[논문]육계에서의 플로르페니콜 및 그의 대사체인 플로르페니콜 아민의 약물동태학적 연구

박병권; 임종환; 김명석; 황윤환; 윤효인

육계에서의 플로르페니콜 및 그의 대사체인 플로르페니콜 아민의 약물동태학적 연구
Pharmacokinetics of Florfenicol and its Metabolite, Florfenicol Amine, in Broiler Chickens 원문보기

Journal of veterinary clinics = 한국임상수의학회지, v.23 no.2 = no.53, 2006년, pp.114 - 118

박병권 (충남대학교 수의과대학) , 임종환 (비앤씨바이오팜) , 김명석 (충남대학교 수의과대학) , 황윤환 (충남대학교 수의과대학) , 윤효인 (충남대학교 수의과대학)

초록
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본 연구는 플로르페니콜을 체중당 20mg 용량으로 경구 및 정맥내로 투여한 후 플로르페니콜 및 그 대사체인 플로르페니콜 아민의 생체이용율 및 약물동태학적 분석을 육계에서 실시하였다. 혈청내의 플로르페니콜 및 플로르페니콜 아민의 정량은 액체크로마토그래프/질량분석기를 사용하였으며, 경구 및 정맥내 투여후 혈청 농도-시간 자료는 non-compartmental analysis를 이용하여 분석하였다. 플로르페니콜의 정맥주사 후 청소율 및 소실반감기는 각각 $0.74{\pm}0.25L/kg/h$와 $1.15{\pm}1.06h$로 나타났으며, 정상상태 분포용적은 $1.16{\pm}0.19L/kg$으로 정맥주사후 빠른 체내 분포와 소실을 나타냈다. 플로르페니콜의 경구투여 후 혈중최고농도 ($8.18{\pm}0.97{\mu}g/mL$)는 $1.33{\pm}0.29h$에 나타났다. 소실반감기는 $1.24{\pm}0.64h$이었으며, 경구생체이용율은 약 75.46%로 나타났다. 플로르페니콜의 주요 대사체인 플로르페니콜 아민은 정맥 및 경구투여한 모든 육계에서 검출되었다. 플로르페니콜 아민의 혈중최고농도는 정맥 및 경구투여 후 각각 $1.88{\pm}0.39{\mu}g/mL$과 $2.64{\pm}1.39{\mu}g/mL$로 $0.16{\pm}0.19h$ 및 $1.61{\pm}1.02h$에 관찰되었다. 플로르페니콜 아민은 정맥 및 경구 투여후 각각 $1.88{\pm}0.39$ and $2.64{\pm}1.39h$로 그 모약인 플로프페니콜보다 다소 느리게 소실되었다.

Abstract ▼ AI-Helper

A study on bioavailability and pharmacokinetics of florfenicol was conducted in broilers following a single intravenous (i.v.) and oral (p.o.) doses of 20 mg/kg body weight (b.w.). Florfenicol concentrations in plasma were determined by a high-performance liquid chromatography/mass spectrometry. Plasma concentration-time data after i.v. administration were analyzed by a non-compartmental analysis. Following i.v. injection, the total body clearance was $0.74{\pm}0.25L/kg/h$ and the volume of distribution at steady-state was $1.16{\pm}0.19L/kg$. Florfenicol was rapidly distributed and eliminated following i.v. injection with $1.15{\pm}1.06h$ of elimination half-life. After oral administration, the calculated $C_{max}$ values ($8.18{\pm}0.97{\mu}g/mL$) were reached at $1.33{\pm}0.29h$ in broilers. The elimination half-life of florfenicol was $1.31{\pm}0.27h$ and the absolute bioavailability (F) was 75.46% after oral administration of florfenicol. Florfenicol amine, a major metabolite of florfenicol, was detected in all broilers after i.v. and p.o. administration of florfenicol. The observed $C_{max}$ values of florfenicol amine ($3.96{\pm}2.60\;and\;2.22{\pm}1.71{\mu}g/mL$) were reached at $0.16{\pm}0.19\;and\;1.61{\pm}1.02h$ after i.v. and p.o. administration of florfenicol, respectively. Florfenicol amine was eliminated with $1.88{\pm}0.39\;and\;2.64{\pm}1.39h$ of the elimination half-life after i.v. and p.o. administration of florfenicol, respectively.

주제어

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문제 정의

Florfenicol amine is the longest-lived major metabolite in the liver and this was therefore used as the marker residue for withdrawal calculation (19). The aim of this study was to evaluate plasma disposition of florfenicol and its major metabolite, florfenicol amine, after intravenous (i.v.) and oral (p.o.) administrations in broilers.

대상 데이터

Twenty male broiler chickens (1.59±0.25 kg) were obtained from a commercial farm in Korea. Before the experiment, the animals were acclimatized for 1 week.

데이터처리

Lambda z is a first-order rate constant associated with the terminal (log linear) segment of the curve. It was estimated by linear regression of the terminal data points. The terminal elimination half-life (t|/2^) was calculated by t1/2Zz=:0.

이론/모형

The data analysis was performed by the non-compartmental analysis using a combined linear trapezoidal rule approach (WinNonlin 4.1, Pharsight, USA). Lambda z is a first-order rate constant associated with the terminal (log linear) segment of the curve.

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