$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

고지방식이 유도 비만쥐에서 아연 수준이 다량 무기질 함량에 미치는 영향

The Macro Mineral Contents in High Fat Diet-Induced Obese Rats Fed Various Amounts of Zinc

초록

본 연구에서는 비만에서 아연 공급수준이 다량 무기질 함량에 미치는 영향을 알아보기 위해 고지방식이로 유도된 비만쥐를 대상으로 아연 요구량의 50%(결핍군), 100%(적정군), 200%(과잉군) 수준으로 공급한 후 혈청 및 조직의 칼슘, 마그네슘, 나트륨 및 칼륨의 함량을 분석하였다. 비만쥐에서 아연 결핍군은 적정군에 비해 혈청의 나트륨, 칼륨 및 비장의 마그네슘, 칼륨 함량이 높았고, 간의 나트륨 함량이 낮았으며, 아연 과잉군은 적정군에 비해 간의 칼슘 함량이 높았다. 이와 같이 아연의 결핍과 과잉 시 비만쥐에서는 혈청과 간, 비장 등이 조직 내 다량 무기질의 함량 변화를 초래했으며, 특히 아연 결핍이 더 많은 조직 내 무기질 함량에 변화를 가져왔다. 따라서 비만에 있어서 아연의 적절한 섭취에 대한 중요성이 강조되어야 할 것으로 보이며, 앞으로 대사적 기전을 규명할 수 있는 지속적인 연구가 요구된다.

Abstract

This study was conducted to investigate the effect of dietary zinc on macro mineral contents of high fat diet-induced obese rats. The obese group was divided into three groups by zinc levels of diet, such as low (50% requirement), adequate (100%) and high (200%) levels of dietary zinc. The calcium, magnesium, sodium and potassium contents in serum and organs were measured by ICP. There were no significant differences in the food intake, weight gain and feed efficiency ratio among the different dietary zinc levels. Also, the liver, kidney and spleen weight did not show the significant differences among each level of dietary zinc. However, serum sodium and potassium concentrations in the low zinc diet group were significantly higher than in the other diet groups. In high zinc diet group, the calcium contents of liver was significantly higher than in the other diet groups, magnesium and potassium contents of liver were higher than in the low zinc diet group. The sodium contents of liver and magnesium and potassium contents of spleen were significantly lower in the low zinc diet group than in the other diet groups. In conclusion, the macro mineral contents of serum, liver and spleen in obese rats were changed by dietary zinc levels. Especially, the low zinc diet group considerably changed of macro mineral contents in organs. Therefore, it may be suggested that adequate level of dietary zinc in obese individuals should be required.

저자의 다른 논문

참고문헌 (26)

  1. Larsson B. 1990. Obesity, fat distribution and cardiovascular disease. In Progress in Obese Research. Oomura Y, ed. John Libbey & Comp. Ltd., London, UK. p 375-379 
  2. Chen MD, Lin PY, Lin WH, Cheng V. 1988. Zinc in hair and serum of obese individuals in Taiwan. Am J Clin Nutr 48: 1307-1309 
  3. Luque-Diaz MJ, Dean-Guelbenzu M, Culebras-Poza JM. 1982. Changes in the metabolism of iron, copper and zinc in obesity. Rev Esp Fisiol 38S: 155-158 
  4. Luque-Diaz MJ, Dean-Guelbenzu M, Culebras-Poza JM. 1982. Changes in the metabolism of iron, copper and zinc in obesity. Rev Esp Fisiol 38S: 155-158 
  5. Foldes J, Shih MS, Levy J. 1992. Bone structure and calcium metabolism in obese Zucker rats. Int J Obese Relat Metab Disorb 16: 95-102 
  6. Chandra RK, Kutty KM. 1997. Immuocompetence in obesity. Acta Paediatr Scand 69: 25-30 
  7. Yakinci C, Pac A, Kucukaby FZ, Tayfun M, Gul A. 1997. Serum zinc, copper and magnesium levels in obese children. Acta Paediatr Jpn 39: 339-441 
  8. Taneja SK, Mahajan M, Arye P. 1996. Excess bioavailability of zinc may cause obesity in humans. Experientia 52: 31-33 
  9. Failla ML, Kennedy ML, Chen ML. 1988. Iron metabolism in genetically obese (ob/ob) mice. J Nutr 118: 46-51 
  10. O'Dell BL. 1989. Mineral interactions relevant to nutrient requirement. J Nutr 119: 1832-1838 
  11. Sherman AR, Tissue NT. 1981. Tissue iron, copper and zinc levels in offspring of iron-sufficient and iron-deficient rats. J Nutr 111: 266-275 
  12. Sherman AR, Guthrie HA, Woklinsky I. 1977. Interrelationships between dietary iron and tissue zinc and copper levels and serum lipids in rats. Proc Soc Exp Biol Med 156: 396-401 
  13. Jun YS. 1998. Effect of iron intakes on macromineral utilization in rats. J Korean Soc Food Sci Nutr 27: 1273-1278 
  14. Jun YS, Choi MK, Kim AJ, Kim MH, Sung CJ. 2002. Effect of iron supplementation on mineral utilization in rats. J Korean Soc Food Sci Nutr 31: 1658-1663 
  15. Choi MK, Jun YS. 1999. Effect of copper supplementation on mineral utilization in rats. J Korean Soc Food Sci Nutr 28: 1124-1130 
  16. Fisher PW, Giroux A, L'Abbe MR. 1981. The effect of diet ary zinc on intestinal copper absorption. Am J Clin Nutr 34: 1670-1675 
  17. Begin-Heick N, Dalpe-Scott M, Rowe J, Heick HM. 1985. Zinc supplementation attenuates insulin secretory activity in pancreatic islets of the ob/ob mouse. Diabetes 34: 179-184 
  18. Boquist L, Lernmak A. 1989. Effect of the endocrine pancreas in Chinese hamsters fed zinc deficient diet. Acta Path Microbiol Scand 76: 215-228 
  19. Kang HK, Harvey PW, Valentine JL, Swendseid ME. 1977. Zinc, iron, copper and magnesium concentrations in tissues of rats fed various amounts of zinc. Clin Chem 23: 1834-1837 
  20. Song MK. 1987. Influence of dietary zinc on sodium and potassium metabolism in the rat. Miner Electrolyte Metab 13: 178-182 
  21. Prasad AS. 1993. Biochemistry of zinc. Plenum Publishing, New York, USA. p 193-218 
  22. Lind L, Lithell H, Hvarfner A, Pollar T, Ljunghall S. 1993. On the relationships between mineral metabolism, obesity and fat distribution. Eur J Clin Invest 23: 307-310 
  23. Kenney ML, Failla ML, Smith JC. 1987. Influence of genetic obesity in tissue concentrations of zinc, copper, manganese and iron in mice. J Nutr 116: 1432-1441 
  24. Wallwork JC, Fosmire GJ, Sandstead HH. 1981. Effect of zinc deficiency on appetite and plasma amino acid concentrations in the rat. Br J Nutr 45: 127-136 
  25. Seaborn CD, Stoecker BJ. 1989. Effect of starch, sucrose, fructose and glucose on chromium absorption and tissue concentrations in obese and lean mice. J Nutr 119: 1444-1451 
  26. Gupta RP, Verma PC, Sadana JR, Gupta VK. 1989. Effect of experimental zinc deficiency and repletion on sodium, potassium, copper and iron concentrations in guinea-pigs. Br J Nutr 62: 407-414 

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

DOI 인용 스타일