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작약(芍藥)의 성분연구(成分硏究) (1);Monoterpene glucoside의 분리
Phytochemical Studies on Paeoniae Radix (1);Monoterpene Glucosides 원문보기

생약학회지, v.39 no.1 = no.152, 2008년, pp.19 - 27  

연민혜 (서울대학교 약학대학, 천연물과학연구소) ,  이주영 (서울대학교 약학대학, 천연물과학연구소) ,  김주선 (서울대학교 약학대학, 천연물과학연구소) ,  강삼식 (서울대학교 약학대학, 천연물과학연구소)

Abstract AI-Helper 아이콘AI-Helper

From the polar fractions of 70% EtOH extract of Paeonia lactiflora roots (Paeoniaceae), ten monoterpene glucosides were isolated and identified as lactiflorin (1), benzoylpaeoniflorin (2), mudanpioside C (3), $1-O-{\beta}-D-glucosylpaeonisuffrone$ (4), paeonidanin (5), $1-O-{\beta}-D...

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문제 정의

  • 본 연구는 식품의약품안전청 과제인 한약재 평가기술과학화연구사업중 “한약재 생리활성성분 분리 및 효능 유전자 확인연구: 작약, 황기” 과제의 일환으로 수행되었다. 또한 BK21 사업에 의해 일부 지원되었으며 이에 감사드린다.
  • 따라서 이런 추세를 반영하기 위하여서는 정확한 작약의 기원식물에 대한 화학적, 약리학적 연구결과가 토대가 되어야 한다. 이를 위하여 한약재 평가기술과학화 연구를 위한 사업이 진행 중에 있으며 본 연구도 그 사업의 일환으로 수행된바 그 연구 결과를 보고하고자 한다.
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참고문헌 (61)

  1. 배기환 (2000) 한국의 약용식물, 168. 교학사, 서울 

  2. Wei, W.-S., Wang, Y.-Q. and Wang, S.-Y. (1987) Immunoregulatory effects of total glucosides of paeony root in mice. Chin. Pharmacol. Bull. 3: 148-152 

  3. Yamahara, J., Yamada, T., Kimura, H., Sawada, T. and Fujimura, H. (1982) Biologically active principles of crude drugs. II. Anti-allergic principles in 'Shosejryu-To' antiinflammatory properties of paeoniflorin and its derivatives. J. Pharmaco-Dynamics 5: 921-929 

  4. Ohta, H., Matsumoto, K., Watanabe, H. and Shimizu, M. (1993) Involvement of beta-adrenergic systems in the antagonizing effect of paeoniflorin on the scoploamine-induced deficit in renal maze performance in rats. Jpn. J. Pharmacal. 62: 345-349 

  5. Ohta, H., Ni, J.-W., Matsumoto, K., Watanabe, H. and Shimizu, M. (1993) Peony and its major constituent, Paeoniflorin, improve radial maze performance impaired by scopolamine in rats. Pharmacol. Biochem. Behav. 45: 719-723 

  6. Ohta, H., Matsumoto, K., Shimizu, M. and Watanabe, H. (1994) Paeoniflorin attenuates learning impairment of aged rats in operant brightness discrimination task. Pharmacol. Biochem. Behav. 49: 213-217 

  7. Watanabe, H. (1997) Candidates for cognitive enhancer extracted from medicinal plants: paeoniflorin and tetramethylpyrazine. Behav. Brain Res. 83: 135-141 

  8. He, X. H., Xing, D. M., Ding, Y., Li, Y. P., Xu, L. Z. and Du, L. J. (2004) Effects of cerebral ischemia-reperfusion on pharmacokinetic fate of paeoniflom after intravenous adminstration of Paeoniae Radix extract in rats. J. Ethnopharmacol. 94: 339-344 

  9. Ye, J., Duan, H., Yang, X., Yan, W. and Zheng, X. (2001) Anti-thrombosis effect of paeoniflorin: evaluated in a photochemical reaction thrombosis model in vivo. Planta Med. 67: 766-767 

  10. Hsu, F. L., Lai, C. W. and Cheng, J. T. (1997) Antihy-perglycemic effects of paeoniflorin and 8-debenzoylpaeon-iflorin, glucosides from the root of Paeonia lactiflora. Planta Med. 63: 323-325 

  11. Ishida, H., Takamatsu, M., Tsuji, K. and Kosuge, T. (1987) Studies on active substances in herbs used for Oketsu ('Stagnant Blood') in Chinese Medicine. VI. On the anticoagulative principle in Paeoniae Radix. Chern. Pharm. Bull. 35: 849-852 

  12. Tsai, H.-Y., Lin, Y.-T., Tsai, C.-H. and Chen, Y.-F. (2001) Effects of paeoniflorin on the formalin-induced nociceptive behaviour in mice. J. Ethnopharmacol. 75: 267-271 

  13. Yang, H. O., Ko, W. K., Kim, J. Y. and Ro, H. S. (2004) Paeoniflorin: an antihyperlipidemic agent from Paeonia lactiflora. Fitoterapia 75: 45-49 

  14. Abdel-Hafez, A. A., Meselhy, M. R., Nakamura, N., Hattori, M., Watanabe, H., Murakami, Y., El-Gendy, M. A., Mahfouz, N. M. and Mohamed, T. A. (1998) Effects of paeoniflorin derivatives on scopolamine-induced amnesia using a passive avoidance task in mice; structure-activity relationship. Biol. Pharm. Bull. 21: 1174-1179 

  15. Abdel-Hafez, A. A., Meselhy, M. R., Nakamura, N., Hattori, M., Watanabe, H., Mohamed, T. A., Mahfouz, N. M. and El-Gendy, M. A. (1998) Potent anticonvalsant paeonimetabolinI derivatives obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis. Chem. Pharm. Bull. 46: 1486-1487 

  16. Abdel-Hafez, A. A., Meselhy, M. R., Nakamura, N., Hattori, M., Watanabe, H., Murakami, Y., El-Gendy, M. A., Mahfouz, N. M. and Mohamed, T. A. (1999) Anticonvalsant activity of paeonimetabolin-I adducts obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis. Biol. Pharm. Bull. 22: 491-497 

  17. Liu, T. P., Liu, M., Tsai, C. C., Lai, T. Y., Hsu, F. L. and Cheng, J. T. (2002) Stimulatory effect of paeoniflorin on the release of noradrenaline from ileal synaptosomes of gineapig in vitro. J. Pharm. Pharmacol. 54: 81-88 

  18. Dezaki, K., Kimura, I., Miyahara, K. and Kimura, M. (1995) Complementary effects of paeoniflorin and glycyrrhizin on intracellular $Ca^{2+}$ mobilization in the nerve-stimulated skeletal muscle of mice. Jpn. J. Pharmacol. 69: 281-284 

  19. Sakai, Y., Nagase, H., Ose, Y., Kito, H., Sata, T., Kawai, M. and Mizuno, M. (1990) Inhibitory action of peony root extract on the mutagenicity of benzo[a]pyrene. Mutat. Res. Lett. 244: 129-134 

  20. Kobayashi, M., Ueda, C., Aoki, S., Tajima, K., Tanaka, N. and Yamahara, J. (1990) Anticholinergic action of Paeony Root and its active constituents. Yakugaku Zasshi 110: 964-968 

  21. Tsuboi, H., Hossain, K., Akhand, A. A., Takeda, K., Du, J., Rifa'i, M., Dai, Y., Hayakawa, A., Suzuki, H. and Nakashima, I. (2004) Paeoniflorin induces apoptosis of lymphocytes through a redox-linked mechanism. J. Cell Biochem. 93: 162-172 

  22. Lai, C.-W., Hsu, F.-L. and Cheng, J.-T. (1998) Stimulatory effect of paeoniflorin on adenosine A-1 receptors to increase the translocation of protein kinase C (PKC) and glucose transporter (GLUT 4) in isolated rat white adipocytes. Life Sci. 62: 1591-1595 

  23. Tabata, K., Matsumoto, K., Murakami, Y. and Watanabe (2001) Ameliorative effects of paeoniflorin, a major constituent of Peony Root, on adenosine $A_1$ receptor-mediated impairment ofpassive aviodance performance and long-term potentiation in the hippocampus. BioI. Pharm. Bull. 24: 496-500 

  24. Lee, S. M. Y., Li, M. L. Y., Tse, Y. C., Leung, S. C. L., Lee, M. M. S., Tsui, S. K. A., Fung, K. P., Lee, C. Y. and Waye, M. M. Y. (2002) Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. Life Sci. 71: 2267-2277 

  25. Zhang, G.-Q., Hao, X.-M., Chen, S.-Z., Zhou, P.-A., Cheng, H.-P. and Wu, C.-H. (2003) Blockade of paeoniflorin on sodium current in mouse hippocampal $CA_1$ neurons. Acta Pharmacol. Sin. 24: 1248-1252 

  26. Yan, D., Saito, K., Ohmi, Y., Fujie, N. and Ohtsyka, K. (2004) Paeoniflorin, a novel heat shock protein-inducing compound. Cell Stress Chaperones 9: 378-389 

  27. Okubo, T., Nagai, F., Seto, T., Satoh, K., Ushiyama, K. and Kano, I. (2000) The inhibition of phenylhydroquinoneinduced oxidative DNA cleavage by constituents of Moutan Cortex and Paeoniae Radix. BioI. Pharm. Bull. 23: 199-203 

  28. Liu, D.-Z., Zhao, F.-L., Liu, J., Ji, X.-Q., Ye, Y. and Zhu, X.-Z. (2006) Potentiation of adenosine $A_1$ receptor agonist CPA-induced antinociception by paeoniflorin in mice. BioI. Pharm. Bull. 29: 1630-1633 

  29. Liu, D.-F., Wei, W. and Song, L.-H. (2006) Protective effect of paeoniflorin on immunological liver injury induced by Bacillus calmette-guerin plus lipopolysaccharide: Modulation of tumor necrosis $factor-{\alpha}$ and interleukin-6 mRNA. Clin. Exp. Pharmcol. Physiol. 33: 332-339 

  30. Murakami, N., Saka, M., Shimada, H., Matsuda, H., Yamahara, J. and Yoshikawa, M. (1996) New bioactive monoterpene glycosides from Paeoniae Radix. Chem. Pharm. Bull. 44: 1279-1281 

  31. Institute for Production Development Science (1983) 'Paeonone' Jpn Kokai Tokkyo Koho JP 58-18,398 pp. 949-954 [CA 99: 16561p (1983)] 

  32. Yen, P. H., Kiem, P. V., Nhiem, N. X., Tung, N. H., Quang, T. H., Minh, C. V., Kim, J. W, Choi, E. M. and Kim Y. H. (2007) A new monoterpene glycoside from the roots of Paeonia lactiflora increases the differentiation of osteoblastic MC3T3-E1 cells. Arch. Pharm. Res. 30: 1179-1185 

  33. Wang, H., Wei, W., Wang, N.-P., Wu, C.-Y., Yan, S.-X., Yue, L., Zhang, L.-L. and Xu, S.-Y. (2005) Effects of total glucosides of peony on immunological hepatic fibrosis in rats. World J. Gastroenterol. 11: 2124-2129 

  34. Zheng, Y.-Q. and Wei, W. (2005) Total glycosides ofpaeony suppresses adjuvant arthritis in rats and intervenes cytokinesignaling between different types of synoviocytes. Int. Immunopharmacol. 5: 1560-1573 

  35. Zhu, L., Wei, W., Zheng, Y.-Q. and Jia, X.-Y. (2005) Effects and mechanisms of total glucosides of paeony on joint damage in rat collagen-induced arthritis. Injlamm. Res. 54: 211-220 

  36. Hong, J.-A, Chung, S.-H., Lee, J.-S., Kim, S.-S., Shin, H.D., Kim, H., Jang, M.-H., Lee, T.-H., Lim, B.-V., Kim, Y.-P. and Kim, C.-J. (2003) Effects of Paeonia Radix on 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats. BioI. Pharm. Bull. 26: 166-169 

  37. Yu, Y.-B., Jeong, I.-Y., Park, H.-R., Oh, H., Jung, U. and Jo, S.-K. (2004) Toxicological safety and stability of the components of an irradiated Korean medicinal herb, Paeoniae Radix. Rad. Phys. Chem. 71: 115-119 

  38. Leem, K., Kim, H., Boo, Y., Lee, H. S., Kim, J. S., Yoo, Y. C., Ahn, H. J., Park, H. J., Seo, J. C., Kim, H. K., Jin, S. Y., Park, H. K., Chung, J. H. and Cho, J. J. (2004) Effects of Paeonia lactiflora root extracts on the secretions of monocyte chemotactic Protein-1 and -3 in human nasal fibroblasts. Phytother. Res. 18: 241-243 

  39. Shibata, S., Aimi, N. and Watanabe, M. (1964) Paeoniflorin, a monoterpene glucoside of Chinese Paeony Root. Tetrahedron Lett. 5: 1991-1995 

  40. Aimi, N., Inaba, M., Watanabe, M. and Shibata, S. (1969) Chemical studies on the oriental plant drugs - XXIII. Paeoniflorin, a glucoside of Chinese Paeony Root. Tetrahedron 25: 1825-1838 

  41. Kaneda, M., Iitaka, Y. and Shibata, S. (1972) Chemical studies on the oriental plant drugs - XXXIII. The absolute structures ofpaeoniflorin, albiflorin, oxypaeoniflorin and benzoyIpaeoniflorin isolated from Chinese Paeony Root. Tetrahedron 28: 4309-4317 

  42. Yamasaki, K., Kaneda, M. and Tanaka, O. (1976) Carbon-13 nmr spectral assignments of paeoniflorin homologues with the aid of spin-lattice relaxation time. Tetrahedron Lett. 17: 3965-3968 

  43. Lang, H. Y. Li, S. Z., McCabe, T. and Clardy, J. (1984) A new monoterpene glycoside of Paeonia lactiflora. Planta Med. 50: 501-504 

  44. Yang, H. Y., Li, S. Z., Wang, H. B., Yu, D. Q. and Liang, X. T. (1990) The structure of lactiflorin, an artefact during isolation? Tetrahedron 46: 323-3128 

  45. Yu, J., Elix, J. and Iskander, M. N. (1990) Lactiflorin, A monoterpene glycoside from Paeony Root. Phytochemistry 29: 3859-3863 

  46. Zhang, X.-Y., Gao, C.-K, Wang, J.-H. and Li, X. (2002) A new monoterpene glycoside from Paeonia lactiflora Pall. Acta Pharm. Sin. 37: 705-708 

  47. Kang, S. S., Shin, K. H. and Chi, H. J. (1989) Galloylpaeoniflorin, A new monoterpene glucoside from Paeony Roots. Kor. J. Pharmacogn. 20: 48-49 

  48. Kang, S. S., Shin, K. H. and Chi, H. J. (1991) Galloylpaeoniflorin, A new acylated monoterpene glucoside from Paeony Root. Arch. Pharm. Res. 14: 52-54 

  49. http://kfda.go.kr 

  50. Lemmich, J. (1996) Monoterpene and coumarin glucosides of Cnidium silaifolium. Phytochemistry 41: 1337-1340 

  51. Mitova, M., Passov, St. and Handjieva, N. (1999) Paeoniflorin from Galium aegeum. Fitoterapia 70: 109-110 

  52. Kitagawa, I., Yoshikawa, M., Tsunaga, K. and Tani, T. (1979) Studies on Moutan Cortex (II) On the chemical constituents. Shoyalatgalat Zasshi 33: 171-177 

  53. Lin, H.-C., Ding, H.-Y., Wu, T.-S. and Wu, P.-L. (1996) Monoterpene glycosides from Paeonia suffruticosa. Phytochemistry 41: 237-242 

  54. Yoshikawa, M., Harada, E., Kawaguchi, A Yamahara, J., Murakami, N. and Kitagawa, I. (1993) Absolute stereostructures of paeonisuffrone and paeonisuffral, two new labile monoterpenes, from Chinese Moutan Cortex. Chem. Pharm. Bull., 41: 630-632 

  55. Yoshikawa, M., Ohta, T., Kawaguchi, A. and Matsuda, H. (2000) Bioactive constituents of Chinese natural medicines. V. Radical scavenging effect ofMoutan Cortex. (1): Absolute stereostructures of two monoterpenes. paeonisuffrone and paeonisuffral. Chern. Pharm. Bull., 48: 1327-1331 

  56. Kasai, R., Suzuo, M., Asakawa, 1.-1. and Tanaka, O. (1977) Carbon-13 chemical shifts of $isoprenoid-{\beta}-D-glucopyrano-sides$ and $-{\beta}-D-mannopyranosides$ . Stereochemical influences of aglycone alcohols. Tetrahedron Lett. 18: 175-178 

  57. Kim, J. S., Yean, M. H., Lee, J. Y., Kim, Y. J., Lee, E. J., Lee, S. Y. and Kang, S. S. (2008) A new monoterpene glucoside from the roots of Paeonia lactiflora. Helv. Chim. Acta 91: 101-105 

  58. Kostava, I. N., Simeonov, M. F. and Todorova, D. I. (1998) A monoterpene glucoside from Paeonia peregrina roots. Phytochemistry 47: 1303-1307 

  59. Kostava, I. N., Simeonov, M. F., Todorova, D. I. and Petkova, P. L. (1998) Two acylated monoterpene glucosides from Paeonia peregrina. Phytochemistry 48: 511-514 

  60. Kritsanida, M., Magiatis, P., Skaltsounis, A.-L. and Stables, J. P. (2006) Phytochemical investigation and anticonvulsant activity of Paeonia parnassica Radix. Nat. Prod Commun. 2: 351-356 

  61. Yoo, M. Y., Lee, B. H., Choi, Y. H., Lee, J. W., Seo, J. H., Oh, K.-S., Koo, H.-N., Seo, H. W., Yon, G H., Kwon, D. Y., Kim, Y. S. and Ryu, S. Y. (2006) Vasorelaxant effect of the rootbark extract of Paeonia moutan on isolated rat thoracic aorta. Planta Med. 72: 1338-1341 

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