$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

In Vitro Inhibitory Effect of Triterpenoidal Saponins from Platycodi Radix on Pancreatic Lipase 원문보기

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.28 no.2, 2005년, pp.180 - 185  

Xu Bao Jun (Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, The Pharmaceutical Institute, Dalian University) ,  Han Li Kun (Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto) ,  Zheng Yi Nan (College of Chinese Material Medicine, Jilin Agricultural University) ,  Lee Jeong Hyun (Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University) ,  Sung Chang Keun (Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University)

Abstract AI-Helper 아이콘AI-Helper

In the process of investigating anti-obesity effect of Platycodi Radix, we found that aqueous extract of Platycodi Radix might inhibit intestinal absorption of dietary fat by inhibiting pancreatic lipase (PL) activity. In order to clarify the anti-obesity mechanism of Platycodi Radix, activity-guide...

주제어

AI 본문요약
AI-Helper 아이콘 AI-Helper

* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.

데이터처리

  • ). The data were statistically analyzed by one way ANOVA. Fishers Protected LSD and/or Scheffes tests were used to determine the significance of differences among the groups.
본문요약 정보가 도움이 되었나요?

참고문헌 (32)

  1. Arai, I., Komatsu, Y., Hirai, Y., Shingu, K., Ida, Y., Yamaura, H., Yamamoto, T., Kuroiwa, Y., Sasaki, K., and Taguchi, S., Stimulative effects of saponin from kikyo-to, a Japanese herbal medicine, on pancreatic exocrine secretion of conscious rats. Planta Med., 63, 419-424 (1997) 

  2. Bray, G. A., A concise review on the therapeutics of obesity. Nutrition, 16, 953-960 (2000) 

  3. Bray, G. A., The underlying basis for obesity: Relationship to cancer. J. Nutr., 132, 3451S-3455S (2002) 

  4. Choi, S. S., Han, E. J., Lee, T. H., Lee, J. K., Han, K. J., Lee, H. K., and Suh, H. W., Antinociceptive mechanisms of platycodin D administered intracerebroventricularly in the mouse. Planta Med., 68, 794-798 (2002) 

  5. Diego, A. M., Nebojsa, I., Alexander, P., Dawn, L. B., Susan, K. F., and Ilya, R., Inhibitory effects of grape seed extract on lipases. Nutrition, 19, 876-879 (2003) 

  6. Drent, M. L., Larsson, I., William, O. T., Quaade, F., Czubayko, F., Von Bergmann, K., Strobel, W., and Van der veen, E. A., Orlistat (Ro 18-0647), a lipase inhibitor, in the treatment of human obesity: a multiple dose study. Int. J. Obes., 19, 221- 226 (1995a) 

  7. Drent, M. L., Popp, S. C., Ader, H. J., Jansen, J. B., and Van der veen, E. A., Lipase inhibition and hormonal status, body composition and gastrointestinal processing of a lipid high-fat mixed meal in moderately obese subjects. Obes. Res., 3, 573-581 (1995b) 

  8. Flegal, K. M., Carroll, M. D., Ogden, C. L., and Johnson, C. L., Prevalence and trends in obesity among US adults, 1999- 2000. JAMA, 288, 1723-1727 (2002) 

  9. Han, L. K., Xu, B. J., Kimura, Y., Zheng, Y. N., and Okuda, H., Platycodi Radix affects lipid metabolism in mice with high fat dietinduced obesity. J. Nutr., 130, 2760-2764 (2000) 

  10. Han, L. K., Kimura, Y., Kawashima, M., Takaku, T., Taniyama, T., Hayashi, T., Zheng, Y. N., and Okuda, H., Anti-obesity effects in rodents of dietary tea saponin, a lipase inhibitor. Int. J. Obes., 25, 1459-1464 (2001) 

  11. Han, L. K., Zheng, Y. N., Xu, B. J., Okuda, H., and Kimura, Y., Saponins from Platycodi Radix ameliorate high fat dietinduced obesity in mice. J. Nutr., 132, 2241-2245 (2002) 

  12. Hatano, T., Yamashita, A., and Hashimoto, T., Ito, H., Kubo, N., Yoshiyama, M., Shimura, S., Itoh, Y., Okuda, T., and Yoshida, T., Flavin dimers with lipase inhibitory activity from Cassia nomame. Phytochemistry, 46, 893-900 (1997) 

  13. Hernell, O., Straggers, J. E., and Carey, M. C., Physical-chemical behavior analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human being. Biochemistry, 29, 2041-2056 (1990) 

  14. Ishii, H., Tori, K., Tozyo, T., and Yoshimura, Y., Structures of polygalacin-D and - $D_{2}$ , platycodin-D and - $D_{2}$ , and their monoacetaes, saponins isolated from Platycodon grandiflorum, determined by $^{13}C$ -NMR spectroscopy. Chem. Pharm. Bull., 26, 674-677 (1978) 

  15. Ishii, H., Tori, K., Tozyo, T., and Yoshimura, Y., Saponins from roots of Platycodon grandiflorum. Part 2. Isolation and structure of new triterpene glycosides. J. Chem. Soc. Perkin Trans. I., 661-668 (1984) 

  16. Kawano-Takahashi, Y., Ohminami, H., Okuda, H., Kitagawa, I., Yoshikawa, M., Arichi, S., and Hayashi, T., Effect of soya saponins on gold thioglucose (GTG)-induced obese mice. Int. J. Obes., 10, 293-302 (1986) 

  17. Kim, K. S., Ezaki, O., Ikemoto, S., and Itakura, H., Effects of Platycodon grandiflorum feeding on serum and liver lipid concentration in rats with diet induced hyperlipidemia. J. Nutr. Sci. Vitaminol., 41, 485-491 (1995) 

  18. Kim, Y. P., Lee, E. B., Kim, S. Y., Li, D. W., Ban, H. S., Lim, S. S., Shin, K. Y., and Ohuchi, K., Inhibition of prostaglandin $E_{2}$ production by platycodin D isolated from the root of Platycodon grandiforum. Planta Med., 67, 362-364 (2001) 

  19. Kimura, Y., Okuda, H., Arichi, S., and Takemoto, T., Effects of crude saponins of Gynostemma pentaphylium on lipid metabolism. Shoyakugaku Zasshi, 37, 272-275 (1983) 

  20. Kwon C. S., Sohn, H. Y., Kim, S. H., Kim, J. H., Son, K. H., Lee, J. S., Lim, J. K., and Kim, J. S., Anti-obesity effects of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents. Biosci. Biotechnol. Biochem., 67, 1451-1456 (2003) 

  21. Mita, A., Shida, R., Kasai, N., and Shoji, J., Enhancement and suppression in production of IgM-antibody in the mice treated with purified saponins. Biomedicine, 31, 223-227 (1979) 

  22. Saeki, T., Koike, K., and Nikaido, T., A comparative study on commercial, botanical gardens and wild samples of the roots of Platycodon grandiflorum by HPLC analysis. Planta Med., 65, 428-431 (1999) 

  23. Shin, C. Y., Lee, W. J., Lee, E. B., Choi, E. Y., and Ko, K. H., Platycodin D and $D_{3}$ increase airway mucin release in vivo and in vitro in rats and hamsters. 68, 221-225 (2002) 

  24. Tada, A., Kaneiwa, Y., Shoji, J., and Shibata, S., Studies on the saponins from roots of Platycodon grandiflorum A. De Candolle. I. Isolation and the structure of platycodin-D. Chem. Pharm. Bull., 23, 2965-2972 (1975) 

  25. Tsujitu, T. and Okuda, H., Carboxylestrase in rat and human sera and their relationship to serum acylamidases and cholinesterase. Eur. J. Biochem., 135, 215-220 (1983) 

  26. Verger, R. Pancreatic lipase. In Borgstorm, B. and Brockman, H. L., (Eds.). Lipase. Elsevier, Amsterdam, The Netherlands, pp. 83-105, (1984) 

  27. Xu, B. J. Xu, C. L., Cui, M., Liu, M. X., and Zheng, Y. N., Identification on saponins composition of Platycodon grandiflorum applied mass spectral analyses method. J. Jilin Agricultural University, 21, 35-41 (1999) 

  28. Xu, B. J., Zheng, Y. N., Cui, M., and Song, F. R., Identification of platycodin-D by electrospray mass spectrum. Chinese J. Med. Chem., 10, 193-196 (2000) 

  29. Xu, B. J., Zheng, Y. N., and Sung, C. K., Quality control and evaluation of Platycodon grandiflorum: Implication for future management. Nat. Prod. Sci., 10(4), 141-151 (2004) 

  30. Yamamoto, M., Shimura, S., Itoh, Y., Ohsaka, T., Egawa, M., and Inoue, S., Anti-obesity effects of lipase inhibitor CT-II, an extract from edible herbs, Nomame herba, on rats fed a highfat diet. Int. J. Obes. Relat. Metab. Disord., 24, 758-764 (2000) 

  31. Yoshikawa, M., Shimoda, H., Nishida, N., Takada, M., and Matsuda, H., Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats. J. Nutr., 132, 1819-1824 (2002) 

  32. Zapf, J., Schoenle, E., Waldvoge, M., Sand, M., and Foresch, E. R., Effects of trypsin treatment of rat adipocyte on biological effects and binding of insulin and insulin-like growth factors: further evidence for the action of insulin-like growth factors through the insulin receptor. Eur. J. Biochem., 133, 605-609 (1981) 

저자의 다른 논문 :

관련 콘텐츠

오픈액세스(OA) 유형

FREE

Free Access. 출판사/학술단체 등이 허락한 무료 공개 사이트를 통해 자유로운 이용이 가능한 논문

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로