction of tannins with co-existing substances VI. Effects of tannins and related polyphenols on superoxide anion radical, and on 1,1-diphenyl-2-picrylhydrazyl radical. Chem. Pharm. Bull., 37, 2016-2021 (1989) 
  3. Huang, K. C., The Pharmacology of Chinese Herbs, CRC Press, Boca Raton, pp 63-66 (1993) 
  4. Jung, N. I., Yook, C. S., and Lee, H. K., Coumarins from the roots of Angelica decursiva – albiflora. Kor. J. Pharmacogn., 25, 311-318 (1994) 
  5. Kang, T. H., Jeong, S. J., Ko, W. G., Kim, N. Y., Lee, B. H., Inagaki, M., Miyamato, T., Higuchi, R., and Kim, Y. C., Cytotoxic lavandulyl flavanones from Sophora flavescens. J. Nat. Prod., 63, 680-681 (2000) 
  6. Tabata, N., Ito, M., Tomoda, H., and Omura, S., Xanthohumols, diacyglycerol acyltransferase inhibitors, from Humulus lupulus. Phytochemistry, 46, 683-687 (1997) 
  7. Yoshikawa, M., Wang, H. K., Kayakiri, T. Taniyama, T., and Kitagawa, I., Saponin and sapogenol. XL. Structure of sophoraflavoside I, a bisdesmoside of soyasapogenol B, from Sophorae Radix, the root of Sophora flavescens Aiton. Chem. Pharm. Bull., 33, 4267-4274 (1985) 
  8. Kooy, N. W., Royall, J. A., Ischiropoulos, H., and Beckman, J. S., Peroxynitrite mediated oxidation of dihydrorhodamine 123. Free Radical Biol. Med., 16, 149-156 (1994) 
  9. Ding, Y., Tian, R. H., Kinjo, J., Nohara, T., and Kitagawa, I., Three new oleanene glycosides from Sophora flavescens. Chem. Pharm. Bull., 40, 2990-2994 (1992) 
  10. Jakupovic, J. J., Paredes, L., Bohlmann, F., and Watson, L., Prenyl flavans from Marshallia species. Phytochemistry, 27, 3273-3275 (1988) 
  11. Blois, M. S., Antioxidant determination by the use of a stable free radical. Nature, 181, 1199-1202 (1958) 
  12. Perry, L. M. and Metzger, J., Medicinal Plants of East and Southeast Asia: Attributed Properties and Uses. The MIT Press, Cambridge, pp 226 (1980) 
  13. Park, J. A., Kim, H. J., Jin, C. B., Lee, K. T., and Lee, Y. S., A new pterocarpan, (-)-maackiain sulfate, from the root of Sophora subprostrata. Arch. Pharm. Res., 26, 1009-1013 (2003) 
  14. Zhang, J. H., Zhao, Y. Y., Liu, Q. X., and Ye, X. J., Studies on the chemical constituents from Sophora flavescens Ait. China J. Chin. Mat. Med., 25, 37-38 (2000) 
  15. Balde, A. M., Claeys, M., Pieters, L. A., Wray, V., and Vlietinck, A. J., Ferulic acid esters from stem bark of Pavetta owariensis. Phytochemistry, 30, 1024-1026 (1991) 
  16. Komatsu, M., Tomimori, T., Hatayama, K., and Mikuriya, N., Studies on the constituents of Sophora species. IV. Constituents of the root of Sophora angustifolia Sieb. Et Zucc. (1). Yakugaku Zasshi, 90, 463-468 (1970) 
  17. Ding, P. L., Hou, A. J., and Chen, D. F., Three new isoprenylated flavonoids from the roots of Sophora flavescens. J. Asian Nat. Prod. Res., 7, 237-243 (2005) 
  18. Okuda, S., Murakoshi, I., Kamata, H., Kashida, Y., Haginiwa, J., and Tsuda, K., Studies on lupin alkaloids. I. The minor alkoloids of Japanese Sophora flavescens. Chem. Pharm. Bull., 13, 482-487 (1965) 
  19. Kim, J. S., Han, S. J., Byun, J. H., Xu, Y. N., Yoo, S. W., Kang, S. S., Son, K. H., Chang, H. W., and Kim, H. P., Minor constituents from the roots of Sophora flavescens. Nat. Prod. Sci., 7, 5-8 (2001) 
  20. Saito, K., Arai, N., Sekine, T., Ohmiya, S., Kubo, H., Otomasu, H., and Murakoshi, I., (-)-5$\alpha$-Hydroxysophocarpine, a new lupin alkaloid from the seeds of Sophora flavescens var. angustifolia. Planta Med., 56, 486-488 (1990) 
  21. Ryu, S. Y., Lee, H. S., Kim, Y. K., and Kim, S. H., Determination of isoprenyl and lavandulyl positions of flavonoids from Sophora flavescens by NMR experiment. Arch. Pharm. Res., 20, 491-495 (1997) 
  22. Wu, L. J., Miyasa, T., Ueno, A., Kuroyanagi, M., Noro, T., Fukushima, S., and Sasaki, S., Studies on the constituents of Sophora flavescens Aiton. II. Chem. Pharm. Bull., 33, 3231- 3236 (1985) 
  23. Squadrito, G. L. and Pryor, W. A., Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide. Free Radical Biol. Med., 25, 392-403 (1998) 
  24. Rice-Evans, C. A., Miller, N., and Paganga, G., Structureantioxidant activity relationships of flavonoids and phenolic acids. Free Ridical Biol. Med., 20, 933-956 (1996) 
  25. Mizuno, M., Iinuma, M., Tanaka, T., Sakakibara, N., Fujikawa, T., Hanioku, S., Ishida, Y., Liu, X. S., and Murata, H., Flavonol glycosides in the roots of Epimedium diphyllum. Phytochemistry, 27, 3645-3647 (1988) 
  26. Kyogoku, K., Hatayama, K., and Komatsu, M., Constituents of Chinese crude drug 'Kushen' (the root of Sophora flavescens Ait.). Isolation of five new flavonoids and formononetin. Chem. Pharm. Bull., 21, 2733-2738 (1973) 
  27. Kuroyanagi, M., Arakawa, T., Hirayama, Y., and Hayashi, T., Antibacterial and antiandrogen flavonoids from Sophora flavescens. J. Nat. Prod., 62, 1595-1599 (1999) 
  28. Woo, E. R., Kwak, J. K., Kim, H. J., and Park, H., A new prenylated flavonol from the roots of Sophora flavescens. J. Nat. Prod., 61, 1595-1599 (1995) 
  29. Kim, J. S., Byun, J. H., Kang, S. S., Son, K. H., Kim, H. P., and Chang, H. W., Isolation of flavonoids and a saponin from Echinosophora koreensis. Kor. J. Pharmacogn., 33, 110-115 (2002) 
  30. Murakoshi, I., Kidoguchi, E., Haginiwa, J., Ohmiya, S., Higashiyama, K., and Otomasu, H., Isokuraramine and (-)- 7,11-dehydromatrine, lupin alkaloids from flowers of Sophora flavescens. Phytochemistry, 21, 2379-2384 (1982) 
  31. Pincemail, J. J., Free radicals and antioxidants in human diseases, In Favier, A. E., Cadet, J., Kalyanaraman, B., Fontecave, M. and Pierre, J. L. (Eds.). Analysis of Free Radicals in Biological System. Birkhauser Verlag, Berlin, pp. 83-98 (1995) 

이 논문을 인용한 문헌 (7)

  1. 2005. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 28(12): 1333~1336 
  2. 2007. "" Natural product sciences, 13(3): 255~257 
  3. 2008. "" Bulletin of the Korean Chemical Society, 29(11): 2287~2290 
  4. 2008. "" Natural product sciences, 14(2): 131~137 
  5. 2010. "" Journal of the Korean Society for Applied Biological Chemistry, 53(5): 626~633 
  6. Choi, Soon-Nam ; Joo, Mi-Kyoung ; Chung, Nam-Yong 2014. "Quality Characteristics of Bread Added with Stevia Leaf Powder" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 30(4): 419~427 
  7. Choi, Young-Sim ; Kim, Sun-Kyung ; Mo, Eun-Kyoung 2014. "Quality characteristics of cookies with acaiberry (Euterpe oleracea Mart.) powder added" 한국식품저장유통학회지 = Korean journal of food preservation, 21(5): 661~667 

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일