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논문 상세정보

Abstract

Seven diterpenes, four polyacetylenes, a lipid glycerol, and two sterols were isolated from the methylene chloride fraction of the root of Aralia cordata. Their chemical structures were determined as (-)-pimara-8(14), 15-dien-19-oic acid (2), pimaric acid (3), (-)-kaur-16-en-19-oic acid (4), 17-hydroxy-ent-kaur-15-en-19-oic acid (9), $7{\alpha}$-hydroxy-(-)-pimara-8(14), 15-dien-19-oic acid (10), $16\alpha$, 17 -dihydroxy-(-)-kauran-19-oic acid (11), 16-hydroxy-17-isovaleroyloxy-ent-kauran-19­oic acid (12), falcarindiol (5), dehydrofalcarindiol (6), dehydrofalcarindiol-8-acetate (7), falcarin­diol-8-acetate (8), alpha-mono palmitin (13), stigmasterol (1), and daucosterol (14) by the spectral evidences. These compounds were tested with COX-1 and COX-2 inhibition assays. This study found that compounds 2, 4, 5, 6, 7, 8, and 10 inhibited COX-1 dependent conversion of the exogenous arachidonic acid to $PGE_2$ in a dose-dependent manner with $IC_{50}$ values of $134.2{\mu}M$, $121.6{\mu}M$, $170{\mu}M$, $50.4{\mu}M$, $11.7{\mu}M$, $99.6{\mu}M$, and $69.6{\mu}M$, respectively. But, most of these compounds weakly inhibited COX-2 dependent $PGE_2$ generation. Among them, only compound 4 showed relatively significant inhibitory activity $(IC_{50}\;:\;127.6{\mu}M)$.

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이 논문을 인용한 문헌 (13)

  1. 2006. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 29(7): 548~555 
  2. 2007. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 30(11): 1404~1409 
  3. 2007. "" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, 21(6): 1576~1580 
  4. 2007. "" International journal of oral biology : official journal of the Korean Academy of Oral Biology and the UCLA Dental Research Institute, 32(2): 75~78 
  5. 2008. "" International journal of oral biology : official journal of the Korean Academy of Oral Biology and the UCLA Dental Research Institute, 33(4): 213~216 
  6. Yang, Seun-Ah ; Im, Nam-Kyung ; Jhee, Kwang-Hwan ; Lee, In-Seon 2008. "Effects of Aralia continentalis Kitagawa on Antiplatelet and Antioxidative Activities." 생명과학회지 = Journal of life science, 18(3): 357~362 
  7. 2009. "" Natural product sciences, 15(1): 50~54 
  8. 2009. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 32(10): 1399~1408 
  9. 2009. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 32(9): 1237~1243 
  10. 2009. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 32(6): 923~932 
  11. 2010. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 33(4): 509~514 
  12. Shin, Ye-Ji ; Beak, Yong-Hyeon ; Park, Dong-Suk ; Kim, Jae-Kyu ; Koh, Hyung-Kyun 2010. "The Effect of Aralia Cordata Thunb and Cimicifuga Heracleifolia on Cartilage Protection by the Regulation of Metabolism in Human Osteoarthric Chondrocytes" 大韓鍼灸學會誌= The journal of Korean Acupuncture & Moxibustion Society, 27(4): 39~53 
  13. 2011. "" Journal of the Korean Society for Applied Biological Chemistry, 54(1): 54~58 

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