[논문]Monoamine Oxidase Inhibitory Naphthoquinones from the Roots of Lithospermum erythrorhizon

Choi Woo Hoi; Hong Seong Su; Lee Seon A; Han Xiang Hua; Lee Kyong Soon; Lee Myung Koo; Hwang Bang Yeon; Ro Jai Seup

doi:10.1007/bf02977668

Monoamine Oxidase Inhibitory Naphthoquinones from the Roots of Lithospermum erythrorhizon 원문보기

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.28 no.4, 2005년, pp.400 - 404

Abstract ▼ AI-Helper

Activity-guided fractionation of a hexane-soluble extract of the roots of Lithospermum erythrorhizon, using a mouse brain monoamine oxidase (MAO) inhibition assay, led to the isolation of two known naphthoquinones, acetylshikonin and shikonin, and a furylhydroquinone, shikonofuran E. These compounds were shown to inhibit MAO with $IC_{50}$ values of 10.0, 13.3, and $59.1 {\mu}M$, respectively. Although no specificity for MAO-A and MAO-B was shown by acetylshikonin and shikonin, a Lineweaver-Burk plot analysis indicated that the inhibition was competitive for both MAO-A and MAO-B activity.

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제안 방법

ESI-MS and EI-MS were measured using a Finnigan Navigator and a Hewlett Packard 5989A mass spectrometer, respectively. Open column chromatography was performed using a silica gel (Kieselgel 60, 70-230 mesh and 230-400 mesh, Merck), and thin layer chromatography (TLC) was performed using a pre-coated silica gel 60 F254 (0.25 mm, Meick).

대상 데이터

The dried roots of L. erythrorhizon were purchased at an herbal diug store in Cheongju, Korea, in April 2003 and identified by Prof. Kyong Soon Lee, a plant taxonomist at Ch니ngbuk National University. A voucher specimen (No.

이론/모형

The MAO activity, with kynuramine as a substrate, was assayed using a modification of Kraml's fluorometric method (Kraml, 1965; Ro et al., 2001). Fluorescence of 4-hydroxyquinoline, which was formed from kynuramine by MAO, was measured at 380 nm with excitation at 315 nm.

참고문헌 (23)

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