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논문 상세정보

Abstract

Activity-guided fractionation of a hexane-soluble extract of the roots of Lithospermum erythrorhizon, using a mouse brain monoamine oxidase (MAO) inhibition assay, led to the isolation of two known naphthoquinones, acetylshikonin and shikonin, and a furylhydroquinone, shikonofuran E. These compounds were shown to inhibit MAO with $IC_{50}$ values of 10.0, 13.3, and $59.1 {\mu}M$, respectively. Although no specificity for MAO-A and MAO-B was shown by acetylshikonin and shikonin, a Lineweaver-Burk plot analysis indicated that the inhibition was competitive for both MAO-A and MAO-B activity.

참고문헌 (23)

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이 논문을 인용한 문헌 (1)

  1. Lee, Hyun-Hwa ; Yoon, Jung-Sik ; Song, Seon-Young 2010. "Protective Effect of Lithospermum erythrorhizon on Galactosamine Induced Liver Injury" 한국현미경학회지 = Korean journal of microscopy, 40(1): 29~35 

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