$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

The effects of sedative peptide alkaloids from Zizyphus species on calmodulin- dependent protein kinase II were investigated. Protein kinase II activity was assayed on the basis of its ability to activate tryptophan 5-monooxygenase as its substrate in the presence of calmodulin. All thirteen alkaloids tested were stronger inhibitors than chlorpromazine ($IC_50,\;98{\mu}M$) on calmodulin-dependent protein kinase II. Among them, the most potent inhibitor was daechuine S27 ($IC_{50},\;2.95{\mu}M$), which was stronger than pimozide ($IC_{50},\;15.0{\mu}M$).

참고문헌 (24)

  1. Han, B. H., Park, J. H., Park, M. H., Han,Y. N., and Park, M. K., Absolute configuration of sanjoinine A (frangufoline) and its heat induced artifact: sanjoinine-Ah1. Arch. Pharm. Res., 10, 200-201 (1987c) 
  2. Levin, R. M. and Weiss, B., Mechanism by which psychotropic drugs inhibit adenosine cyclic 3,5-monophosphate phosphodiesterase of brain. Mol. Pharmacol., 12, 581-589 (1976) 
  3. Nakada, H. and Fujisawa, H., Purification and properties of tryptophan 5-momooxygenase from rabbit brainstem. Eur. J. Biochem., 122, 41-47 (1982) 
  4. Suh, D.-Y., Kim, Y. C., Han, Y. N., and Han, B. H., Unusual enamide cleavage of frangulfoline under mild acidic condition. Heterocycles, 43, 2347-2361 (1996) 
  5. Friedman, P. A., Kappelman, A. H., and Kaufman, S., Partial purification and characterization of tryptopahn hydroxylase from rabbit bind brain. J. Biol. Chem., 247, 4165-4173 (1972) 
  6. Park, M. K., Park, J. H., Cho, J. H., Park, J. K., Han, Y. N. and Han, B. H., Ionophore activity of fragufoline. Arch. Pharm. Res.,14, 103-104 (1991) 
  7. Han, B. H. and Park, M. H., Alkaloids are the sedative principles of the seeds of Zizyphus vulgaris var. spinosus. Arch. Pharm. Res., 10, 203-207 (1987a) 
  8. Han, B. H. and Park, M. H., Sedative activity and its active components of Zizyphi fructucs. Arch. Pharm. Res., 10, 208- 211 (1987b) 
  9. Fujisawa, H., Yamauchi, T. Nakata, H.,and Okuno, S., Role of calmodulin in neurotransmitter synthesis. In Cheung, W.Y. (ed.). Calcium and Cell Function. Academic press, New York, Vol. V, pp67-99 (1984) 
  10. Yamauchi, T. and Fujisawa, H., Purification and characterization of the brain calmodulin-dependent protein kinase (kinase II), which is involved in the activation of tryptophan 5- monooxygenase. Eur.J.Biochem., 132, 15-21 (1983) 
  11. Kanno, K. and Sasaki, Y., Interaction of psychotropic drugs with phospholipids. Biochem. Pharmacol., 31, 2977-2981 (1982) 
  12. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275 (1951) 
  13. Han, B. H., Park, M. H., and Han, Y. N., Sedative activity of aporphin and cyclopeptide alkaloids isoloated from the seeds of Zizyphus vulgaris var.spinosus, and the fruits and stem bark of Zizyphus jujuba var. inermis in mice.Yakhak Hoeji, 37, 143-148 (1993a) 
  14. Norman, J. A., Drummond, A. H., and Moser, P., Inhibition of calcium-dependent regulator-stimulated phosphodiesterase activity by neuroleptic drugs is unrelated to their clinical efficacy. Mol. Pharmacol., 16, 1089-1094 (1979) 
  15. Tschesche, R. and Kaussmann, E. U., The cyclopeptide alkaloids. The alkaloids. Academic Press, New York, vol. 15, pp165- 205 (1975) 
  16. Levin, R. M. and Weiss, B., selective binding of antipsychotics and other psychoactive agents to the calcium-dependent activator of cyclic nucleotide phosphodiesterase. J. Pharmacol. Exp. Ther., 208, 454-459 (1979) 
  17. Klee, C.B., Crouch, T. H., and Richman, P. G., Calmodulin. Annu. Rev. Biochem.,49, 489-515 (1980) 
  18. Han, B. H., Park, M. H., and Han, Y. N., Cyclic peptide and peptide alkaloids from seeds of Zizyphus vulgaris. Phytochemistry, 29, 3315-3319 (1990) 
  19. Gietzen, K., Mansard, A., and Bader, H., Inhibition of human erythrocyte $Ca^{2+}$-transport ATPase by phenothiazines and butyrophenones. Biochim. Biophys. Res. Commun., 94, 674- 681 (1980) 
  20. Han, B. H., Park, M. H., and Park, J. H., Chemical and pharmacological studies on sedative cyclopeptide alkaloids in some Rhamnaceae plants. Pure Appl.Chem., 61, 443-448 (1989) 
  21. Kuhn, D. M., OCallaghan, J. P., Juskevich, J., and Lovenberg. W., Activation of brain tryptophan hydroxylase by ATP-$Mg^{2+}$: dependence on calmodulin. Pro.Natl. Acad. Sci. U.S.A., 77, 4688-4691 (1980) 
  22. Han, Y. N., Kim, G. -Y., Hwang, K. H., and Han, B. H., Binding of sanjoinine-A (frangufoline) to calmodulin. Arch. Pharm. Res., 16, 289-294 (1993b) 
  23. Han, B. H., Park, M. H., and Han, Y. N., Studies on the sedative alkaloids from Zizyphus spinosus semen. Kor. J. Pharmacogn., 16, 233-238 (1985) 
  24. Hwang, K. H., Han, Y. N., and Han, B. H., Inhibition of calmodulin-dependent calcium ATPase and phosphodi esterase by various cyclopeptides and peptide alkaloids from the Zizyphus species. Arch. Pharm. Res., 24, 202-206 (2001) 

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일