$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

In the process of investigating anti-obesity effect of Platycodi Radix, we found that aqueous extract of Platycodi Radix might inhibit intestinal absorption of dietary fat by inhibiting pancreatic lipase (PL) activity. In order to clarify the anti-obesity mechanism of Platycodi Radix, activity-guided isolation was performed to find active components. The total saponin fraction of Platycodi Radix appeared to have a potent inhibitory activity against the hydrolysis of triolein emulsified with phosphatidycholine by pancreatic lipase in vitro. Based on these results, further purification of active components yielded 10 known triterpenoidal saponins, among these compounds, platycodin A, C, D, and deapioplatycodin D exhibited significant inhibitory effects on PL at the concentration of $500\;{\mu}g/mL$ with 3.3, 5.2, 34.8, and $11.67\%$ pancreatic lipase activity vs control, respectively. Platycodin D was found to inhibit the PL activity in a dose-dependent manner. Therefore, the anti-obesity effect of Platycodi Radix might be due to the inhibition of pancreatic lipase by its saponins.

참고문헌 (32)

  1. Choi, S. S., Han, E. J., Lee, T. H., Lee, J. K., Han, K. J., Lee, H. K., and Suh, H. W., Antinociceptive mechanisms of platycodin D administered intracerebroventricularly in the mouse. Planta Med., 68, 794-798 (2002) 
  2. Drent, M. L., Larsson, I., William, O. T., Quaade, F., Czubayko, F., Von Bergmann, K., Strobel, W., and Van der veen, E. A., Orlistat (Ro 18-0647), a lipase inhibitor, in the treatment of human obesity: a multiple dose study. Int. J. Obes., 19, 221- 226 (1995a) 
  3. Kim, Y. P., Lee, E. B., Kim, S. Y., Li, D. W., Ban, H. S., Lim, S. S., Shin, K. Y., and Ohuchi, K., Inhibition of prostaglandin $E_{2}$ production by platycodin D isolated from the root of Platycodon grandiforum. Planta Med., 67, 362-364 (2001) 
  4. Kwon C. S., Sohn, H. Y., Kim, S. H., Kim, J. H., Son, K. H., Lee, J. S., Lim, J. K., and Kim, J. S., Anti-obesity effects of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents. Biosci. Biotechnol. Biochem., 67, 1451-1456 (2003) 
  5. Mita, A., Shida, R., Kasai, N., and Shoji, J., Enhancement and suppression in production of IgM-antibody in the mice treated with purified saponins. Biomedicine, 31, 223-227 (1979) 
  6. Verger, R. Pancreatic lipase. In Borgstorm, B. and Brockman, H. L., (Eds.). Lipase. Elsevier, Amsterdam, The Netherlands, pp. 83-105, (1984) 
  7. Flegal, K. M., Carroll, M. D., Ogden, C. L., and Johnson, C. L., Prevalence and trends in obesity among US adults, 1999- 2000. JAMA, 288, 1723-1727 (2002) 
  8. Kim, K. S., Ezaki, O., Ikemoto, S., and Itakura, H., Effects of Platycodon grandiflorum feeding on serum and liver lipid concentration in rats with diet induced hyperlipidemia. J. Nutr. Sci. Vitaminol., 41, 485-491 (1995) 
  9. Shin, C. Y., Lee, W. J., Lee, E. B., Choi, E. Y., and Ko, K. H., Platycodin D and $D_{3}$ increase airway mucin release in vivo and in vitro in rats and hamsters. 68, 221-225 (2002) 
  10. Xu, B. J., Zheng, Y. N., Cui, M., and Song, F. R., Identification of platycodin-D by electrospray mass spectrum. Chinese J. Med. Chem., 10, 193-196 (2000) 
  11. Han, L. K., Kimura, Y., Kawashima, M., Takaku, T., Taniyama, T., Hayashi, T., Zheng, Y. N., and Okuda, H., Anti-obesity effects in rodents of dietary tea saponin, a lipase inhibitor. Int. J. Obes., 25, 1459-1464 (2001) 
  12. Tada, A., Kaneiwa, Y., Shoji, J., and Shibata, S., Studies on the saponins from roots of Platycodon grandiflorum A. De Candolle. I. Isolation and the structure of platycodin-D. Chem. Pharm. Bull., 23, 2965-2972 (1975) 
  13. Han, L. K., Xu, B. J., Kimura, Y., Zheng, Y. N., and Okuda, H., Platycodi Radix affects lipid metabolism in mice with high fat dietinduced obesity. J. Nutr., 130, 2760-2764 (2000) 
  14. Arai, I., Komatsu, Y., Hirai, Y., Shingu, K., Ida, Y., Yamaura, H., Yamamoto, T., Kuroiwa, Y., Sasaki, K., and Taguchi, S., Stimulative effects of saponin from kikyo-to, a Japanese herbal medicine, on pancreatic exocrine secretion of conscious rats. Planta Med., 63, 419-424 (1997) 
  15. Hernell, O., Straggers, J. E., and Carey, M. C., Physical-chemical behavior analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human being. Biochemistry, 29, 2041-2056 (1990) 
  16. Bray, G. A., The underlying basis for obesity: Relationship to cancer. J. Nutr., 132, 3451S-3455S (2002) 
  17. Kimura, Y., Okuda, H., Arichi, S., and Takemoto, T., Effects of crude saponins of Gynostemma pentaphylium on lipid metabolism. Shoyakugaku Zasshi, 37, 272-275 (1983) 
  18. Drent, M. L., Popp, S. C., Ader, H. J., Jansen, J. B., and Van der veen, E. A., Lipase inhibition and hormonal status, body composition and gastrointestinal processing of a lipid high-fat mixed meal in moderately obese subjects. Obes. Res., 3, 573-581 (1995b) 
  19. Zapf, J., Schoenle, E., Waldvoge, M., Sand, M., and Foresch, E. R., Effects of trypsin treatment of rat adipocyte on biological effects and binding of insulin and insulin-like growth factors: further evidence for the action of insulin-like growth factors through the insulin receptor. Eur. J. Biochem., 133, 605-609 (1981) 
  20. Yamamoto, M., Shimura, S., Itoh, Y., Ohsaka, T., Egawa, M., and Inoue, S., Anti-obesity effects of lipase inhibitor CT-II, an extract from edible herbs, Nomame herba, on rats fed a highfat diet. Int. J. Obes. Relat. Metab. Disord., 24, 758-764 (2000) 
  21. Yoshikawa, M., Shimoda, H., Nishida, N., Takada, M., and Matsuda, H., Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats. J. Nutr., 132, 1819-1824 (2002) 
  22. Diego, A. M., Nebojsa, I., Alexander, P., Dawn, L. B., Susan, K. F., and Ilya, R., Inhibitory effects of grape seed extract on lipases. Nutrition, 19, 876-879 (2003) 
  23. Tsujitu, T. and Okuda, H., Carboxylestrase in rat and human sera and their relationship to serum acylamidases and cholinesterase. Eur. J. Biochem., 135, 215-220 (1983) 
  24. Han, L. K., Zheng, Y. N., Xu, B. J., Okuda, H., and Kimura, Y., Saponins from Platycodi Radix ameliorate high fat dietinduced obesity in mice. J. Nutr., 132, 2241-2245 (2002) 
  25. Hatano, T., Yamashita, A., and Hashimoto, T., Ito, H., Kubo, N., Yoshiyama, M., Shimura, S., Itoh, Y., Okuda, T., and Yoshida, T., Flavin dimers with lipase inhibitory activity from Cassia nomame. Phytochemistry, 46, 893-900 (1997) 
  26. Bray, G. A., A concise review on the therapeutics of obesity. Nutrition, 16, 953-960 (2000) 
  27. Saeki, T., Koike, K., and Nikaido, T., A comparative study on commercial, botanical gardens and wild samples of the roots of Platycodon grandiflorum by HPLC analysis. Planta Med., 65, 428-431 (1999) 
  28. Xu, B. J. Xu, C. L., Cui, M., Liu, M. X., and Zheng, Y. N., Identification on saponins composition of Platycodon grandiflorum applied mass spectral analyses method. J. Jilin Agricultural University, 21, 35-41 (1999) 
  29. Xu, B. J., Zheng, Y. N., and Sung, C. K., Quality control and evaluation of Platycodon grandiflorum: Implication for future management. Nat. Prod. Sci., 10(4), 141-151 (2004) 
  30. Ishii, H., Tori, K., Tozyo, T., and Yoshimura, Y., Structures of polygalacin-D and -$D_{2}$, platycodin-D and -$D_{2}$, and their monoacetaes, saponins isolated from Platycodon grandiflorum, determined by $^{13}C$-NMR spectroscopy. Chem. Pharm. Bull., 26, 674-677 (1978) 
  31. Kawano-Takahashi, Y., Ohminami, H., Okuda, H., Kitagawa, I., Yoshikawa, M., Arichi, S., and Hayashi, T., Effect of soya saponins on gold thioglucose (GTG)-induced obese mice. Int. J. Obes., 10, 293-302 (1986) 
  32. Ishii, H., Tori, K., Tozyo, T., and Yoshimura, Y., Saponins from roots of Platycodon grandiflorum. Part 2. Isolation and structure of new triterpene glycosides. J. Chem. Soc. Perkin Trans. I., 661-668 (1984) 

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일