[논문]알코올 급여 흰쥐의 혈중 성호르몬 및 아연 농도에 미치는 아연 고함유 효모 Saccharomyces cerevisiae 급여의 영향

차재영; 허진선; 박보경; 조영수

doi:10.5352/jls.2008.18.7.947

알코올 급여 흰쥐의 혈중 성호르몬 및 아연 농도에 미치는 아연 고함유 효모 Saccharomyces cerevisiae 급여의 영향
Effect of Zinc-Enriched Yeast Supplementation on Serum Zinc and Testosterone Concentrations in Ethanol Feeding Rats 원문보기

생명과학회지 = Journal of life science, v.18 no.7 = no.99, 2008년, pp.947 - 951

차재영 (대선주조(주) 기술연구소) , 허진선 (동아대학교 생명자원과학대학 생명공학과) , 박보경 (동아대학교 생명자원과학대학 생명공학과) , 조영수 (동아대학교 생명자원과학대학 생명공학과)

초록
AI-Helper

아연은 많은 생리학적인 기능을 가지는 필수미량 원소로, 특히 성기능에 있어서 중요한 역할을 하는 것으로 잘 알려져 있다. 열대 과일 Rambutan으로부터 분리된 아연 고함유 효모의 미네랄 성분은 아연 306 ppm, K 28,640 ppm, Mg 2,342, Na 1,048 ppm, Ca 366 ppm, Fe 236 ppm 및 Mn 4 ppm이 함유되어 있었다. 혈청 중 성호르몬인 테스토스테론(testosterone) 농도는 정상군에 비해 에탄올 급여 실험군에서 감소 경향을 나타내었다. 에탄올 급여에 의한 성호르몬 테스토스테론의 농도 감소는 아연 고함유 효모 투여로 현저하게 증가하였다. 또한, 혈청 중 아연 함량에 에탄올 급여 실험군에서 감소경향을 보였고, 이러한 감소는 아연 고함유 효모 투여로 현저하게 증가하였다. 따라서, 에탄올 투여에 의한 혈중 아연 및 테스토스테론 농도의 감소효과는 아연 고함유 효모 투여로 상쇄되는 것으로 나타나 본 실험에 사용된 아연 고함유 효모는 성기능 관련 건강기능식품의 소재로서 산업적으로 유용하게 사용될 것으로 사료되어 진다.

Abstract ▼ AI-Helper

Zinc is an essential trace element participating in many physiological functions and notably an important function for sperm physiology. Zinc-enriched yeast strain, Saccharomyces cerevisiae, isolated from tropical fruit rambutan. This strain contained 306 ppm zinc concentration and other components contained by K 28,640 ppm, Mg 2,342 ppm, Na 1,048 ppm, Ca 366 ppm, Fe 236 ppm and Mn 4 ppm. The serum concentration of testosterone was decreased in ethanol treatment rats. As compared with ethanol treated control rats, the zinc-enriched yeast strain supplementation showed significantly increased the testosterone concentration in serum. In addition, zinc concentration in serum was decreased in alcohol treatment, but this reduction was significantly increased by zinc-enriched yeast strain supplementation in ethanol feeding rats. These results indicate that zinc-enriched yeast Saccharomyces cerevisiae strain could play an important role in the sperm physiology by the marked elevation of serum testosterone concentration.

주제어

AI 본문요약
AI-Helper

* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.

문제 정의

cerevisiae was isolated from the juice of the rambutan fruit [5]. Thus, the objective of this study was to investigate whether the administration of the zinc-enriched yeast S. cerevisiae causes an increase of serum testosterone concentration in ethanol feeding rats.

제안 방법

Animals were allowed to access frely to semi-purified basal diet for 1 week before the experiment. Animals were then randomly divided into three experimental groups based on dietary categories: the normal rats fed with water and tesal diet, the ethanol control rats fed with ethanol and basal diet; ethanoHyeast feeding rats fed with ethanol and 5% (w/w) zinc-enriched yeast strain contained basal diet. A normal diet consisting of (% by wt) casein 20, com 아arch 15, sucrose 55z cellulose 5, com oil 10, AIN 93 G-MX mineral mix (MP Biomedicals, Germany) 3.

대상 데이터

Spiague-Dawley strain male rats were purchased from the Hyochang Science Animals Co. (Daegu, Korea) and was housed individually in the suspended wire-mesh stainless steel cage under r(x>m temperature (21 ~24ºC) and lighting (12 hr). Animals were allowed to access frely to semi-purified basal diet for 1 week before the experiment.

데이터처리

The data from animal experiments are presented as the mean+S.E.z and were analyzed using one way analysis of variance (ANOVA\ with the differences analyzed using the Duncan's new multiple-range test [10]. A p value <0.

이론/모형

Total testosterone analyses in the serum were conducted using the commercial test Immulite (Catalogue no: L2KTT2) in accordance with competitive immunoassay method in Neodin Medicinal Institute (Seoul, Korea). The results were shown as μg/L

참고문헌 (39)

Al-Qarawi, A., A. H. Abdel-Rahman, M. S. El-Belely and S. A. El-Mougy. 2000. Age-related changes in plasma testosterone concentrations and genital organs content of bulk and trace elements in the male dromedary camel. Animal Reproduction Sci. 62, 297-307.

상세보기
Assadi, F. K. and M. Ziai. 1986. Zinc status of infants with fetal alcohol syndrome. Pediatric Research 20, 551-554.

상세보기
Baltaci, A. K., R. Mogulkoc and A. Ozturk. 2006. Testosterone and zinc supplementation in castrated rats: Effects on plasma leptin levels and relation with LH, FSH and testosterone. Life Sci. 78, 746-752.

상세보기
Cha, J. Y., J. S. Heo and Y. S. Cho. 2008. Effect of zinc-enriched yeast FF-10 strain on the alcoholic hepatotoxicity in alcohol feeding rats. Food Sci. Biotechnol. (in press).
Cha, J. Y., J. S. Heo, J. W. Kim, S. W. Lee and Y. S. Cho. 2008. Isolation and identification of zinc-enriched yeast Saccharomyces cerevisiae FF-10 from the tropical fruit rambutan. J. Life Sci. 18, 447-457.

원문보기 상세보기
Choi, H. T., S. K. Rhee and J. Y. Son. 2001. Studies on the processing of yeast extract by waste brewery yeast. Korean J. Food Nutr. 14, 161-166
Coudray, C., J. C. Tressol, C. Feillet-Coudray, J. Bellanger, D. Pepin and A. Mazur. 2000. Long-term consumption of red wine does not modify intestinal absorption or status of zinc and copper in rats. J. Nutr. 130, 1309-1313.

상세보기
Diaz-Gomez, N. M., E. Domenech, F. Barroso, S. Castells, C. Cortabarria and A. Jimenez. 2003. The effect of zinc supplementation on linear growth, body composition, and growth factors in preterm infants. Pediatrics 111, 1002-1009

상세보기
Dinsmore, W., M. E. Callender, D. McMaster, S. J. Todd and A. H. Love. 1985. Zinc absorption in alcoholics using zinc-65. Digestion 32, 238-242.

상세보기
Duncan, D. B. 1957. Multiple range test for correlated and heteroscedastic means. Biometrics 13, 164-176.

상세보기
Elless, M., M. Blaylock, J. Huang and C. Gussman. 2000. Plants as a natural source of concentrated mineral nutritional supplements. Food Chem. 71, 181-188.

상세보기
George, A. Z., S. R. Efthymia, G. T. Demetrius and A. S. John. 2002. Determination of mineral content of active dry yeast used in pharmaceutical formulations. J. Pharm. Biomedical Analysis 28, 463-473.

상세보기
Goel, A., V. Dani and D. K. Dhawan. 2005. Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos-induced toxicity. Chem. Biol. Interact 156, 131-140.

상세보기
Hambidge, M. 2000. Human zinc deficiency. J. Nutr. 130 (Suppl), 1345-1349.
Hinesly, T. D., V. Sudarski-hack, D. E. Alexander, E. L. Ziegler and G. L. Barrett. 1977. Effect of sewage sluge applications on phosphorous and metal concentrations in fractions of corn and wheat kernels. Cereal Chem. 56, 283-287.
Kang, G. D., K. H. Lee, S. G. Do, C. S. Kim, J. G. Suh, Y. S. Oh and J. H. Nham. 2001. Effect of silk fibroin on the protection of alcoholic hepatotoxicity in the liver of alcohol preference mouse. Int. J. Indust. Entomol. 2, 15-18.
Krebs, N. F. 2000. Overview of zinc absorption and excretion in the human gastrointestinal tract. J. Nutr. 130, 1374S-1377S.

상세보기
Kumar, N., R. P. Verma, L. P. Singh, V. P. Varshney and R. S. Dass. 2006. Effect of different levels and sources of zinc supplementation on quantitative and qualitative semen attributes and serum testosterone level in crossbred cattle (Bos indicus x Bas Taurus) bulls. Reprod. Nutr. Dev. 46, 663-675.

상세보기
Mertz, W. 1986. Zinc in Trace Elements in Human and Animal Nutrition. New York. Academic press.
Motoi, H. and Y. Suzuki. 2004. A water-soluble natural zinc source prepared from defatted wheat germ. Food Sci. Biotechnol. 13, 17-20.

상세보기
Murillo-fuentes, M. L., R. Artillo, M. L. Ojeda, M. J. Delgado, M. L. Murillo and D. O. Carreras. 2007. Effects of prenatal or postnatal ethanol consumption on zinc intestinal absorption and excretion in rats. Alcohol Alcoholism 42, 3-10.

상세보기
Ohtake, Y. and Y. Okumura. 1992. Establishing a high glutathione producing yeast species. Biosci. Ind. 50, 29-34.
Park, J. C., M. Ok, J. Y. Cha and Y. S. Cho. 2003. Isolation and identification of the glutathione producing Saccharomyces cerevisiae FF-8 from Korean traditional rice wine and optimal producing conditions. J. Korean Soc. Agric. Chem. Biotechnol. 46, 348-352.
Prasad, A. S. 1985. Clinical and biochemical manifestations of zinc deficiency in human subjects. J. Am. Coll. Nutr. 4, 65-72.

상세보기
Prasad, A. S. 1991. Discovery of human zinc deficiency and studies in an experimental human model. Am. J. Clin. Nutr. 53, 403-412.

상세보기
Rabinovich, M., D. Figlas, S. Delmastro and N. Curvetto. 2007. Copper- and zinc-enriched mycelium of Agaricus blazei Murrill: Bioaccumulation and bioavailability. J. Med. Food 10, 175-183.

상세보기
Rana, S., D. Bisht and P. K. Chokraborti. 1998. Activation of rat androgen receptor by androgenic ligands is unaffected by antiandrogens in Saccharomyces cerevisiae. Gene 209, 247-254.

상세보기
Rodriguez, M. F., R. E. Gonzalez, F. F. Santolaria, M. L. Galindo, T. O. Hernandez, L. N. Batista and P. M. Molina. 1997. Zinc, copper, manganese, and iron in chronic alcoholic liver disease. Alcohol 14, 39-44.

상세보기
Shon, M. H., J. Y. Cha, C. H. Lee, S. H. Park and Y. S. Cho. 2007. Protective effect of administrated glutathione- enriched Saccharomyces cerevisiae FF-8 against carbon tetrachloride (CCl4)-induced hepatotoxicity and oxidative stress in rats. Food Sci. Biotechnol. 16, 967-974.

원문보기 상세보기
Strouhal, M., R. Kizek, J. Vacek, L. Trnkova and M. Nemec. 2003. Electrochemical study of heavy metals and metallothionein in yeast Yarrowia lipolytica. Bioelectrochemistry 60, 29-36.

상세보기
Tachiyashiki, K. and K. Imaizumi. 1994. Effects of dried yeast on the body weight, serum cholesterol levels, and perirenal and periepididymal adipose tissue cells in rats. J. Jpn. Sco. Nutr. Food Sci. 47, 219-226.

상세보기
Take, A., K. Yano, Y. Suzuki and K. Noda. 1997. Magnesium, manganese, zinc and copper contents in Japanese foodstuffs. J. Jpn. Soc. Nutr. Food Sci. 30, 381-393.
Tallman, D. L. and C. G. Taylor. 2003. Effects of dietary fat and zinc on adiposity, serum leptin and adipose fatty acid composition in C57BL/6J mice. J. Nutr. Biochem. 14, 17-23.

상세보기
Vallee, B. L. and K. H. Falchuk. 1993. The biochemical basis of zinc physiology. Physiological Review 73, 79-118

상세보기
Vlckova, V., S. Nadova, V. Duhova, K. Zavodan, Z. Moranova, P. Rauko, G. Kogan and E. Miadokova. 2006. Natural microbial polysaccharide sulphoethyl glucan as antigenotoxic and cancer preventing agent. Neoplasma 53, 524-529.

상세보기
Wilson, F. A. and A. W. Hoyumpa. 1979. Ethanol and small intestinal transport. Gastroenterology 76, 388-403.

상세보기
Wilson, P. and H. Greene. 2003. Importance of zinc in human nutrition. Nutr. MD 2, 1-8.
Yasue, M. 2003. Brewer's yeast may prevent obesity. Bioindustry 20, 38-43.
Zachariadis, G. A., E. S. Raidou, D. G. Themelis and J. A. Stratis. 2002. Determination of mineral content of active dry yeast used in pharmaceutical formulations. J. Pharm. Biomed. Anal. 28, 463-473.

상세보기

저자의 다른 논문 :

LOADING...

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증