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The effects of sedative peptide alkaloids from Zizyphus species on calmodulin- dependent protein kinase II were investigated. Protein kinase II activity was assayed on the basis of its ability to activate tryptophan 5-monooxygenase as its substrate in the presence of calmodulin. All thirteen alkaloids tested were stronger inhibitors than chlorpromazine ($IC_50,\;98{\mu}M$) on calmodulin-dependent protein kinase II. Among them, the most potent inhibitor was daechuine S27 ($IC_{50},\;2.95{\mu}M$), which was stronger than pimozide ($IC_{50},\;15.0{\mu}M$).

참고문헌 (24)

  1. Han, B. H., Park, J. H., Park, M. H., Han,Y. N., and Park, M. K., Absolute configuration of sanjoinine A (frangufoline) and its heat induced artifact: sanjoinine-Ah1. Arch. Pharm. Res., 10, 200-201 (1987c) 
  2. Levin, R. M. and Weiss, B., Mechanism by which psychotropic drugs inhibit adenosine cyclic 3,5-monophosphate phosphodiesterase of brain. Mol. Pharmacol., 12, 581-589 (1976) 
  3. Nakada, H. and Fujisawa, H., Purification and properties of tryptophan 5-momooxygenase from rabbit brainstem. Eur. J. Biochem., 122, 41-47 (1982) 
  4. Suh, D.-Y., Kim, Y. C., Han, Y. N., and Han, B. H., Unusual enamide cleavage of frangulfoline under mild acidic condition. Heterocycles, 43, 2347-2361 (1996) 
  5. Friedman, P. A., Kappelman, A. H., and Kaufman, S., Partial purification and characterization of tryptopahn hydroxylase from rabbit bind brain. J. Biol. Chem., 247, 4165-4173 (1972) 
  6. Park, M. K., Park, J. H., Cho, J. H., Park, J. K., Han, Y. N. and Han, B. H., Ionophore activity of fragufoline. Arch. Pharm. Res.,14, 103-104 (1991) 
  7. Han, B. H. and Park, M. H., Alkaloids are the sedative principles of the seeds of Zizyphus vulgaris var. spinosus. Arch. Pharm. Res., 10, 203-207 (1987a) 
  8. Han, B. H. and Park, M. H., Sedative activity and its active components of Zizyphi fructucs. Arch. Pharm. Res., 10, 208- 211 (1987b) 
  9. Fujisawa, H., Yamauchi, T. Nakata, H.,and Okuno, S., Role of calmodulin in neurotransmitter synthesis. In Cheung, W.Y. (ed.). Calcium and Cell Function. Academic press, New York, Vol. V, pp67-99 (1984) 
  10. Yamauchi, T. and Fujisawa, H., Purification and characterization of the brain calmodulin-dependent protein kinase (kinase II), which is involved in the activation of tryptophan 5- monooxygenase. Eur.J.Biochem., 132, 15-21 (1983) 
  11. Kanno, K. and Sasaki, Y., Interaction of psychotropic drugs with phospholipids. Biochem. Pharmacol., 31, 2977-2981 (1982) 
  12. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275 (1951) 
  13. Han, B. H., Park, M. H., and Han, Y. N., Sedative activity of aporphin and cyclopeptide alkaloids isoloated from the seeds of Zizyphus vulgaris var.spinosus, and the fruits and stem bark of Zizyphus jujuba var. inermis in mice.Yakhak Hoeji, 37, 143-148 (1993a) 
  14. Norman, J. A., Drummond, A. H., and Moser, P., Inhibition of calcium-dependent regulator-stimulated phosphodiesterase activity by neuroleptic drugs is unrelated to their clinical efficacy. Mol. Pharmacol., 16, 1089-1094 (1979) 
  15. Tschesche, R. and Kaussmann, E. U., The cyclopeptide alkaloids. The alkaloids. Academic Press, New York, vol. 15, pp165- 205 (1975) 
  16. Levin, R. M. and Weiss, B., selective binding of antipsychotics and other psychoactive agents to the calcium-dependent activator of cyclic nucleotide phosphodiesterase. J. Pharmacol. Exp. Ther., 208, 454-459 (1979) 
  17. Klee, C.B., Crouch, T. H., and Richman, P. G., Calmodulin. Annu. Rev. Biochem.,49, 489-515 (1980) 
  18. Han, B. H., Park, M. H., and Han, Y. N., Cyclic peptide and peptide alkaloids from seeds of Zizyphus vulgaris. Phytochemistry, 29, 3315-3319 (1990) 
  19. Gietzen, K., Mansard, A., and Bader, H., Inhibition of human erythrocyte $Ca^{2+}$-transport ATPase by phenothiazines and butyrophenones. Biochim. Biophys. Res. Commun., 94, 674- 681 (1980) 
  20. Han, B. H., Park, M. H., and Park, J. H., Chemical and pharmacological studies on sedative cyclopeptide alkaloids in some Rhamnaceae plants. Pure Appl.Chem., 61, 443-448 (1989) 
  21. Kuhn, D. M., OCallaghan, J. P., Juskevich, J., and Lovenberg. W., Activation of brain tryptophan hydroxylase by ATP-$Mg^{2+}$: dependence on calmodulin. Pro.Natl. Acad. Sci. U.S.A., 77, 4688-4691 (1980) 
  22. Han, Y. N., Kim, G. -Y., Hwang, K. H., and Han, B. H., Binding of sanjoinine-A (frangufoline) to calmodulin. Arch. Pharm. Res., 16, 289-294 (1993b) 
  23. Han, B. H., Park, M. H., and Han, Y. N., Studies on the sedative alkaloids from Zizyphus spinosus semen. Kor. J. Pharmacogn., 16, 233-238 (1985) 
  24. Hwang, K. H., Han, Y. N., and Han, B. H., Inhibition of calmodulin-dependent calcium ATPase and phosphodi esterase by various cyclopeptides and peptide alkaloids from the Zizyphus species. Arch. Pharm. Res., 24, 202-206 (2001) 

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