한약제는 사람의 많은 질병의 치료를 위하여 사용되어 왔으나, 개 안면신경마비에 대한 한약제의 치료 효과는 현재까지 검토된 바 없다. 개 안면신경마비에 대한 오약순기산의 치료 효과를 조사하였다. 인공적으로 안면신경마비를 유발한 총 10두 대조군(5두)과 한약제 치료군(5두,오약순기산 치료군)으로 나누어 공시하였다. 대조군은 아무런 처치를 하지 않았으며,오약순기산 치료군은 1일 2회, 총 2주간 오약순기산(50 mg/kg)을 경구 투여하였다. 오약순기산 치료군의 임상 지표는 대조군에 비하여 14일(p<0.05)에 유의성 있는 개선을 보였다. 오약순기산 치료군의 혈청 CK 활성 변화는 대조군에 비하여 낮은 경향을 나타냈지만 유의성은 인정되지 않았다. 결론적으로, 오약순기산은 개 안면신경마비 치료에 유효한 것으로 판단되었다.
한약제는 사람의 많은 질병의 치료를 위하여 사용되어 왔으나, 개 안면신경마비에 대한 한약제의 치료 효과는 현재까지 검토된 바 없다. 개 안면신경마비에 대한 오약순기산의 치료 효과를 조사하였다. 인공적으로 안면신경마비를 유발한 총 10두 대조군(5두)과 한약제 치료군(5두,오약순기산 치료군)으로 나누어 공시하였다. 대조군은 아무런 처치를 하지 않았으며,오약순기산 치료군은 1일 2회, 총 2주간 오약순기산(50 mg/kg)을 경구 투여하였다. 오약순기산 치료군의 임상 지표는 대조군에 비하여 14일(p<0.05)에 유의성 있는 개선을 보였다. 오약순기산 치료군의 혈청 CK 활성 변화는 대조군에 비하여 낮은 경향을 나타냈지만 유의성은 인정되지 않았다. 결론적으로, 오약순기산은 개 안면신경마비 치료에 유효한 것으로 판단되었다.
Herbal medicines are widely used to treat a variety of human diseases. However, therapeutic effect of herbal medicine on the canine facial nerve paralysis (FNP) has not been investigated. This study examined therapeutic effects of Oyaksungisan on the canine FNP. Ten dogs with the induced canine FNP ...
Herbal medicines are widely used to treat a variety of human diseases. However, therapeutic effect of herbal medicine on the canine facial nerve paralysis (FNP) has not been investigated. This study examined therapeutic effects of Oyaksungisan on the canine FNP. Ten dogs with the induced canine FNP were equally divided into the control and an herbal medicine-treated groups (5 dogs, Oyaksungisan-treated group), respectively. No treatment was given to the control group. In the Oyaksungisan-treated group, Oyaksungisan was administered orally, twice per day for 2 weeks (50 mg/kg) after inducing FNP. Significant differences in the clinical scores were detected between the Oyaksungisan-treated and control groups on day 14 (p < 0.05). The serum creatine kinase (CK) activities in the Oyaksungisan-treated group showed a tendency to decrease but there was no significant difference compared with those of the control group. In conclusion, Oyaksungisan was effective for the induced canine FNP.
Herbal medicines are widely used to treat a variety of human diseases. However, therapeutic effect of herbal medicine on the canine facial nerve paralysis (FNP) has not been investigated. This study examined therapeutic effects of Oyaksungisan on the canine FNP. Ten dogs with the induced canine FNP were equally divided into the control and an herbal medicine-treated groups (5 dogs, Oyaksungisan-treated group), respectively. No treatment was given to the control group. In the Oyaksungisan-treated group, Oyaksungisan was administered orally, twice per day for 2 weeks (50 mg/kg) after inducing FNP. Significant differences in the clinical scores were detected between the Oyaksungisan-treated and control groups on day 14 (p < 0.05). The serum creatine kinase (CK) activities in the Oyaksungisan-treated group showed a tendency to decrease but there was no significant difference compared with those of the control group. In conclusion, Oyaksungisan was effective for the induced canine FNP.
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문제 정의
This study investigated the therapeutic effect of Oyaksungisan on canine FNP. The results showed improvement in clinical symptoms, and a significant diffirence was detected between the Oyaksungisan-treated and control groups.
대상 데이터
A total of 10 clinically healthy mongrel dogs (2 to 3 years old, 2.0 to 5.6 kg BW) were used in this study. The experimental dogs were fed commercial dog food (Sun-Jung Co.
이론/모형
, Korea) for 2 weeks before the experiment. This study was performed in accordance to the rules of the Ethics Committee for Experimental Animals, Chungnam National University.
성능/효과
In conclusion, Oyaksungisan was effective for treatment of the induced canine FNP.
The results showed improvement in clinical symptoms, and a significant diffirence was detected between the Oyaksungisan-treated and control groups. Regarding the changes of serum CK activities, the Oyaksunkisan-treated group showed a tendency to decrease, compared with those of the control group but no significant difference was detected.
on canine FNP. The results showed improvement in clinical symptoms, and a significant diffirence was detected between the Oyaksungisan-treated and control groups. Regarding the changes of serum CK activities, the Oyaksunkisan-treated group showed a tendency to decrease, compared with those of the control group but no significant difference was detected.
후속연구
(9) examined the therapeutic effect of an injection-AP with apitoxin and dexamethasone at LI04, LI20, ST02, ST07, TH 17, SI18, GB03 and GB34, twice/week for 2 weeks, and reported that the apitoxin and dexamethasone groups showed significantly different clinical scores and serum CK activities than those of the control group. In this study therapeutic effect of Oyaksungisan for treatment of canine FNP was investigated, however, more precise researches about herbal medicines combined by AP therapy 아K)uld be performed in the future.
참고문헌 (20)
Braund KG, Luttgen PJ, Sorjonen DC, Redding RW. Idiopathic facial paralysis in the dog. Vet Rec 1979; 105: 297-299
Gu R, Liu RY, Zhang LJ, Hao XY, Xiao Y, Qi XL, Shan KR, Ren XL, Luo J, Guan ZZ. Protection of Tianshen Yizhi Recipe against low expression of nicotinic receptor and neurotoxicity induced by beta-amyloid peptide. Zhong Xi Yi Jie He Xue Bao 2007 5: 564-569
Ha JY, Lee SG, Yu BG. Effects of Oyaksunkisan acuaacupuncture on adjuvant arthritis in rats. Kor J Orien Med Pathol 2000; 14: 144-154
Hwang JH, Lee DG, Lee HJ, Cho HS, Kim KH, Kim KS. Effect of combined silver spike point therapy and electroacupuncture on patient with peripheral facial paralysis. J Kor Acup & Mox 2007; 24: 70-80
Hwang YJ, Lee H, Heo YK, Song HG, Ahn TW, Hwang JO. Comparison studies on 20 cases of Bell's palsy patients by acupuncture and rainbow therapy and acupuncture. J Kor Acup & Mox 2006; 15: 87-95
Jeong SM, Kim HY, Lee CH, Kweon OK, Nam TC. Use of acupuncture for the treatment of idiopathic facial nerve paralysis in a dog. Vet Rec 2001; 19: 632-633
Jun HK, Oh HU, Han JW, Lee HH, Jeong SM, Choi SH, Kim MH, Kim DH. Therapeutic effect of bee-venom and dexamethasone in dogs with facial nerve paralysis. J Vet Clin 2007; 24: 503-508
Kern TJ, Erb HN. Facial neuropathy in dogs and cat: 95 cases (1975-1985). J Am Vet Med Assoc 1987; 191: 1604-1609
Kim HT, Kim JW, Jin TW, Kim JE, Lim MK, Yeo SG, Jang KH, Oh TH, Lee KW. Effects of blood biochemistry and tumor`s weight of Artemisia capillaries methanol extract in mice bearing cancer cells. J Vet Clin 2007; 24: 372-378
Kim TK, Kim SH, Jun HK, Yoon HI, Cho SW, Kim DH. Recovery effect of Xiao Chai Hu Tang (So Si Ho Tang) on the hepatic injury in dogs. J Vet Clin 2007; 24: 164-168
Kim Y, So HS, Kim JK, Park C, Lee JH, Woo WH, Cho KH, Moon BS and Park R. Anti-inflammatory effect of Oyaksungisan in peripheral blood mononuclear cells from cerebral infarction patients. Biol Pharm Bull 2007; 30: 1037-1041
Moon YH, Lee DI and Lee SY. Studies on the antiinflammatory and analgesicactivities of Ohyaksungisan. Kor J Pharmacogn 1996; 27: 184-189
Schoen AM. Acupuncture for neurological disorder. In: Veterinary Acupuncture, 1st ed. St. Louis: Mosby, 1994:171-180
Seul KY, Yun YM, Kim BS, Choi GC, Lee KK. The therapeutic effect of Oldenlandiae Herbaand Houttuynia Cordata on calf diarrhea. J Vet Clin 2007; 24: 529-536
Shafshak TF. The treatment of facial palsy from the point of view of physical and rehabilitation medicine. Eura Medicophys 2006; 42: 41-47
Shi J, Tong Y, Shen JG, Li HX. Effectiveness and safety of herbal medicines in the treatment of irritable bowel syndrome: A systematic review. World J Gastroenterol 2008 21: 454-462
Shin JY. Oyaksungisan. In: Bang Yak Hap Pyun Hae Seol, 7th ed., Seongnam city: Seongbosa2005: 101-102
Tveintnes D, Oymar K, Natas O. Acute facial nerve palsy in children: How oftenis it lyme borreliosis?. Scand J Infect Dis 2007; 39: 425-431
Wang WJ, Wu ZK, Zhang XH, Liu YM, Fang SP, Wang RX, Zhang C, Li PP, Luo RG. Clinical observation of Yisui Shengxue Granule in treating 25 patients with hemoglobin H disease. Zhong Xi Yi Jie He Xue Bao 2008 6: 153-156
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