In this paper, mesoporous Pt on micro pillars Pt electrode is newly designed, fabricated, and characterized on silicon substrate for non-enzymatic electrochemical sensor micro-chip integrated with CMOS readout circuitry. The fabricated micro/nano Pt electrode has cylindrical hexangular arrayed nano ...
In this paper, mesoporous Pt on micro pillars Pt electrode is newly designed, fabricated, and characterized on silicon substrate for non-enzymatic electrochemical sensor micro-chip integrated with CMOS readout circuitry. The fabricated micro/nano Pt electrode has cylindrical hexangular arrayed nano Pt pores with a diameter of 3.2 nm which is formed on top of the micro pillars Pt electrode with approximately $6{\mu}m$ in diameter, $6{\mu}m$ in space, and $50{\mu}m$ in height. The measured current responses of the fabricated plane Pt, mesoporous Pt, and mesoporous Pt on the micro pillar Pt electrodes are approximately $9.9nA/mm^2,\;6.72{\mu}A/mm^2,\;and\;7.67{\mu}A/mm^2$ in 10mM glucose solution with 0.1M phosphate buffered saline (PBS) solution, respectively. In addition, the measured current responses of the fabricated plane Pt, mesoporous Pt, and mesoporous Pt on the micro pillar Pt electrodes are approximately $0.15{\mu}A/mm^2,\;0.56{\mu}A/mm^2,\;and\;0.74{\mu}A/mm^2$ in 0.1mM ascorbic acid (AA) solution with 0.1M phosphate buffered saline (PBS) solution, respectively. This experimental results show that the proposed micro/nano Pt electrode is highly sensitive and promising for CMOS integrated non-enzymatic electrochemical sensor applications. Since the micro-pillar Pt electrode can also be utilized with a micro-fluidic mixer in the sensor chip, the sensor chip can be much smaller, cheaper, and easier to be fabricated.
In this paper, mesoporous Pt on micro pillars Pt electrode is newly designed, fabricated, and characterized on silicon substrate for non-enzymatic electrochemical sensor micro-chip integrated with CMOS readout circuitry. The fabricated micro/nano Pt electrode has cylindrical hexangular arrayed nano Pt pores with a diameter of 3.2 nm which is formed on top of the micro pillars Pt electrode with approximately $6{\mu}m$ in diameter, $6{\mu}m$ in space, and $50{\mu}m$ in height. The measured current responses of the fabricated plane Pt, mesoporous Pt, and mesoporous Pt on the micro pillar Pt electrodes are approximately $9.9nA/mm^2,\;6.72{\mu}A/mm^2,\;and\;7.67{\mu}A/mm^2$ in 10mM glucose solution with 0.1M phosphate buffered saline (PBS) solution, respectively. In addition, the measured current responses of the fabricated plane Pt, mesoporous Pt, and mesoporous Pt on the micro pillar Pt electrodes are approximately $0.15{\mu}A/mm^2,\;0.56{\mu}A/mm^2,\;and\;0.74{\mu}A/mm^2$ in 0.1mM ascorbic acid (AA) solution with 0.1M phosphate buffered saline (PBS) solution, respectively. This experimental results show that the proposed micro/nano Pt electrode is highly sensitive and promising for CMOS integrated non-enzymatic electrochemical sensor applications. Since the micro-pillar Pt electrode can also be utilized with a micro-fluidic mixer in the sensor chip, the sensor chip can be much smaller, cheaper, and easier to be fabricated.
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가설 설정
The mesoporous (nanopores with sizes of 2 nm ~50 nm) platinum formed on a bulky Pt rod was reported for non-enzymatic glucose sensor applications . [2] Glucose was very sensitively reacted in the mesoporous Pt working electrode, due to the extremely expanded surface activation area of the working electrode. In addition, ascorbic acid (AA) and acetaminophen (AP) in human blood are much less sensitively reacted than the glucose.
제안 방법
All electrochemical measurements were performed in three electrodes system by using an electrochemical analyzer (CH Instruments Inc., USA) and an Ag/AgCl electrode and a plane Pt electrode were used as a reference electrode and a counter electrode, respectively.
이론/모형
3 shows cyclic v이tammetry in 2M sulfuric acid solution of the fabricated micro and nano Pt electrodes. This experiment was performed to clean the surface and to activate the electrodes by using hydrogen adsorption/desorption methods [6]. The current response of the mesoporous Pt on the micro pillar Pt electrode is larger than the other Pt electrodes.
성능/효과
The measured current responses were also large enough to analyze the chemical substances without any enzymes. And also, the experimental results in AA and AP elution showed that the strong potential of the fabricated mesoporous Pt on the micro pillar Pt electrode for non-enzymatic glucose sensor chip integrated with CMOS circuitry. Bio chips can also be miniaturized, simplified, and easily febricated by utilizing the micro pillar electrode as the mixer of the bio chips.
참고문헌 (7)
Wen-Tso Liu and Liang Zhu, 'Environmental microbiology-on-a-chip and its future impacts,' TRENDS in Biotechnology, vol. 23 (4), pp. 174-179, April 2005
S. J. Park, T. D. Chung and H. C. Kim, 'Nonenzymatic glucose detection using mesoporous platinum,' Anal. Chem. United States, vol. 75, pp. 3046-3049, July 2003
S. Park, H. Boo and T. D. Chung, 'Elecrochemical non-enzymatic glucose sensors,' Anal. Chim. Acta., vol. 556, pp. 46-57, 2006
G. S. Attard, P. N. Bartlett, N. R. B. Coleman, J. M. Elliott, J. R. Owen and J. H. Wang, 'Mesoporous platinum films from lyotropic liquid crystalline phases,' Science. United States, vol. 278, pp. 838-840, October 1997
H. K. Seo and J. Y. Park, 'Nano-Fabricated Mesoporous Pt electrode on Silicon for CMOS Integrated Electrochemical Sensor Applications', IEEE NEMS 2006
H. Boo, S. Park, B. Ku, Y. Kim, J. H. Park, H. C. Kim and T. D. Chung, 'Ionic strength-controlled virtual area of mesoporous platinum electrode,' J. Am. Chem. Soc. United States, vol. 126, pp. 4524-4525, March 2004
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