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NTIS 바로가기한국식품과학회지 = Korean journal of food science and technology, v.41 no.2 = no.204, 2009년, pp.220 - 224
박세정 (순천향대학교 의료과학대학 의료과학과) , 양승주 (건양대학교 임상병리학과) , 윤형선 (순천향대학교 의료과학대학 의료과학과)
Toll-like receptors(TLRs) are pattern recognition receptors(PRRs) that recognize pathogen-associated molecular patterns(PAMPs) and regulate the activation of innate immunity. All TLR signaling pathways culminate in the activation of NF-
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핵심어 | 질문 | 논문에서 추출한 답변 |
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감초는 무엇을 치료하는데 사용되어 왔는가? | 약방의 감초라는 말이 있듯이, 감초는 한약재에 널리 사용되어 왔다. 감초는 오랫동안 음식, 음료수, 담배 등의 맛을 내는 성분으로 사용되었으며, 또한 위궤양(gastric ulcers), 십이지장 궤양(duodenal ulcers), 후두염(sore throats), 감기(coughs), 기관지염(bronchitis), 관절염(arthritis), 부신병(adrenal insufficiency), 그리고 알러지(allergies) 등의 치료에 사용되었다(1-4). 감초는 의학적으로 효과를 가지고 있는 glycyrrhizin, glabridin, 그리고 isoliquiritigenin과 같은 성분들을 포함하고 있다고 많은 연구에 의해서 알려졌다(5-7). | |
감초는 어떻게 사용되어왔는가? | 약방의 감초라는 말이 있듯이, 감초는 한약재에 널리 사용되어 왔다. 감초는 오랫동안 음식, 음료수, 담배 등의 맛을 내는 성분으로 사용되었으며, 또한 위궤양(gastric ulcers), 십이지장 궤양(duodenal ulcers), 후두염(sore throats), 감기(coughs), 기관지염(bronchitis), 관절염(arthritis), 부신병(adrenal insufficiency), 그리고 알러지(allergies) 등의 치료에 사용되었다(1-4). 감초는 의학적으로 효과를 가지고 있는 glycyrrhizin, glabridin, 그리고 isoliquiritigenin과 같은 성분들을 포함하고 있다고 많은 연구에 의해서 알려졌다(5-7). | |
isoliquiritigenin의 항염증 효과는? | 1)은 vasorelaxant(8), anti-platelet aggregation(9) 그리고 anti-allergic activity(10)를 가지고 있다. 또한 ILG는 RAW 264.7 cells에서 LPS(TLR4 ago nist)에 의해서 유도된 inducible nitric oxide(iNOS)와 cyclooxygenase-2(COX-2)의 발현을 억제하여 항염증 효과를 가지고 있다(2). |
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Vogel SN, Fitzgerald KA, Fenton MJ. TLRs: Differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 3: 466-477 (2003)
Kawai T, Akira S. Toll-like receptor and RIG-I-like receptor signaling. Ann. NY Acad. Sci. 1143: 1-20 (2008)
Harris RE, Beebe-Donk J, Doss H, Burr Doss D. Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: A critical review of non-selective COX-2 blockade (review). Oncol. Rep. 13: 559-583 (2005)
Naesdal J, Brown K. NSAID-associated adverse effects and acid control aids to prevent them: A review of current treatment options. Drug Safety 29: 119-132 (2006)
Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 3: 768-780 (2003)
Youn HS, Saitoh SI, Miyake K, Hwang DH. Inhibition of homodimerization of Toll-like receptor 4 by curcumin. Biochem. Pharmacol. 72: 62-69 (2006)
Youn HS, Lee JY, Fitzgerald KA, Young HA, Akira S, Hwang DH. Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex. J. Immunol. 175: 3339-3346(2005)
Youn HS, Lee JY, Saitoh SI, Miyake K, Kang KW, Choi YJ,Hwang DH. Suppression of MyD88- and TRIF-dependent signaling pathways of Toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea. Biochem. Pharmacol. 72: 850-859 (2006)
Youn HS, Lee JY, Saitoh SI, Miyake K, Hwang DH. Auranofin,as an anti-rheumatic gold compound, suppresses LPS-induced homodimerization of TLR4. Biochem. Bioph. Res. Co. 350: 866-871 (2006)
Dinkova-Kostova AT, Massiah MA, Bozak RE, Hicks RJ, Talalay P. Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. P. Natl. Acad. Sci. USA 98: 3404-3409(2001)
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Rungeler P, Castro V, Mora G, Goren N, Vichnewski W, Pahl HL, Merfort I, Schmidt TJ. Inhibition of transcription factor NFkappaB by sesquiterpene lactones: A proposed molecular mechanism of action. Bioorg. Med. Chem. 7: 2343-2352 (1999)
Garcia-Pineres AJ, Castro V, Mora G, Schmidt TJ, Strunck E, Pahl HL, Merfort I. Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones. J. Biol. Chem. 276: 39713-39720 (2001)
Youn HS, Lee JK, Choi YJ, Saitoh SI, Miyake K, Hwang DH, Lee JY. Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. Biochem.Pharmacol. 75: 494-502 (2008)
Kumar S, Sharma A, Madan B, Singhal V, Ghosh B. Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells. Biochem. Pharmacol. 73: 1602-1612(2007)
Meylan E, Burns K, Hofmann K, Blancheteau V, Martinon F, Kelliher M, Tschopp J. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappaB activation. Nat. Immunol. 5: 503-507 (2004)
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